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Protein

Interferon-induced GTP-binding protein Mx

Gene

MX

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1288GTPSequence analysis
Nucleotide bindingi222 – 2265GTPSequence analysis
Nucleotide bindingi291 – 2944GTPSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon-induced GTP-binding protein Mx
Alternative name(s):
Interferon-inducible Mx protein
Gene namesi
Name:MX
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Interferon-induced GTP-binding protein MxPRO_0000206603Add
BLAST

Proteomic databases

PaxDbiQ90597.
PRIDEiQ90597.

Expressioni

Inductioni

By interferons.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025952.

Structurei

3D structure databases

ProteinModelPortaliQ90597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini111 – 384274Dynamin-type GAdd
BLAST
Domaini616 – 70590GEDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 GED domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOVERGENiHBG008788.
InParanoidiQ90597.
KOiK14754.
PhylomeDBiQ90597.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPWSNFSS AFGCPIQIPK QNSNVPPSLP VPVGVFGVPL RSGCSNQMAF
60 70 80 90 100
CAPELTDRKP EHEQKVSKRL NDREEDKDEA AACSLDNQYD RKIQPCIDLV
110 120 130 140 150
DSLRKLDIGN DLMLPAIAVI GDRNSGKSSV LEALSGVALP RDKGVITRCP
160 170 180 190 200
LELKLKKMTA PQEWKGVIYY RNTEIQLQNA SEVKKAIRKA QDIVAGTNGS
210 220 230 240 250
ISGELISLEI WSPDVPDLTL IDLPGIAREA VGNQPQDNGQ QIKTLLKKYI
260 270 280 290 300
GCKETIIVVV VPCNVDIATT EALKMAQEVD PTGERTLGVL TKPDLVNEGT
310 320 330 340 350
EETVLKIIQN EVIPLRKGYM IVKCYGQMDF CNELSFTSAI QQEREFFETH
360 370 380 390 400
KHFSTLLDEN KATIPHLANK LTDELVGRII KTLPAIEKQV HDALQQAKKE
410 420 430 440 450
LQKYTQSTHP TVSDKTIFLV GLIKAFNEDI SQTMHGKESW FGNEIRLFPK
460 470 480 490 500
IRREFRTWGV KLLESSAKVE EIVCSKLPKY EDQYRGREFP DFISYWTFED
510 520 530 540 550
IIKEQITKLE EPAVAMLNKV IYMVEEKFLQ LANKRFANFQ NLNNAAQARI
560 570 580 590 600
GCISDRQATT AKNCILTQFK MERIIYCQDN IYADDLKAAR AEGISKDTKI
610 620 630 640 650
KDLAFGCASR QCPSFALEMV SHVKAYFTGA SKRLSNQIPL IILSTVLHDF
660 670 680 690 700
GNYLQTSMLH LLQGKEEINY LLQEDHEAAN QQKLLTSRIS HLNKAYQYLV

