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Protein

Trypsin II-P29

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Metal bindingi77CalciumBy similarity1
Metal bindingi79Calcium; via carbonyl oxygenBy similarity1
Metal bindingi82Calcium; via carbonyl oxygenBy similarity1
Metal bindingi87CalciumBy similarity1
Active sitei109Charge relay systemBy similarity1
Sitei196Required for specificityBy similarity1
Active sitei202Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin II-P29 (EC:3.4.21.4)
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16By similarityAdd BLAST16
PropeptideiPRO_000002822317 – 25Activation peptideBy similarity9
ChainiPRO_000002822426 – 248Trypsin II-P29Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 162PROSITE-ProRule annotation
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi134 ↔ 235PROSITE-ProRule annotation
Disulfide bondi141 ↔ 208PROSITE-ProRule annotation
Disulfide bondi173 ↔ 187PROSITE-ProRule annotation
Disulfide bondi198 ↔ 222PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ90629.
PRIDEiQ90629.

Expressioni

Tissue specificityi

High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029849.

Structurei

3D structure databases

ProteinModelPortaliQ90629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST221

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
KOiK01312.
OrthoDBiEOG091G0DF7.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90629-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFLFLILSC LGAAVAFPGG ADDDKIVGGY TCPEHSVPYQ VSLNSGYHFC
60 70 80 90 100
GGSLINSQWV LSAAHCYKSR IQVRLGEYNI DVQEDSEVVR SSSVIIRHPK
110 120 130 140 150
YSSITLNNDI MLIKLASAVE YSADIQPIAL PSSCAKAGTE CLISGWGNTL
160 170 180 190 200
SNGYNYPELL QCLNAPILSD QECQEAYPGD ITSNMICVGF LEGGKDSCQG
210 220 230 240
DSGGPVVCNG ELQGIVSWGI GCALKGYPGV YTKVCNYVDW IQETIAAY
Length:248
Mass (Da):26,622
Last modified:November 1, 1996 - v1
Checksum:iE5E16B07622B588E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15157 mRNA. Translation: AAA79914.1.
PIRiS55066.
RefSeqiNP_990715.1. NM_205384.1.
UniGeneiGga.10164.

Genome annotation databases

GeneIDi396344.
KEGGigga:396344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15157 mRNA. Translation: AAA79914.1.
PIRiS55066.
RefSeqiNP_990715.1. NM_205384.1.
UniGeneiGga.10164.

3D structure databases

ProteinModelPortaliQ90629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000029849.

Proteomic databases

PaxDbiQ90629.
PRIDEiQ90629.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396344.
KEGGigga:396344.

Organism-specific databases

CTDi5645.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
KOiK01312.
OrthoDBiEOG091G0DF7.

Miscellaneous databases

PROiQ90629.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRY3_CHICK
AccessioniPrimary (citable) accession number: Q90629
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.