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Protein

Interferon-induced GTP-binding protein Mx

Gene

MX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 128GTPSequence analysis8
Nucleotide bindingi222 – 226GTPSequence analysis5
Nucleotide bindingi291 – 294GTPSequence analysis4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx
Alternative name(s):
Interferon-inducible Mx protein
Gene namesi
Name:MX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066031 – 705Interferon-induced GTP-binding protein MxAdd BLAST705

Proteomic databases

PaxDbiQ90597
PRIDEiQ90597

Expressioni

Inductioni

By interferons.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025952

Structurei

3D structure databases

ProteinModelPortaliQ90597
SMRiQ90597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 384Dynamin-type GPROSITE-ProRule annotationAdd BLAST274
Domaini616 – 705GEDPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 128G1 motifPROSITE-ProRule annotation8
Regioni146 – 148G2 motifPROSITE-ProRule annotation3
Regioni222 – 225G3 motifPROSITE-ProRule annotation4
Regioni291 – 294G4 motifPROSITE-ProRule annotation4
Regioni323 – 326G5 motifPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446 Eukaryota
COG0699 LUCA
HOVERGENiHBG008788
InParanoidiQ90597
KOiK14754
PhylomeDBiQ90597

Family and domain databases

CDDicd08771 DLP_1, 1 hit
InterProiView protein in InterPro
IPR000375 Dynamin_central
IPR001401 Dynamin_GTPase
IPR019762 Dynamin_GTPase_CS
IPR022812 Dynamin_SF
IPR030381 G_DYNAMIN_dom
IPR003130 GED
IPR020850 GED_dom
IPR027417 P-loop_NTPase
PANTHERiPTHR11566 PTHR11566, 1 hit
PfamiView protein in Pfam
PF01031 Dynamin_M, 1 hit
PF00350 Dynamin_N, 1 hit
PF02212 GED, 1 hit
PRINTSiPR00195 DYNAMIN
SMARTiView protein in SMART
SM00053 DYNc, 1 hit
SM00302 GED, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00410 G_DYNAMIN_1, 1 hit
PS51718 G_DYNAMIN_2, 1 hit
PS51388 GED, 1 hit

Sequencei

Sequence statusi: Complete.

Q90597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPWSNFSS AFGCPIQIPK QNSNVPPSLP VPVGVFGVPL RSGCSNQMAF
60 70 80 90 100
CAPELTDRKP EHEQKVSKRL NDREEDKDEA AACSLDNQYD RKIQPCIDLV
110 120 130 140 150
DSLRKLDIGN DLMLPAIAVI GDRNSGKSSV LEALSGVALP RDKGVITRCP
160 170 180 190 200
LELKLKKMTA PQEWKGVIYY RNTEIQLQNA SEVKKAIRKA QDIVAGTNGS
210 220 230 240 250
ISGELISLEI WSPDVPDLTL IDLPGIAREA VGNQPQDNGQ QIKTLLKKYI
260 270 280 290 300
GCKETIIVVV VPCNVDIATT EALKMAQEVD PTGERTLGVL TKPDLVNEGT
310 320 330 340 350
EETVLKIIQN EVIPLRKGYM IVKCYGQMDF CNELSFTSAI QQEREFFETH
360 370 380 390 400
KHFSTLLDEN KATIPHLANK LTDELVGRII KTLPAIEKQV HDALQQAKKE
410 420 430 440 450
LQKYTQSTHP TVSDKTIFLV GLIKAFNEDI SQTMHGKESW FGNEIRLFPK
460 470 480 490 500
IRREFRTWGV KLLESSAKVE EIVCSKLPKY EDQYRGREFP DFISYWTFED
510 520 530 540 550
IIKEQITKLE EPAVAMLNKV IYMVEEKFLQ LANKRFANFQ NLNNAAQARI
560 570 580 590 600
GCISDRQATT AKNCILTQFK MERIIYCQDN IYADDLKAAR AEGISKDTKI
610 620 630 640 650
KDLAFGCASR QCPSFALEMV SHVKAYFTGA SKRLSNQIPL IILSTVLHDF
660 670 680 690 700
GNYLQTSMLH LLQGKEEINY LLQEDHEAAN QQKLLTSRIS HLNKAYQYLV

DFKSL
Length:705
Mass (Da):79,493
Last modified:November 1, 1996 - v1
Checksum:i88378C25B737482B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti5W → R in strain: 16, 17, 25, 7, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti8F → S in strain: Black-bone. 1
Natural varianti21Q → R in strain: 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti41R → P in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti42S → L in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F. 1
Natural varianti72D → N in strain: WL-N. 1
Natural varianti84S → N in strain: WL-N. 1
Natural varianti94Q → R in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti143K → E in strain: WL-F. 1
Natural varianti152E → K in strain: WL-F. 1
Natural varianti158M → V in strain: WL-N. 1
Natural varianti202S → T in strain: 16, 17. 1
Natural varianti308I → V in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti317K → E in strain: WL-F. 1
Natural varianti339A → T in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti352H → R in strain: WL-N. 1
Natural varianti377G → E in strain: Black-bone. 1
Natural varianti505Q → R in strain: Black Minorca and Fayoumi GSP. 1
Natural varianti530Q → R in strain: Black-bone. 1
Natural varianti548A → V in strain: 25, WL-F and WL-N. 1
Natural varianti583A → T in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N. 1
Natural varianti631S → N in strain: 25, Black-bone, WL-F and WL-N. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23168 mRNA Translation: CAA80686.1
AB088533 mRNA Translation: BAC06346.1
AB088534 mRNA Translation: BAC06347.1
AB088535 mRNA Translation: BAC06348.1
AB088536 mRNA Translation: BAC06349.1
AB244818 mRNA Translation: BAF30836.1
DQ788613 Genomic DNA Translation: ABH07788.1
DQ788614 Genomic DNA Translation: ABH07789.1
DQ788615 Genomic DNA Translation: ABH07790.1
DQ788616 Genomic DNA Translation: ABH07791.1
PIRiS34155
RefSeqiNP_989940.1, NM_204609.1
UniGeneiGga.131

Genome annotation databases

GeneIDi395313
KEGGigga:395313

Similar proteinsi

Entry informationi

Entry nameiMX_CHICK
AccessioniPrimary (citable) accession number: Q90597
Secondary accession number(s): Q0KKN7
, Q0PMS3, Q0PMS4, Q0PMS5, Q0PMS6, Q8JFB6, Q8JIF6, Q8JIF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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