DFKSL
Length:705
Mass (Da):79,493
Last modified:November 1, 1996 - v1
Checksum:i88378C25B737482B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51W → R in strain: 16, 17, 25, 7, Black Minorca, Fayoumi GSP, WL-F and WL-N.
Natural varianti8 – 81F → S in strain: Black-bone.
Natural varianti21 – 211Q → R in strain: 25, Black Minorca, Fayoumi GSP and WL-F.
Natural varianti41 – 411R → P in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F.
Natural varianti42 – 421S → L in strain: 16, 17, 25, Black Minorca, Fayoumi GSP and WL-F.
Natural varianti72 – 721D → N in strain: WL-N.
Natural varianti84 – 841S → N in strain: WL-N.
Natural varianti94 – 941Q → R in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
Natural varianti143 – 1431K → E in strain: WL-F.
Natural varianti152 – 1521E → K in strain: WL-F.
Natural varianti158 – 1581M → V in strain: WL-N.
Natural varianti202 – 2021S → T in strain: 16, 17.
Natural varianti308 – 3081I → V in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
Natural varianti317 – 3171K → E in strain: WL-F.
Natural varianti339 – 3391A → T in strain: 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
Natural varianti352 – 3521H → R in strain: WL-N.
Natural varianti377 – 3771G → E in strain: Black-bone.
Natural varianti505 – 5051Q → R in strain: Black Minorca and Fayoumi GSP.
Natural varianti530 – 5301Q → R in strain: Black-bone.
Natural varianti548 – 5481A → V in strain: 25, WL-F and WL-N.
Natural varianti583 – 5831A → T in strain: 16, 17, 25, 7, Black-bone, Black Minorca, Fayoumi GSP, WL-F and WL-N.
Natural varianti631 – 6311S → N in strain: 25, Black-bone, WL-F and WL-N.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23168 mRNA. Translation: CAA80686.1.
AB088533 mRNA. Translation: BAC06346.1.
AB088534 mRNA. Translation: BAC06347.1.
AB088535 mRNA. Translation: BAC06348.1.
AB088536 mRNA. Translation: BAC06349.1.
AB244818 mRNA. Translation: BAF30836.1.
DQ788613 Genomic DNA. Translation: ABH07788.1.
DQ788614 Genomic DNA. Translation: ABH07789.1.
DQ788615 Genomic DNA. Translation: ABH07790.1.
DQ788616 Genomic DNA. Translation: ABH07791.1.
PIRiS34155.
RefSeqiNP_989940.1. NM_204609.1.
UniGeneiGga.131.

Genome annotation databases

GeneIDi395313.
KEGGigga:395313.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23168 mRNA. Translation: CAA80686.1.
AB088533 mRNA. Translation: BAC06346.1.
AB088534 mRNA. Translation: BAC06347.1.
AB088535 mRNA. Translation: BAC06348.1.
AB088536 mRNA. Translation: BAC06349.1.
AB244818 mRNA. Translation: BAF30836.1.
DQ788613 Genomic DNA. Translation: ABH07788.1.
DQ788614 Genomic DNA. Translation: ABH07789.1.
DQ788615 Genomic DNA. Translation: ABH07790.1.
DQ788616 Genomic DNA. Translation: ABH07791.1.
PIRiS34155.
RefSeqiNP_989940.1. NM_204609.1.
UniGeneiGga.131.

3D structure databases

ProteinModelPortaliQ90597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025952.

Proteomic databases

PaxDbiQ90597.
PRIDEiQ90597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395313.
KEGGigga:395313.

Organism-specific databases

CTDi4599.

Phylogenomic databases

eggNOGiKOG0446. Eukaryota.
COG0699. LUCA.
HOVERGENiHBG008788.
InParanoidiQ90597.
KOiK14754.
PhylomeDBiQ90597.

Miscellaneous databases

PROiQ90597.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR000375. Dynamin_central.
IPR001401. Dynamin_GTPase.
IPR019762. Dynamin_GTPase_CS.
IPR022812. Dynamin_SF.
IPR030381. G_DYNAMIN_dom.
IPR003130. GED.
IPR020850. GED_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11566. PTHR11566. 1 hit.
PfamiPF01031. Dynamin_M. 1 hit.
PF00350. Dynamin_N. 1 hit.
PF02212. GED. 1 hit.
[Graphical view]
PRINTSiPR00195. DYNAMIN.
SMARTiSM00053. DYNc. 1 hit.
SM00302. GED. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00410. G_DYNAMIN_1. 1 hit.
PS51718. G_DYNAMIN_2. 1 hit.
PS51388. GED. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMX_CHICK
AccessioniPrimary (citable) accession number: Q90597
Secondary accession number(s): Q0KKN7
, Q0PMS3, Q0PMS4, Q0PMS5, Q0PMS6, Q8JFB6, Q8JIF6, Q8JIF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.