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Q90617 (LAMP2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 2

Short name=LAMP-2
Short name=Lysosome-associated membrane protein 2
Gene names
Name:LAMP2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity. Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane By similarity.

Sequence similarities

Belongs to the LAMP family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform LAMP-2B (identifier: Q90617-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform LAMP-2A (identifier: Q90617-2)

The sequence of this isoform differs from the canonical sequence as follows:
     381-425: ECFADSDLNF...RKSRTGYQSV → DCSPEVDYFI...KHHNTGYEQF
Isoform LAMP-2C (identifier: Q90617-3)

The sequence of this isoform differs from the canonical sequence as follows:
     380-425: EECFADSDLN...RKSRTGYQSV → QECSLDDDTI...RKSYAGYQTL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 425398Lysosome-associated membrane glycoprotein 2
PRO_0000017114

Regions

Topological domain28 – 389362Lumenal Potential
Transmembrane390 – 41425Helical; Potential
Topological domain415 – 42511Cytoplasmic Potential
Region28 – 192165First lumenal domain
Region193 – 23846Hinge
Region239 – 390152Second lumenal domain

Amino acid modifications

Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation621N-linked (GlcNAc...) Potential
Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation1001N-linked (GlcNAc...) Potential
Glycosylation1051N-linked (GlcNAc...) Potential
Glycosylation1201N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation1701N-linked (GlcNAc...) Potential
Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation2321N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2521N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Glycosylation2981N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential
Glycosylation3311N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 78 By similarity
Disulfide bond153 ↔ 189 By similarity
Disulfide bond242 ↔ 274 By similarity
Disulfide bond345 ↔ 382 By similarity

Natural variations

Alternative sequence380 – 42546EECFA…GYQSV → QECSLDDDTILIPIVVGAAL AGLIVIIVIAYIIGRRKSYA GYQTL in isoform LAMP-2C.
VSP_003047
Alternative sequence381 – 42545ECFAD…GYQSV → DCSPEVDYFIVPIAVGAALG GLVVLVIMAYFLGHKKHHNT GYEQF in isoform LAMP-2A.
VSP_003048

Experimental info

Sequence conflict2611I → L in AAA99539. Ref.1
Sequence conflict2611I → L in AAA99541. Ref.1
Sequence conflict2771T → A in AAA99539. Ref.1
Sequence conflict2771T → A in AAA99541. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform LAMP-2B [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AC16730A98FDB359

FASTA42546,715
        10         20         30         40         50         60 
MAPPRCPAGL ALLLLLLGAC GFFQSYAVEV DVKDASNFTC LYAQWMMKFL IKYETNSSDY 

        70         80         90        100        110        120 
KNASLDLTST VTHNGSICGS DTQAALLAVQ FGDGHSWSIN FTKNNETYRA EFITFTYNTN 

       130        140        150        160        170        180 
DTAVFPDARR QGPVTIVVKD AMHPIQLNNV FVCHHTTSLE AENVTQIFWN VTMQPFVQNG 

       190        200        210        220        230        240 
TISKKESRCY ADTPTAAPTV LPTVANVTTA STTISPAPTT APKPAENPVT GNYSLKTGNK 

       250        260        270        280        290        300 
TCLLATVGLQ LNISQDKPLL INIDPKTTHA DGTCGNTSAT LKLNDGNRTL IDFTFIVNAS 

       310        320        330        340        350        360 
ASVQKFYLRE VNVTLLNYQN GSVILSADNN NLSKWDASLG NSYMCRKEQT LEINENLQVH 

       370        380        390        400        410        420 
TFNLWVQPFL VKENKFSIAE ECFADSDLNF LIPVAVGMAL GFLIILVFIS YIIGRRKSRT 


GYQSV 

« Hide

Isoform LAMP-2A [UniParc].

Checksum: 666DC3134A46F18E
Show »

FASTA42546,641
Isoform LAMP-2C [UniParc].

Checksum: 94CA9409BF78F11C
Show »

FASTA42446,411

References

[1]"The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c."
Gough N.R., Hatem C.L., Fambrough D.M.
DNA Cell Biol. 14:863-867(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LAMP-2A; LAMP-2B AND LAMP-2C).
Strain: White leghorn.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U10547 mRNA. Translation: AAA99540.1.
U10546 mRNA. Translation: AAA99539.1.
U10548 mRNA. Translation: AAA99541.1.
RefSeqNP_001001749.1. NM_001001749.1.
UniGeneGga.2942.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000013946.

Proteomic databases

PaxDbQ90617.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000013962; ENSGALP00000013946; ENSGALG00000008572. [Q90617-1]
GeneID414800.
KEGGgga:414800.

Organism-specific databases

CTD3920.

Phylogenomic databases

eggNOGNOG301998.
GeneTreeENSGT00530000063068.
HOGENOMHOG000230942.
HOVERGENHBG052303.
InParanoidQ90617.
KOK06528.
OMAAEECFAD.
OrthoDBEOG7ZD1VH.
PhylomeDBQ90617.
TreeFamTF316339.

Family and domain databases

InterProIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20818724.
PROQ90617.

Entry information

Entry nameLAMP2_CHICK
AccessionPrimary (citable) accession number: Q90617
Secondary accession number(s): Q90616, Q90618
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families