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Protein

Hemoglobin subunit alpha

Gene

hbaa1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Iron (heme distal ligand)1
Metal bindingi89Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • response to hypoxia Source: ZFIN

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit alpha
Alternative name(s):
Alpha-globin aa1
Hemoglobin alpha chain
Gene namesi
Name:hbaa1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-980526-79 hbaa1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525852 – 143Hemoglobin subunit alphaAdd BLAST142

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ90487
PRIDEiQ90487

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSDARG00000097011

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101541

Structurei

3D structure databases

ProteinModelPortaliQ90487
SMRiQ90487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiQ90487
OMAiEAFGRML
OrthoDBiEOG091G0S0X
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002339 Haemoglobin_pi
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00815 PIHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90487-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSDTDKAV VKAIWAKISP KADEIGAEAL ARMLTVYPQT KTYFSHWADL
60 70 80 90 100
SPGSGPVKKH GKTIMGAVGE AISKIDDLVG GLAALSELHA FKLRVDPANF
110 120 130 140
KILSHNVIVV IAMLFPADFT PEVHVSVDKF FNNLALALSE KYR
Length:143
Mass (Da):15,522
Last modified:January 23, 2007 - v3
Checksum:iEFA41C735DAF161F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50381 Genomic DNA Translation: AAB05404.1
U50382 Genomic DNA Translation: AAB05406.1
AL929176 Genomic DNA Translation: CAE48986.1
UniGeneiDr.150234
Dr.76023

Genome annotation databases

EnsembliENSDART00000053078; ENSDARP00000053077; ENSDARG00000097011
ENSDART00000113098; ENSDARP00000101541; ENSDARG00000097011

Similar proteinsi

Entry informationi

Entry nameiHBA_DANRE
AccessioniPrimary (citable) accession number: Q90487
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health