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Q90593

- GRP78_CHICK

UniProt

Q90593 - GRP78_CHICK

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Protein
78 kDa glucose-regulated protein
Gene
HSPA5, GRP78
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi34 – 374ATP By similarity
Nucleotide bindingi225 – 2273ATP By similarity
Nucleotide bindingi291 – 2988ATP By similarity
Nucleotide bindingi362 – 3654ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein binding Source: IntAct
  3. ribosome binding Source: Ensembl

GO - Biological processi

  1. ER overload response Source: Ensembl
  2. activation of signaling protein activity involved in unfolded protein response Source: Ensembl
  3. cellular response to glucose starvation Source: Ensembl
  4. cellular response to interleukin-4 Source: Ensembl
  5. cerebellar Purkinje cell layer development Source: Ensembl
  6. cerebellum structural organization Source: Ensembl
  7. negative regulation of apoptotic process Source: Ensembl
  8. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
  9. positive regulation of protein ubiquitination Source: Ensembl
  10. proteolysis involved in cellular protein catabolic process Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_85864. ATF6-alpha activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
78 kDa glucose-regulated protein
Short name:
GRP-78
Alternative name(s):
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein
Short name:
BiP
Gene namesi
Name:HSPA5
Synonyms:GRP78
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 17

Subcellular locationi

GO - Cellular componenti

  1. COP9 signalosome Source: Ensembl
  2. cell surface Source: Ensembl
  3. endoplasmic reticulum chaperone complex Source: Ensembl
  4. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  5. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
  6. integral component of endoplasmic reticulum membrane Source: Ensembl
  7. midbody Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 65263678 kDa glucose-regulated protein
PRO_0000013570Add
BLAST

Proteomic databases

PaxDbiQ90593.
PRIDEiQ90593.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
KCNMA1Q8AYS83EBI-1635886,EBI-1635766

Protein-protein interaction databases

BioGridi676734. 2 interactions.
IntActiQ90593. 1 interaction.
STRINGi9031.ENSGALP00000001474.

Structurei

3D structure databases

ProteinModelPortaliQ90593.
SMRiQ90593. Positions 26-568.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi649 – 6524Prevents secretion from ER By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0443.
GeneTreeiENSGT00750000117237.
HOGENOMiHOG000228135.
HOVERGENiHBG051845.
InParanoidiQ90593.
KOiK09490.
OMAiDKRAVQK.
OrthoDBiEOG780RKX.
PhylomeDBiQ90593.
TreeFamiTF105044.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90593-1 [UniParc]FASTAAdd to Basket

« Hide

MRHLLLALLL LGGARADDEE KKEDVGTVVG IDLGTTYSCV GVFKNGRVEI    50
IANDQGNRIT PSYVAFTPEG ERLIGDAAKN QLTSNPENTV FDAKRLIGRT 100
WNDPSVQQDI KYLPFKVVEK KAKPHIQVDV GGGQTKTFAP EEISAMVLTK 150
MKETAEAYLG KKVTHAVVTV PAYFNDAQRQ ATKDAGTIAG LNVMRIINEP 200
TAAAIAYGLD KREGEKNILV FDLGGGTFDV SLLTIDNGVF EVVATNGDTH 250
LGGEDFDQRV MEHFIKLYKK KTGKDVRKDN RAVQKLRREV EKAKRALSSQ 300
HQARIEIESF FEGEDFSETL TRAKFEELNM DLFRSTMKPV QKVLEDSDLK 350
KSDIDEIVLV GGSTRIPKIQ QLVKEFFNGK EPSRGINPDE AVAYGAAVQA 400
GVLSGDQDTG DLVLLDVCPL TLGIETVGGV MTKLIPRNTV VPTKKSQIFS 450
TASDNQPTVT IKVYEGERPL TKDNHLLGTF DLTGIPPAPR GVPQIEVTFE 500
IDVNGILRVT AEDKGTGNKN KITITNDQNR LTPEEIERMV NDAEKFAEED 550
KKLKERIDAR NELESYAYSL KNQIGDKEKL GGKLSSEDKE TIEKAVEEKI 600
EWLESHQDAD IEDFKSKKKE LEEVVQPIVS KLYGSAGPPP TGEEEAAEKD 650
EL 652
Length:652
Mass (Da):72,019
Last modified:November 1, 1996 - v1
Checksum:i4E4BB58A3EEFAF6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27260 mRNA. Translation: AAA48785.1.
PIRiI50242.
RefSeqiNP_990822.1. NM_205491.1.
UniGeneiGga.4219.

Genome annotation databases

EnsembliENSGALT00000001476; ENSGALP00000001474; ENSGALG00000001000.
GeneIDi396487.
KEGGigga:396487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M27260 mRNA. Translation: AAA48785.1 .
PIRi I50242.
RefSeqi NP_990822.1. NM_205491.1.
UniGenei Gga.4219.

3D structure databases

ProteinModelPortali Q90593.
SMRi Q90593. Positions 26-568.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676734. 2 interactions.
IntActi Q90593. 1 interaction.
STRINGi 9031.ENSGALP00000001474.

Proteomic databases

PaxDbi Q90593.
PRIDEi Q90593.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000001476 ; ENSGALP00000001474 ; ENSGALG00000001000 .
GeneIDi 396487.
KEGGi gga:396487.

Organism-specific databases

CTDi 3309.

Phylogenomic databases

eggNOGi COG0443.
GeneTreei ENSGT00750000117237.
HOGENOMi HOG000228135.
HOVERGENi HBG051845.
InParanoidi Q90593.
KOi K09490.
OMAi DKRAVQK.
OrthoDBi EOG780RKX.
PhylomeDBi Q90593.
TreeFami TF105044.

Enzyme and pathway databases

Reactomei REACT_85864. ATF6-alpha activates chaperone genes.

Miscellaneous databases

NextBioi 20816526.
PROi Q90593.

Family and domain databases

Gene3Di 1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
SUPFAMi SSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation."
    Stoeckle M.Y., Sugano S., Hampe A., Vashishtha A., Pellman D., Hanafusa H.
    Mol. Cell. Biol. 8:2675-2680(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGRP78_CHICK
AccessioniPrimary (citable) accession number: Q90593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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