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Q90617

- LAMP2_CHICK

UniProt

Q90617 - LAMP2_CHICK

Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction By similarity.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 2
    Short name:
    LAMP-2
    Short name:
    Lysosome-associated membrane protein 2
    Gene namesi
    Name:LAMP2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 4

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation. Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation
    Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. late endosome membrane Source: Ensembl
    3. lysosomal membrane Source: UniProtKB-SubCell
    4. phagocytic vesicle membrane Source: Ensembl
    5. plasma membrane Source: UniProtKB-SubCell
    6. platelet dense granule membrane Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Endosome, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 425398Lysosome-associated membrane glycoprotein 2PRO_0000017114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi37 – 371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi40 ↔ 78PROSITE-ProRule annotation
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi105 – 1051N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
    Glycosylationi163 – 1631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi331 – 3311N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi345 ↔ 382PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ90617.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000013946.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 389362LumenalSequence AnalysisAdd
    BLAST
    Topological domaini415 – 42511CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei390 – 41425HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni28 – 192165First lumenal domainAdd
    BLAST
    Regioni193 – 23846HingeAdd
    BLAST
    Regioni239 – 390152Second lumenal domainAdd
    BLAST

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301998.
    GeneTreeiENSGT00530000063068.
    HOGENOMiHOG000230942.
    HOVERGENiHBG052303.
    InParanoidiQ90617.
    KOiK06528.
    OMAiAEECFAD.
    OrthoDBiEOG7ZD1VH.
    PhylomeDBiQ90617.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS00310. LAMP_1. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform LAMP-2B (identifier: Q90617-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPPRCPAGL ALLLLLLGAC GFFQSYAVEV DVKDASNFTC LYAQWMMKFL    50
    IKYETNSSDY KNASLDLTST VTHNGSICGS DTQAALLAVQ FGDGHSWSIN 100
    FTKNNETYRA EFITFTYNTN DTAVFPDARR QGPVTIVVKD AMHPIQLNNV 150
    FVCHHTTSLE AENVTQIFWN VTMQPFVQNG TISKKESRCY ADTPTAAPTV 200
    LPTVANVTTA STTISPAPTT APKPAENPVT GNYSLKTGNK TCLLATVGLQ 250
    LNISQDKPLL INIDPKTTHA DGTCGNTSAT LKLNDGNRTL IDFTFIVNAS 300
    ASVQKFYLRE VNVTLLNYQN GSVILSADNN NLSKWDASLG NSYMCRKEQT 350
    LEINENLQVH TFNLWVQPFL VKENKFSIAE ECFADSDLNF LIPVAVGMAL 400
    GFLIILVFIS YIIGRRKSRT GYQSV 425
    Length:425
    Mass (Da):46,715
    Last modified:November 1, 1996 - v1
    Checksum:iAC16730A98FDB359
    GO
    Isoform LAMP-2A (identifier: Q90617-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         381-425: ECFADSDLNF...RKSRTGYQSV → DCSPEVDYFI...KHHNTGYEQF

    Show »
    Length:425
    Mass (Da):46,641
    Checksum:i666DC3134A46F18E
    GO
    Isoform LAMP-2C (identifier: Q90617-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         380-425: EECFADSDLN...RKSRTGYQSV → QECSLDDDTI...RKSYAGYQTL

    Show »
    Length:424
    Mass (Da):46,411
    Checksum:i94CA9409BF78F11C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti261 – 2611I → L in AAA99539. (PubMed:7546292)Curated
    Sequence conflicti261 – 2611I → L in AAA99541. (PubMed:7546292)Curated
    Sequence conflicti277 – 2771T → A in AAA99539. (PubMed:7546292)Curated
    Sequence conflicti277 – 2771T → A in AAA99541. (PubMed:7546292)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei380 – 42546EECFA…GYQSV → QECSLDDDTILIPIVVGAAL AGLIVIIVIAYIIGRRKSYA GYQTL in isoform LAMP-2C. 1 PublicationVSP_003047Add
    BLAST
    Alternative sequencei381 – 42545ECFAD…GYQSV → DCSPEVDYFIVPIAVGAALG GLVVLVIMAYFLGHKKHHNT GYEQF in isoform LAMP-2A. 1 PublicationVSP_003048Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10547 mRNA. Translation: AAA99540.1.
    U10546 mRNA. Translation: AAA99539.1.
    U10548 mRNA. Translation: AAA99541.1.
    RefSeqiNP_001001749.1. NM_001001749.1. [Q90617-1]
    UniGeneiGga.2942.

    Genome annotation databases

    EnsembliENSGALT00000013962; ENSGALP00000013946; ENSGALG00000008572. [Q90617-1]
    GeneIDi414800.
    KEGGigga:414800.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10547 mRNA. Translation: AAA99540.1 .
    U10546 mRNA. Translation: AAA99539.1 .
    U10548 mRNA. Translation: AAA99541.1 .
    RefSeqi NP_001001749.1. NM_001001749.1. [Q90617-1 ]
    UniGenei Gga.2942.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000013946.

    Proteomic databases

    PaxDbi Q90617.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000013962 ; ENSGALP00000013946 ; ENSGALG00000008572 . [Q90617-1 ]
    GeneIDi 414800.
    KEGGi gga:414800.

    Organism-specific databases

    CTDi 3920.

    Phylogenomic databases

    eggNOGi NOG301998.
    GeneTreei ENSGT00530000063068.
    HOGENOMi HOG000230942.
    HOVERGENi HBG052303.
    InParanoidi Q90617.
    KOi K06528.
    OMAi AEECFAD.
    OrthoDBi EOG7ZD1VH.
    PhylomeDBi Q90617.
    TreeFami TF316339.

    Miscellaneous databases

    NextBioi 20818724.
    PROi Q90617.

    Family and domain databases

    InterProi IPR018134. LAMP_CS.
    IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS00310. LAMP_1. 1 hit.
    PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c."
      Gough N.R., Hatem C.L., Fambrough D.M.
      DNA Cell Biol. 14:863-867(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LAMP-2A; LAMP-2B AND LAMP-2C).
      Strain: White leghorn.
      Tissue: Brain.

    Entry informationi

    Entry nameiLAMP2_CHICK
    AccessioniPrimary (citable) accession number: Q90617
    Secondary accession number(s): Q90616, Q90618
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3