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Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Gene namesi
Name:LAMP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

  • Cell membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation
  • Endosome membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation
  • Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation

  • Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 389LumenalSequence analysisAdd BLAST362
Transmembranei390 – 414HelicalPROSITE-ProRule annotationAdd BLAST25
Topological domaini415 – 425CytoplasmicPROSITE-ProRule annotationAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001711428 – 425Lysosome-associated membrane glycoprotein 2Add BLAST398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi40 ↔ 78PROSITE-ProRule annotation
Glycosylationi56N-linked (GlcNAc...)Sequence analysis1
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Glycosylationi105N-linked (GlcNAc...)Sequence analysis1
Glycosylationi120N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
Glycosylationi163N-linked (GlcNAc...)Sequence analysis1
Glycosylationi170N-linked (GlcNAc...)Sequence analysis1
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi206N-linked (GlcNAc...)Sequence analysis1
Glycosylationi232N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi242 ↔ 274PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1
Glycosylationi331N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi345 ↔ 382PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90617.

Expressioni

Gene expression databases

BgeeiENSGALG00000008572.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013946.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni28 – 192First lumenal domainAdd BLAST165
Regioni193 – 238HingeAdd BLAST46
Regioni239 – 390Second lumenal domainAdd BLAST152

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ90617.
KOiK06528.
OMAiAEECFAD.
OrthoDBiEOG091G09EV.
PhylomeDBiQ90617.
TreeFamiTF316339.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform LAMP-2B (identifier: Q90617-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPPRCPAGL ALLLLLLGAC GFFQSYAVEV DVKDASNFTC LYAQWMMKFL
60 70 80 90 100
IKYETNSSDY KNASLDLTST VTHNGSICGS DTQAALLAVQ FGDGHSWSIN
110 120 130 140 150
FTKNNETYRA EFITFTYNTN DTAVFPDARR QGPVTIVVKD AMHPIQLNNV
160 170 180 190 200
FVCHHTTSLE AENVTQIFWN VTMQPFVQNG TISKKESRCY ADTPTAAPTV
210 220 230 240 250
LPTVANVTTA STTISPAPTT APKPAENPVT GNYSLKTGNK TCLLATVGLQ
260 270 280 290 300
LNISQDKPLL INIDPKTTHA DGTCGNTSAT LKLNDGNRTL IDFTFIVNAS
310 320 330 340 350
ASVQKFYLRE VNVTLLNYQN GSVILSADNN NLSKWDASLG NSYMCRKEQT
360 370 380 390 400
LEINENLQVH TFNLWVQPFL VKENKFSIAE ECFADSDLNF LIPVAVGMAL
410 420
GFLIILVFIS YIIGRRKSRT GYQSV
Length:425
Mass (Da):46,715
Last modified:November 1, 1996 - v1
Checksum:iAC16730A98FDB359
GO
Isoform LAMP-2A (identifier: Q90617-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     381-425: ECFADSDLNF...RKSRTGYQSV → DCSPEVDYFI...KHHNTGYEQF

Show »
Length:425
Mass (Da):46,641
Checksum:i666DC3134A46F18E
GO
Isoform LAMP-2C (identifier: Q90617-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-425: EECFADSDLN...RKSRTGYQSV → QECSLDDDTI...RKSYAGYQTL

Show »
Length:424
Mass (Da):46,411
Checksum:i94CA9409BF78F11C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti261I → L in AAA99539 (PubMed:7546292).Curated1
Sequence conflicti261I → L in AAA99541 (PubMed:7546292).Curated1
Sequence conflicti277T → A in AAA99539 (PubMed:7546292).Curated1
Sequence conflicti277T → A in AAA99541 (PubMed:7546292).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_003047380 – 425EECFA…GYQSV → QECSLDDDTILIPIVVGAAL AGLIVIIVIAYIIGRRKSYA GYQTL in isoform LAMP-2C. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_003048381 – 425ECFAD…GYQSV → DCSPEVDYFIVPIAVGAALG GLVVLVIMAYFLGHKKHHNT GYEQF in isoform LAMP-2A. 1 PublicationAdd BLAST45

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10547 mRNA. Translation: AAA99540.1.
U10546 mRNA. Translation: AAA99539.1.
U10548 mRNA. Translation: AAA99541.1.
RefSeqiNP_001001749.1. NM_001001749.1. [Q90617-1]
UniGeneiGga.2942.

Genome annotation databases

EnsembliENSGALT00000013962; ENSGALP00000013946; ENSGALG00000008572. [Q90617-1]
ENSGALT00000067309; ENSGALP00000050708; ENSGALG00000008572. [Q90617-3]
GeneIDi414800.
KEGGigga:414800.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10547 mRNA. Translation: AAA99540.1.
U10546 mRNA. Translation: AAA99539.1.
U10548 mRNA. Translation: AAA99541.1.
RefSeqiNP_001001749.1. NM_001001749.1. [Q90617-1]
UniGeneiGga.2942.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013946.

Proteomic databases

PaxDbiQ90617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013962; ENSGALP00000013946; ENSGALG00000008572. [Q90617-1]
ENSGALT00000067309; ENSGALP00000050708; ENSGALG00000008572. [Q90617-3]
GeneIDi414800.
KEGGigga:414800.

Organism-specific databases

CTDi3920.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000230942.
HOVERGENiHBG052303.
InParanoidiQ90617.
KOiK06528.
OMAiAEECFAD.
OrthoDBiEOG091G09EV.
PhylomeDBiQ90617.
TreeFamiTF316339.

Enzyme and pathway databases

ReactomeiR-GGA-114608. Platelet degranulation.
R-GGA-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ90617.

Gene expression databases

BgeeiENSGALG00000008572.

Family and domain databases

InterProiIPR018134. LAMP_CS.
IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS00310. LAMP_1. 1 hit.
PS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP2_CHICK
AccessioniPrimary (citable) accession number: Q90617
Secondary accession number(s): Q90616, Q90618
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.