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Protein

Hemoglobin subunit alpha

Gene

hbaa1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme distal ligand)
Metal bindingi89 – 891Iron (heme proximal ligand)

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • response to hypoxia Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin aa1
Hemoglobin alpha chain
Gene namesi
Name:hbaa1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-980526-79. hbaa1.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 143142Hemoglobin subunit alphaPRO_0000052585Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ90487.
PRIDEiQ90487.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSDARG00000097011.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101541.

Structurei

3D structure databases

ProteinModelPortaliQ90487.
SMRiQ90487. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiQ90487.
OMAiWAKISKS.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSDTDKAV VKAIWAKISP KADEIGAEAL ARMLTVYPQT KTYFSHWADL
60 70 80 90 100
SPGSGPVKKH GKTIMGAVGE AISKIDDLVG GLAALSELHA FKLRVDPANF
110 120 130 140
KILSHNVIVV IAMLFPADFT PEVHVSVDKF FNNLALALSE KYR
Length:143
Mass (Da):15,522
Last modified:January 23, 2007 - v3
Checksum:iEFA41C735DAF161F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50381 Genomic DNA. Translation: AAB05404.1.
U50382 Genomic DNA. Translation: AAB05406.1.
AL929176 Genomic DNA. Translation: CAE48986.1.
UniGeneiDr.150234.
Dr.76023.

Genome annotation databases

EnsembliENSDART00000053078; ENSDARP00000053077; ENSDARG00000097011.
ENSDART00000113098; ENSDARP00000101541; ENSDARG00000097011.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50381 Genomic DNA. Translation: AAB05404.1.
U50382 Genomic DNA. Translation: AAB05406.1.
AL929176 Genomic DNA. Translation: CAE48986.1.
UniGeneiDr.150234.
Dr.76023.

3D structure databases

ProteinModelPortaliQ90487.
SMRiQ90487. Positions 2-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101541.

Proteomic databases

PaxDbiQ90487.
PRIDEiQ90487.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053078; ENSDARP00000053077; ENSDARG00000097011.
ENSDART00000113098; ENSDARP00000101541; ENSDARG00000097011.

Organism-specific databases

ZFINiZDB-GENE-980526-79. hbaa1.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036867.
HOVERGENiHBG009709.
InParanoidiQ90487.
OMAiWAKISKS.
OrthoDBiEOG091G0S0X.
TreeFamiTF332328.

Miscellaneous databases

PROiQ90487.

Gene expression databases

BgeeiENSDARG00000097011.

Family and domain databases

CDDicd08927. Hb-alpha_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002338. Haemoglobin_a-typ.
IPR002339. Haemoglobin_pi.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00612. ALPHAHAEM.
PR00815. PIHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBA_DANRE
AccessioniPrimary (citable) accession number: Q90487
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.