Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Semaphorin-3A

Gene

SEMA3A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to neuropilin.

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: AgBase
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

  • fasciculation of motor neuron axon Source: AgBase
  • motor neuron axon guidance Source: AgBase
  • negative chemotaxis Source: GO_Central
  • negative regulation of axon extension involved in axon guidance Source: GO_Central
  • negative regulation of protein localization to cell surface Source: AgBase
  • neural crest cell migration Source: GO_Central
  • neuron projection maintenance Source: AgBase
  • positive regulation of neuron migration Source: GO_Central
  • semaphorin-plexin signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3A
Alternative name(s):
Collapsin-1
Short name:
COLL-1
Gene namesi
Name:SEMA3A
Synonyms:COLL1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • axon Source: GO_Central
  • cell body Source: AgBase
  • extracellular region Source: Reactome
  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 772750Semaphorin-3APRO_0000032306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence analysis
Disulfide bondi103 ↔ 114By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi269 ↔ 381By similarity
Disulfide bondi293 ↔ 341By similarity
Disulfide bondi517 ↔ 535By similarity
Glycosylationi591 – 5911N-linked (GlcNAc...)Sequence analysis
Disulfide bondi650 ↔ 723By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ90607.

Expressioni

Tissue specificityi

Expressed at relatively high levels in brain and muscle, moderate levels in lung, bursa, and heart and virtually absent in liver. Collapsin-1, -2, -3, and -5 bind to overlapping but distinct axon tracts.

Interactioni

GO - Molecular functioni

  • neuropilin binding Source: AgBase
  • semaphorin receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010577.

Structurei

3D structure databases

ProteinModelPortaliQ90607.
SMRiQ90607. Positions 26-520.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 514484SemaPROSITE-ProRule annotationAdd
BLAST
Domaini576 – 66590Ig-like C2-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi728 – 77043Arg/Lys-rich (basic)Add
BLAST

Domaini

Strong binding to neuropilin is mediated by the carboxy third of the protein.

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ90607.
KOiK06840.
PhylomeDBiQ90607.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWLRGIALL SLGVLLAGRV NCQHVKNNVP RLKLSYKEML ESNNIVNFNG
60 70 80 90 100
LANSSSYHTF LLDEERSRLY VGAKDHIFSF NLVNIKEYQK IVWPVSHSRR
110 120 130 140 150
DECKWAGKDI LRECANFIKV LKTYNQTHLY ACGTGAFHPM CTYIEVGSHP
160 170 180 190 200
EDNIFRMEDS HFENGRGKSP YDPKLLTASL LVDGELYSGT AADFMGRDFA
210 220 230 240 250
IFRTLGHHHP IRTEQHDSRW LNDPRFISAH LIPESDNPED DKIYFFFREN
260 270 280 290 300
AIDGEHTGKA THARIGQICK NDFGGHRSLV NKWTTFLKAR LICSVPGPNG
310 320 330 340 350
IDTHFDELQD VFLMNSKDPK NPIVYGVFTT SSNIFKGSAV CMYSMTDVRR
360 370 380 390 400
VFLGPYAHRD GPNYQWVPYQ GRVPYPRPGT CPSKTFGGFD STKDLPDEVI
410 420 430 440 450
TFARSHPAMY NPVFPINSRP IMIKTDVDYQ FTQIVVDRVD AEDGQYDVMF
460 470 480 490 500
IGTDIGTVLK VVSIPKETWH ELEEVLLEEM TVFREPTVIS AMKISTKQQQ
510 520 530 540 550
LYIGSATGVS QLPLHRCDVY GKACAECCLA RDPYCAWDGS SCSRYFPTAK
560 570 580 590 600
RRTRRQDIRN GDPLTHCSDL QHHDNPSGQT LEEKIIYGVE NSSTFLECSP
610 620 630 640 650
KSQRAIVYWQ FQKQNDDHKV EIKVDDRMIR TEQGLLLRSL QRRDSGIYFC
660 670 680 690 700
HAVEHGFIQT LLKVTLEVID TDHLEELLHK EEDADASKTK DATNSMTPSQ
710 720 730 740 750
KIWYRDFMQL INHPNLNTMD EFCEQVWKRD RKQRRQRPAN AQVNTNKWKH
760 770
LQENKKGRNR RTHEFERAPR SV
Length:772
Mass (Da):88,868
Last modified:November 1, 1996 - v1
Checksum:iE91E09DE0CC940AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02528 mRNA. Translation: AAC59638.1.
PIRiA49069.
RefSeqiNP_990308.2. NM_204977.1.
UniGeneiGga.487.

Genome annotation databases

GeneIDi395825.
KEGGigga:395825.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02528 mRNA. Translation: AAC59638.1.
PIRiA49069.
RefSeqiNP_990308.2. NM_204977.1.
UniGeneiGga.487.

3D structure databases

ProteinModelPortaliQ90607.
SMRiQ90607. Positions 26-520.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010577.

Proteomic databases

PaxDbiQ90607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395825.
KEGGigga:395825.

Organism-specific databases

CTDi10371.

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
HOGENOMiHOG000039964.
HOVERGENiHBG055071.
InParanoidiQ90607.
KOiK06840.
PhylomeDBiQ90607.

Miscellaneous databases

PROiQ90607.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
IPR016201. Plexin-like_fold.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones."
    Luo Y., Raible D., Raper J.A.
    Cell 75:217-227(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 322-329; 362-372; 395-403 AND 666-680.
    Tissue: Brain.

Entry informationi

Entry nameiSEM3A_CHICK
AccessioniPrimary (citable) accession number: Q90607
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.