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Q90617

- LAMP2_CHICK

UniProt

Q90617 - LAMP2_CHICK

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Protein
Lysosome-associated membrane glycoprotein 2
Gene
LAMP2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Gene namesi
Name:LAMP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 4

Subcellular locationi

Cell membrane; Single-pass type I membrane protein By similarity. Endosome membrane; Single-pass type I membrane protein By similarity. Lysosome membrane; Single-pass type I membrane protein By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 389362Lumenal Reviewed prediction
Add
BLAST
Transmembranei390 – 41425Helical; Reviewed prediction
Add
BLAST
Topological domaini415 – 42511Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. late endosome membrane Source: Ensembl
  3. lysosomal membrane Source: UniProtKB-SubCell
  4. phagocytic vesicle membrane Source: Ensembl
  5. plasma membrane Source: UniProtKB-SubCell
  6. platelet dense granule membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed prediction
Add
BLAST
Chaini28 – 425398Lysosome-associated membrane glycoprotein 2
PRO_0000017114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi40 ↔ 78 By similarity
Glycosylationi56 – 561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi100 – 1001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi105 – 1051N-linked (GlcNAc...) Reviewed prediction
Glycosylationi120 – 1201N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi153 ↔ 189 By similarity
Glycosylationi163 – 1631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi170 – 1701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi179 – 1791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi232 – 2321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi242 ↔ 274 By similarity
Glycosylationi252 – 2521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi276 – 2761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi287 – 2871N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi320 – 3201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi331 – 3311N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi345 ↔ 382 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90617.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013946.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 192165First lumenal domain
Add
BLAST
Regioni193 – 23846Hinge
Add
BLAST
Regioni239 – 390152Second lumenal domain
Add
BLAST

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301998.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ90617.
KOiK06528.
OMAiAEECFAD.
OrthoDBiEOG7ZD1VH.
PhylomeDBiQ90617.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform LAMP-2B (identifier: Q90617-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAPPRCPAGL ALLLLLLGAC GFFQSYAVEV DVKDASNFTC LYAQWMMKFL    50
IKYETNSSDY KNASLDLTST VTHNGSICGS DTQAALLAVQ FGDGHSWSIN 100
FTKNNETYRA EFITFTYNTN DTAVFPDARR QGPVTIVVKD AMHPIQLNNV 150
FVCHHTTSLE AENVTQIFWN VTMQPFVQNG TISKKESRCY ADTPTAAPTV 200
LPTVANVTTA STTISPAPTT APKPAENPVT GNYSLKTGNK TCLLATVGLQ 250
LNISQDKPLL INIDPKTTHA DGTCGNTSAT LKLNDGNRTL IDFTFIVNAS 300
ASVQKFYLRE VNVTLLNYQN GSVILSADNN NLSKWDASLG NSYMCRKEQT 350
LEINENLQVH TFNLWVQPFL VKENKFSIAE ECFADSDLNF LIPVAVGMAL 400
GFLIILVFIS YIIGRRKSRT GYQSV 425
Length:425
Mass (Da):46,715
Last modified:November 1, 1996 - v1
Checksum:iAC16730A98FDB359
GO
Isoform LAMP-2A (identifier: Q90617-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-425: ECFADSDLNF...RKSRTGYQSV → DCSPEVDYFI...KHHNTGYEQF

Show »
Length:425
Mass (Da):46,641
Checksum:i666DC3134A46F18E
GO
Isoform LAMP-2C (identifier: Q90617-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-425: EECFADSDLN...RKSRTGYQSV → QECSLDDDTI...RKSYAGYQTL

Show »
Length:424
Mass (Da):46,411
Checksum:i94CA9409BF78F11C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei380 – 42546EECFA…GYQSV → QECSLDDDTILIPIVVGAAL AGLIVIIVIAYIIGRRKSYA GYQTL in isoform LAMP-2C.
VSP_003047Add
BLAST
Alternative sequencei381 – 42545ECFAD…GYQSV → DCSPEVDYFIVPIAVGAALG GLVVLVIMAYFLGHKKHHNT GYEQF in isoform LAMP-2A.
VSP_003048Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti261 – 2611I → L in AAA99539. 1 Publication
Sequence conflicti261 – 2611I → L in AAA99541. 1 Publication
Sequence conflicti277 – 2771T → A in AAA99539. 1 Publication
Sequence conflicti277 – 2771T → A in AAA99541. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10547 mRNA. Translation: AAA99540.1.
U10546 mRNA. Translation: AAA99539.1.
U10548 mRNA. Translation: AAA99541.1.
RefSeqiNP_001001749.1. NM_001001749.1. [Q90617-1]
UniGeneiGga.2942.

Genome annotation databases

EnsembliENSGALT00000013962; ENSGALP00000013946; ENSGALG00000008572. [Q90617-1]
GeneIDi414800.
KEGGigga:414800.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10547 mRNA. Translation: AAA99540.1 .
U10546 mRNA. Translation: AAA99539.1 .
U10548 mRNA. Translation: AAA99541.1 .
RefSeqi NP_001001749.1. NM_001001749.1. [Q90617-1 ]
UniGenei Gga.2942.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000013946.

Proteomic databases

PaxDbi Q90617.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000013962 ; ENSGALP00000013946 ; ENSGALG00000008572 . [Q90617-1 ]
GeneIDi 414800.
KEGGi gga:414800.

Organism-specific databases

CTDi 3920.

Phylogenomic databases

eggNOGi NOG301998.
GeneTreei ENSGT00530000063068.
HOGENOMi HOG000230942.
HOVERGENi HBG052303.
InParanoidi Q90617.
KOi K06528.
OMAi AEECFAD.
OrthoDBi EOG7ZD1VH.
PhylomeDBi Q90617.
TreeFami TF316339.

Miscellaneous databases

NextBioi 20818724.
PROi Q90617.

Family and domain databases

InterProi IPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c."
    Gough N.R., Hatem C.L., Fambrough D.M.
    DNA Cell Biol. 14:863-867(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LAMP-2A; LAMP-2B AND LAMP-2C).
    Strain: White leghorn.
    Tissue: Brain.

Entry informationi

Entry nameiLAMP2_CHICK
AccessioniPrimary (citable) accession number: Q90617
Secondary accession number(s): Q90616, Q90618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi