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Q90629

- TRY3_CHICK

UniProt

Q90629 - TRY3_CHICK

Protein

Trypsin II-P29

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Metal bindingi77 – 771CalciumBy similarity
    Metal bindingi79 – 791Calcium; via carbonyl oxygenBy similarity
    Metal bindingi82 – 821Calcium; via carbonyl oxygenBy similarity
    Metal bindingi87 – 871CalciumBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Sitei196 – 1961Required for specificityBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_197231. Activation of Matrix Metalloproteinases.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin II-P29 (EC:3.4.21.4)
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616By similarityAdd
    BLAST
    Propeptidei17 – 259Activation peptideBy similarityPRO_0000028223
    Chaini26 – 248223Trypsin II-P29PRO_0000028224Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 162PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi134 ↔ 235PROSITE-ProRule annotation
    Disulfide bondi141 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi173 ↔ 187PROSITE-ProRule annotation
    Disulfide bondi198 ↔ 222PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiQ90629.

    Expressioni

    Tissue specificityi

    High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90629.
    SMRiQ90629. Positions 26-247.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 246221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ90629.
    KOiK01312.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90629-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLFLILSC LGAAVAFPGG ADDDKIVGGY TCPEHSVPYQ VSLNSGYHFC    50
    GGSLINSQWV LSAAHCYKSR IQVRLGEYNI DVQEDSEVVR SSSVIIRHPK 100
    YSSITLNNDI MLIKLASAVE YSADIQPIAL PSSCAKAGTE CLISGWGNTL 150
    SNGYNYPELL QCLNAPILSD QECQEAYPGD ITSNMICVGF LEGGKDSCQG 200
    DSGGPVVCNG ELQGIVSWGI GCALKGYPGV YTKVCNYVDW IQETIAAY 248
    Length:248
    Mass (Da):26,622
    Last modified:November 1, 1996 - v1
    Checksum:iE5E16B07622B588E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15157 mRNA. Translation: AAA79914.1.
    PIRiS55066.
    RefSeqiNP_990715.1. NM_205384.1.
    UniGeneiGga.10164.

    Genome annotation databases

    GeneIDi396344.
    KEGGigga:396344.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15157 mRNA. Translation: AAA79914.1 .
    PIRi S55066.
    RefSeqi NP_990715.1. NM_205384.1.
    UniGenei Gga.10164.

    3D structure databases

    ProteinModelPortali Q90629.
    SMRi Q90629. Positions 26-247.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q90629.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396344.
    KEGGi gga:396344.

    Organism-specific databases

    CTDi 5645.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q90629.
    KOi K01312.

    Enzyme and pathway databases

    Reactomei REACT_197231. Activation of Matrix Metalloproteinases.

    Miscellaneous databases

    NextBioi 20816392.
    PROi Q90629.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the chicken trypsinogen gene family."
      Wang K., Gan L., Lee I., Hood L.E.
      Biochem. J. 307:471-479(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTRY3_CHICK
    AccessioniPrimary (citable) accession number: Q90629
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3