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Q90629 (TRY3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subcellular location

Secretedextracellular space.

Tissue specificity

High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 peptidase S1 domain.

Ontologies

Keywords
   Biological processDigestion
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   Molecular functionHydrolase
Protease
Serine protease
   PTMDisulfide bond
Zymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdigestion

Inferred from electronic annotation. Source: UniProtKB-KW

proteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 By similarity
Propeptide17 – 259Activation peptide By similarity
PRO_0000028223
Chain26 – 248223Trypsin II-P29
PRO_0000028224

Regions

Domain26 – 246221Peptidase S1

Sites

Active site651Charge relay system By similarity
Active site1091Charge relay system By similarity
Active site2021Charge relay system By similarity
Metal binding771Calcium By similarity
Metal binding791Calcium; via carbonyl oxygen By similarity
Metal binding821Calcium; via carbonyl oxygen By similarity
Metal binding871Calcium By similarity
Site1961Required for specificity By similarity

Amino acid modifications

Disulfide bond32 ↔ 162 By similarity
Disulfide bond50 ↔ 66 By similarity
Disulfide bond134 ↔ 235 By similarity
Disulfide bond141 ↔ 208 By similarity
Disulfide bond173 ↔ 187 By similarity
Disulfide bond198 ↔ 222 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90629 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: E5E16B07622B588E

FASTA24826,622
        10         20         30         40         50         60 
MKFLFLILSC LGAAVAFPGG ADDDKIVGGY TCPEHSVPYQ VSLNSGYHFC GGSLINSQWV 

        70         80         90        100        110        120 
LSAAHCYKSR IQVRLGEYNI DVQEDSEVVR SSSVIIRHPK YSSITLNNDI MLIKLASAVE 

       130        140        150        160        170        180 
YSADIQPIAL PSSCAKAGTE CLISGWGNTL SNGYNYPELL QCLNAPILSD QECQEAYPGD 

       190        200        210        220        230        240 
ITSNMICVGF LEGGKDSCQG DSGGPVVCNG ELQGIVSWGI GCALKGYPGV YTKVCNYVDW 


IQETIAAY 

« Hide

References

[1]"Isolation and characterization of the chicken trypsinogen gene family."
Wang K., Gan L., Lee I., Hood L.E.
Biochem. J. 307:471-479(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15157 mRNA. Translation: AAA79914.1.
PIRS55066.
RefSeqNP_990715.1. NM_205384.1.
UniGeneGga.10164.

3D structure databases

ProteinModelPortalQ90629.
SMRQ90629. Positions 26-247.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ90629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396344.
KEGGgga:396344.

Organism-specific databases

CTD5645.

Phylogenomic databases

eggNOGCOG5640.
HOGENOMHOG000251820.
HOVERGENHBG013304.
InParanoidQ90629.
KOK01312.

Family and domain databases

InterProIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
PROSITEPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816392.
PROQ90629.

Entry information

Entry nameTRY3_CHICK
AccessionPrimary (citable) accession number: Q90629
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 22, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries