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Q90627

- TRY1_CHICK

UniProt

Q90627 - TRY1_CHICK

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Protein
Trypsin I-P1
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Charge relay system By similarity
Metal bindingi77 – 771Calcium By similarity
Metal bindingi79 – 791Calcium; via carbonyl oxygen By similarity
Metal bindingi87 – 871Calcium By similarity
Active sitei109 – 1091Charge relay system By similarity
Sitei196 – 1961Required for specificity By similarity
Active sitei202 – 2021Charge relay system By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro

GO - Biological processi

  1. digestion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Digestion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Trypsin I-P1 (EC:3.4.21.4)
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 By similarity
Add
BLAST
Propeptidei16 – 2510Activation peptide By similarity
PRO_0000028219
Chaini26 – 248223Trypsin I-P1
PRO_0000028220Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 162 By similarity
Disulfide bondi50 ↔ 66 By similarity
Disulfide bondi134 ↔ 235 By similarity
Disulfide bondi141 ↔ 208 By similarity
Disulfide bondi173 ↔ 187 By similarity
Disulfide bondi198 ↔ 222 By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

PaxDbiQ90627.

Expressioni

Tissue specificityi

High levels are seen in the pancreas while lower levels are found in the liver, spleen and thymus.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016613.

Structurei

3D structure databases

ProteinModelPortaliQ90627.
SMRiQ90627. Positions 26-248.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 246221Peptidase S1
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ90627.
KOiK01312.
PhylomeDBiQ90627.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90627-1 [UniParc]FASTAAdd to Basket

« Hide

MKFLVLVAFV GVTVAFPISD EDDDKIVGGY SCARSAAPYQ VSLNSGYHFC    50
GGSLISSQWV LSAAHCYKSS IQVKLGEYNL AAQDGSEQTI SSSKVIRHSG 100
YNANTLNNDI MLIKLSKAAT LNSYVNTVPL PTSCVTAGTT CLISGWGNTL 150
SSGSLYPDVL QCLNAPVLSS SQCSSAYPGR ITSNMICIGY LNGGKDSCQG 200
DSGGPVVCNG QLQGIVSWGI GCAQKGYPGV YTKVCNYVSW IKTTMSSN 248
Length:248
Mass (Da):26,070
Last modified:November 1, 1996 - v1
Checksum:iC4CF589912B23D98
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15155 mRNA. Translation: AAA79912.1.
PIRiS55067.
RefSeqiNP_990716.1. NM_205385.1.
UniGeneiGga.4442.
Gga.51254.

Genome annotation databases

GeneIDi396345.
KEGGigga:396345.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U15155 mRNA. Translation: AAA79912.1 .
PIRi S55067.
RefSeqi NP_990716.1. NM_205385.1.
UniGenei Gga.4442.
Gga.51254.

3D structure databases

ProteinModelPortali Q90627.
SMRi Q90627. Positions 26-248.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000016613.

Proteomic databases

PaxDbi Q90627.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396345.
KEGGi gga:396345.

Organism-specific databases

CTDi 5646.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi Q90627.
KOi K01312.
PhylomeDBi Q90627.

Miscellaneous databases

NextBioi 20816393.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the chicken trypsinogen gene family."
    Wang K., Gan L., Lee I., Hood L.E.
    Biochem. J. 307:471-479(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.

Entry informationi

Entry nameiTRY1_CHICK
AccessioniPrimary (citable) accession number: Q90627
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi