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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei361MonosaccharideBy similarity1
Binding sitei432MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT-2, GLUT2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 110ExtracellularSequence analysisAdd BLAST72
Transmembranei111 – 131Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini132 – 136CytoplasmicSequence analysis5
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini185 – 199CytoplasmicSequence analysisAdd BLAST15
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 229ExtracellularSequence analysis9
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 315CytoplasmicSequence analysisAdd BLAST65
Transmembranei316 – 336Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini337 – 350ExtracellularSequence analysisAdd BLAST14
Transmembranei351 – 371Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini372 – 379CytoplasmicSequence analysis8
Transmembranei380 – 400Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini401 – 413ExtracellularSequence analysisAdd BLAST13
Transmembranei414 – 434Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini435 – 445CytoplasmicSequence analysisAdd BLAST11
Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini467 – 471ExtracellularSequence analysis5
Transmembranei472 – 492Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini493 – 533CytoplasmicSequence analysisAdd BLAST41

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503501 – 533Solute carrier family 2, facilitated glucose transporter member 2Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...)Sequence analysis1
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90592.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015129.

Structurei

3D structure databases

ProteinModelPortaliQ90592.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 332Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ90592.
KOiK07593.
PhylomeDBiQ90592.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGKSKMQAE KHLTGTLVLS VFTAVLGFFQ YGYSLGVINA PQKVIEAHYG
60 70 80 90 100
RMLGAIPMVR HATNTSRDNA TITVTIPGTE AWGSSEGTLA PSAGFEDPTV
110 120 130 140 150
SPHILTMYWS LSVSMFAVGG MVSSFTVGWI GDRLGRVKAM LVVNVLSIAG
160 170 180 190 200
NLLMGLAKMG PSHILIIAGR AITGLYCGLS SGLVPMYVSE VSPTALRGAL
210 220 230 240 250
GTLHQLAIVT GILISQVLGL DFLLGNDELW PLLLGLSGVA ALLQFFLLLL
260 270 280 290 300
CPESPRYLYI KLGKVEEAKK SLKRLRGNCD PMKEIAEMEK EKQEAASEKR
310 320 330 340 350
VSIGQLFSSS KYRQAVIVAL MVQISQQFSG INAIFYYSTN IFQRAGVGQP
360 370 380 390 400
VYATIGVGVV NTVFTVISVF LVEKAGRRSL FLAGLMGMLI SAVAMTVGLV
410 420 430 440 450
LLSQFAWMSY VSMVAIFLFV IFFEVGPGPI PWFIVAELFS QGPRPAAIAV
460 470 480 490 500
AGFCNWACNF IVGMCFQYIA DLCGPYVFVV FAVLLLVFFL FAYLKVPETK
510 520 530
GKSFEEIAAA FRRKKLPAKS MTELEDLRGG EEA
Length:533
Mass (Da):57,699
Last modified:November 1, 1996 - v1
Checksum:iD06284CDC2779A3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22932 mRNA. Translation: CAA80519.1.
PIRiS43230.
RefSeqiNP_997061.1. NM_207178.1.
UniGeneiGga.43090.

Genome annotation databases

GeneIDi396272.
KEGGigga:396272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22932 mRNA. Translation: CAA80519.1.
PIRiS43230.
RefSeqiNP_997061.1. NM_207178.1.
UniGeneiGga.43090.

3D structure databases

ProteinModelPortaliQ90592.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015129.

Proteomic databases

PaxDbiQ90592.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396272.
KEGGigga:396272.

Organism-specific databases

CTDi6514.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ90592.
KOiK07593.
PhylomeDBiQ90592.

Enzyme and pathway databases

ReactomeiR-GGA-352832. Glucose transport.

Miscellaneous databases

PROiQ90592.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002440. Glc_transpt_2.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01191. GLUCTRSPORT2.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR2_CHICK
AccessioniPrimary (citable) accession number: Q90592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.