Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor MafK

Gene

MAFK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor MafK
Gene namesi
Name:MAFK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765051 – 156Transcription factor MafKAdd BLAST156

Proteomic databases

PaxDbiQ90596.
PRIDEiQ90596.

Expressioni

Gene expression databases

BgeeiENSGALG00000004189.

Interactioni

Subunit structurei

Homodimer or heterodimer.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006645.

Structurei

3D structure databases

ProteinModelPortaliQ90596.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 114bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 76Basic motifPROSITE-ProRule annotationAdd BLAST26
Regioni79 – 93Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Sequence similaritiesi

Belongs to the bZIP family. Maf subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410ISHX. Eukaryota.
ENOG4111MYK. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ90596.
KOiK09037.
OMAiGPIAPTK.
OrthoDBiEOG091G0H46.
PhylomeDBiQ90596.
TreeFamiTF325689.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTNPKPNKA LKVKEESGEN APVLSDDELV SMSVRELNQH LRGLTKEEVI
60 70 80 90 100
RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM
110 120 130 140 150
KLELDALRSK YEALQTFART VARGPITPTK VATTSVITIV KSAEISSSSV

PFSAAS
Length:156
Mass (Da):17,538
Last modified:November 1, 1997 - v1
Checksum:i4F45BCE40DA41C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16187 mRNA. Translation: BAA03728.1.
PIRiA56253.
RefSeqiNP_990087.1. NM_204756.1.
XP_015149619.1. XM_015294133.1.
XP_015149620.1. XM_015294134.1.
UniGeneiGga.45251.

Genome annotation databases

EnsembliENSGALT00000006656; ENSGALP00000006645; ENSGALG00000004189.
ENSGALT00000054791; ENSGALP00000046925; ENSGALG00000004189.
GeneIDi395518.
KEGGigga:395518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16187 mRNA. Translation: BAA03728.1.
PIRiA56253.
RefSeqiNP_990087.1. NM_204756.1.
XP_015149619.1. XM_015294133.1.
XP_015149620.1. XM_015294134.1.
UniGeneiGga.45251.

3D structure databases

ProteinModelPortaliQ90596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006645.

Proteomic databases

PaxDbiQ90596.
PRIDEiQ90596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000006656; ENSGALP00000006645; ENSGALG00000004189.
ENSGALT00000054791; ENSGALP00000046925; ENSGALG00000004189.
GeneIDi395518.
KEGGigga:395518.

Organism-specific databases

CTDi7975.

Phylogenomic databases

eggNOGiENOG410ISHX. Eukaryota.
ENOG4111MYK. LUCA.
GeneTreeiENSGT00550000074549.
HOGENOMiHOG000045475.
HOVERGENiHBG001725.
InParanoidiQ90596.
KOiK09037.
OMAiGPIAPTK.
OrthoDBiEOG091G0H46.
PhylomeDBiQ90596.
TreeFamiTF325689.

Miscellaneous databases

PROiQ90596.

Gene expression databases

BgeeiENSGALG00000004189.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR008917. TF_DNA-bd.
IPR024874. Transciption_factor_Maf_fam.
[Graphical view]
PANTHERiPTHR10129. PTHR10129. 1 hit.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAFK_CHICK
AccessioniPrimary (citable) accession number: Q90596
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.