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Q90593

- GRP78_CHICK

UniProt

Q90593 - GRP78_CHICK

Protein

78 kDa glucose-regulated protein

Gene

HSPA5

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi34 – 374ATPBy similarity
    Nucleotide bindingi225 – 2273ATPBy similarity
    Nucleotide bindingi291 – 2988ATPBy similarity
    Nucleotide bindingi362 – 3654ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. ribosome binding Source: Ensembl

    GO - Biological processi

    1. activation of signaling protein activity involved in unfolded protein response Source: Ensembl
    2. cellular response to glucose starvation Source: Ensembl
    3. cellular response to interleukin-4 Source: Ensembl
    4. cerebellar Purkinje cell layer development Source: Ensembl
    5. cerebellum structural organization Source: Ensembl
    6. ER overload response Source: Ensembl
    7. negative regulation of apoptotic process Source: Ensembl
    8. negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
    9. positive regulation of protein ubiquitination Source: Ensembl
    10. proteolysis involved in cellular protein catabolic process Source: Ensembl

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_85864. ATF6-alpha activates chaperone genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    78 kDa glucose-regulated protein
    Short name:
    GRP-78
    Alternative name(s):
    Heat shock 70 kDa protein 5
    Immunoglobulin heavy chain-binding protein
    Short name:
    BiP
    Gene namesi
    Name:HSPA5
    Synonyms:GRP78
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 17

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. COP9 signalosome Source: Ensembl
    3. endoplasmic reticulum chaperone complex Source: Ensembl
    4. endoplasmic reticulum-Golgi intermediate compartment Source: Ensembl
    5. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    6. integral component of endoplasmic reticulum membrane Source: Ensembl
    7. midbody Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 65263678 kDa glucose-regulated proteinPRO_0000013570Add
    BLAST

    Proteomic databases

    PaxDbiQ90593.
    PRIDEiQ90593.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KCNMA1Q8AYS83EBI-1635886,EBI-1635766

    Protein-protein interaction databases

    BioGridi676734. 2 interactions.
    IntActiQ90593. 1 interaction.
    STRINGi9031.ENSGALP00000001474.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90593.
    SMRiQ90593. Positions 26-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi649 – 6524Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG0443.
    GeneTreeiENSGT00750000117237.
    HOGENOMiHOG000228135.
    HOVERGENiHBG051845.
    InParanoidiQ90593.
    KOiK09490.
    OMAiDKRAVQK.
    OrthoDBiEOG780RKX.
    PhylomeDBiQ90593.
    TreeFamiTF105044.

    Family and domain databases

    Gene3Di1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    SUPFAMiSSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q90593-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRHLLLALLL LGGARADDEE KKEDVGTVVG IDLGTTYSCV GVFKNGRVEI    50
    IANDQGNRIT PSYVAFTPEG ERLIGDAAKN QLTSNPENTV FDAKRLIGRT 100
    WNDPSVQQDI KYLPFKVVEK KAKPHIQVDV GGGQTKTFAP EEISAMVLTK 150
    MKETAEAYLG KKVTHAVVTV PAYFNDAQRQ ATKDAGTIAG LNVMRIINEP 200
    TAAAIAYGLD KREGEKNILV FDLGGGTFDV SLLTIDNGVF EVVATNGDTH 250
    LGGEDFDQRV MEHFIKLYKK KTGKDVRKDN RAVQKLRREV EKAKRALSSQ 300
    HQARIEIESF FEGEDFSETL TRAKFEELNM DLFRSTMKPV QKVLEDSDLK 350
    KSDIDEIVLV GGSTRIPKIQ QLVKEFFNGK EPSRGINPDE AVAYGAAVQA 400
    GVLSGDQDTG DLVLLDVCPL TLGIETVGGV MTKLIPRNTV VPTKKSQIFS 450
    TASDNQPTVT IKVYEGERPL TKDNHLLGTF DLTGIPPAPR GVPQIEVTFE 500
    IDVNGILRVT AEDKGTGNKN KITITNDQNR LTPEEIERMV NDAEKFAEED 550
    KKLKERIDAR NELESYAYSL KNQIGDKEKL GGKLSSEDKE TIEKAVEEKI 600
    EWLESHQDAD IEDFKSKKKE LEEVVQPIVS KLYGSAGPPP TGEEEAAEKD 650
    EL 652
    Length:652
    Mass (Da):72,019
    Last modified:November 1, 1996 - v1
    Checksum:i4E4BB58A3EEFAF6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27260 mRNA. Translation: AAA48785.1.
    PIRiI50242.
    RefSeqiNP_990822.1. NM_205491.1.
    UniGeneiGga.4219.

    Genome annotation databases

    EnsembliENSGALT00000001476; ENSGALP00000001474; ENSGALG00000001000.
    GeneIDi396487.
    KEGGigga:396487.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27260 mRNA. Translation: AAA48785.1 .
    PIRi I50242.
    RefSeqi NP_990822.1. NM_205491.1.
    UniGenei Gga.4219.

    3D structure databases

    ProteinModelPortali Q90593.
    SMRi Q90593. Positions 26-568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676734. 2 interactions.
    IntActi Q90593. 1 interaction.
    STRINGi 9031.ENSGALP00000001474.

    Proteomic databases

    PaxDbi Q90593.
    PRIDEi Q90593.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000001476 ; ENSGALP00000001474 ; ENSGALG00000001000 .
    GeneIDi 396487.
    KEGGi gga:396487.

    Organism-specific databases

    CTDi 3309.

    Phylogenomic databases

    eggNOGi COG0443.
    GeneTreei ENSGT00750000117237.
    HOGENOMi HOG000228135.
    HOVERGENi HBG051845.
    InParanoidi Q90593.
    KOi K09490.
    OMAi DKRAVQK.
    OrthoDBi EOG780RKX.
    PhylomeDBi Q90593.
    TreeFami TF105044.

    Enzyme and pathway databases

    Reactomei REACT_85864. ATF6-alpha activates chaperone genes.

    Miscellaneous databases

    NextBioi 20816526.
    PROi Q90593.

    Family and domain databases

    Gene3Di 1.20.1270.10. 1 hit.
    2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029048. HSP70_C.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    SUPFAMi SSF100920. SSF100920. 1 hit.
    SSF100934. SSF100934. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00297. HSP70_1. 1 hit.
    PS00329. HSP70_2. 1 hit.
    PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "78-kilodalton glucose-regulated protein is induced in Rous sarcoma virus-transformed cells independently of glucose deprivation."
      Stoeckle M.Y., Sugano S., Hampe A., Vashishtha A., Pellman D., Hanafusa H.
      Mol. Cell. Biol. 8:2675-2680(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiGRP78_CHICK
    AccessioniPrimary (citable) accession number: Q90593
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3