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Protein

Solute carrier family 2, facilitated glucose transporter member 2

Gene

SLC2A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei361MonosaccharideBy similarity1
Binding sitei432MonosaccharideBy similarity1

GO - Molecular functioni

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-352832 Glucose transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 2
Alternative name(s):
Glucose transporter type 2, liver
Short name:
GLUT-2
Gene namesi
Name:SLC2A2
Synonyms:GLUT-2, GLUT2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini39 – 110ExtracellularSequence analysisAdd BLAST72
Transmembranei111 – 131Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini132 – 136CytoplasmicSequence analysis5
Transmembranei137 – 157Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini158 – 163ExtracellularSequence analysis6
Transmembranei164 – 184Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini185 – 199CytoplasmicSequence analysisAdd BLAST15
Transmembranei200 – 220Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini221 – 229ExtracellularSequence analysis9
Transmembranei230 – 250Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini251 – 315CytoplasmicSequence analysisAdd BLAST65
Transmembranei316 – 336Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini337 – 350ExtracellularSequence analysisAdd BLAST14
Transmembranei351 – 371Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini372 – 379CytoplasmicSequence analysis8
Transmembranei380 – 400Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini401 – 413ExtracellularSequence analysisAdd BLAST13
Transmembranei414 – 434Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini435 – 445CytoplasmicSequence analysisAdd BLAST11
Transmembranei446 – 466Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini467 – 471ExtracellularSequence analysis5
Transmembranei472 – 492Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini493 – 533CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503501 – 533Solute carrier family 2, facilitated glucose transporter member 2Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ90592

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015129

Structurei

3D structure databases

ProteinModelPortaliQ90592
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni326 – 332Monosaccharide bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiQ90592
KOiK07593
PhylomeDBiQ90592

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002440 Glc_transpt_2
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01191 GLUCTRSPORT2
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGKSKMQAE KHLTGTLVLS VFTAVLGFFQ YGYSLGVINA PQKVIEAHYG
60 70 80 90 100
RMLGAIPMVR HATNTSRDNA TITVTIPGTE AWGSSEGTLA PSAGFEDPTV
110 120 130 140 150
SPHILTMYWS LSVSMFAVGG MVSSFTVGWI GDRLGRVKAM LVVNVLSIAG
160 170 180 190 200
NLLMGLAKMG PSHILIIAGR AITGLYCGLS SGLVPMYVSE VSPTALRGAL
210 220 230 240 250
GTLHQLAIVT GILISQVLGL DFLLGNDELW PLLLGLSGVA ALLQFFLLLL
260 270 280 290 300
CPESPRYLYI KLGKVEEAKK SLKRLRGNCD PMKEIAEMEK EKQEAASEKR
310 320 330 340 350
VSIGQLFSSS KYRQAVIVAL MVQISQQFSG INAIFYYSTN IFQRAGVGQP
360 370 380 390 400
VYATIGVGVV NTVFTVISVF LVEKAGRRSL FLAGLMGMLI SAVAMTVGLV
410 420 430 440 450
LLSQFAWMSY VSMVAIFLFV IFFEVGPGPI PWFIVAELFS QGPRPAAIAV
460 470 480 490 500
AGFCNWACNF IVGMCFQYIA DLCGPYVFVV FAVLLLVFFL FAYLKVPETK
510 520 530
GKSFEEIAAA FRRKKLPAKS MTELEDLRGG EEA
Length:533
Mass (Da):57,699
Last modified:November 1, 1996 - v1
Checksum:iD06284CDC2779A3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22932 mRNA Translation: CAA80519.1
PIRiS43230
RefSeqiNP_997061.1, NM_207178.1
UniGeneiGga.43090

Genome annotation databases

GeneIDi396272
KEGGigga:396272

Similar proteinsi

Entry informationi

Entry nameiGTR2_CHICK
AccessioniPrimary (citable) accession number: Q90592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health