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Q90627

- TRY1_CHICK

UniProt

Q90627 - TRY1_CHICK

Protein

Trypsin I-P1

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

    Cofactori

    Binds 1 calcium ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Charge relay systemBy similarity
    Metal bindingi77 – 771CalciumBy similarity
    Metal bindingi79 – 791Calcium; via carbonyl oxygenBy similarity
    Metal bindingi87 – 871CalciumBy similarity
    Active sitei109 – 1091Charge relay systemBy similarity
    Sitei196 – 1961Required for specificityBy similarity
    Active sitei202 – 2021Charge relay systemBy similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. serine-type endopeptidase activity Source: InterPro

    GO - Biological processi

    1. digestion Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Digestion

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trypsin I-P1 (EC:3.4.21.4)
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515By similarityAdd
    BLAST
    Propeptidei16 – 2510Activation peptideBy similarityPRO_0000028219
    Chaini26 – 248223Trypsin I-P1PRO_0000028220Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi32 ↔ 162PROSITE-ProRule annotation
    Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
    Disulfide bondi134 ↔ 235PROSITE-ProRule annotation
    Disulfide bondi141 ↔ 208PROSITE-ProRule annotation
    Disulfide bondi173 ↔ 187PROSITE-ProRule annotation
    Disulfide bondi198 ↔ 222PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Zymogen

    Proteomic databases

    PaxDbiQ90627.

    Expressioni

    Tissue specificityi

    High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000016613.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90627.
    SMRiQ90627. Positions 26-248.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 246221Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ90627.
    KOiK01312.
    PhylomeDBiQ90627.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90627-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLVLVAFV GVTVAFPISD EDDDKIVGGY SCARSAAPYQ VSLNSGYHFC    50
    GGSLISSQWV LSAAHCYKSS IQVKLGEYNL AAQDGSEQTI SSSKVIRHSG 100
    YNANTLNNDI MLIKLSKAAT LNSYVNTVPL PTSCVTAGTT CLISGWGNTL 150
    SSGSLYPDVL QCLNAPVLSS SQCSSAYPGR ITSNMICIGY LNGGKDSCQG 200
    DSGGPVVCNG QLQGIVSWGI GCAQKGYPGV YTKVCNYVSW IKTTMSSN 248
    Length:248
    Mass (Da):26,070
    Last modified:November 1, 1996 - v1
    Checksum:iC4CF589912B23D98
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15155 mRNA. Translation: AAA79912.1.
    PIRiS55067.
    RefSeqiNP_990716.1. NM_205385.1.
    UniGeneiGga.4442.
    Gga.51254.

    Genome annotation databases

    GeneIDi396345.
    KEGGigga:396345.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15155 mRNA. Translation: AAA79912.1 .
    PIRi S55067.
    RefSeqi NP_990716.1. NM_205385.1.
    UniGenei Gga.4442.
    Gga.51254.

    3D structure databases

    ProteinModelPortali Q90627.
    SMRi Q90627. Positions 26-248.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000016613.

    Proteomic databases

    PaxDbi Q90627.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396345.
    KEGGi gga:396345.

    Organism-specific databases

    CTDi 5646.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q90627.
    KOi K01312.
    PhylomeDBi Q90627.

    Miscellaneous databases

    NextBioi 20816393.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the chicken trypsinogen gene family."
      Wang K., Gan L., Lee I., Hood L.E.
      Biochem. J. 307:471-479(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.

    Entry informationi

    Entry nameiTRY1_CHICK
    AccessioniPrimary (citable) accession number: Q90627
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3