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Protein

Hemoglobin subunit beta-1

Gene

ba1

more
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • oxygen transport Source: UniProtKB
  • response to hypoxia Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-1
Alternative name(s):
Beta-1-globin
Beta-A1-globin
Hemoglobin beta-1 chain
Gene namesi
Name:ba1
ORF Names:si:by187g17.2, zgc:123164
AND
Name:ba1l
ORF Names:si:by187g17.4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-990415-18. ba1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000528952 – 148Hemoglobin subunit beta-1Add BLAST147

Proteomic databases

PaxDbiQ90486.
PRIDEiQ90486.

Expressioni

Tissue specificityi

Red blood cells.Curated

Gene expression databases

BgeeiENSDARG00000089087.
ExpressionAtlasiQ90486. differential.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.Curated

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092488.

Structurei

3D structure databases

ProteinModelPortaliQ90486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiQ90486.
KOiK13825.
OMAiPTAIIGN.
OrthoDBiEOG091G0R7W.
TreeFamiTF333268.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEWTDAERT AILGLWGKLN IDEIGPQALS RCLIVYPWTQ RYFATFGNLS
60 70 80 90 100
SPAAIMGNPK VAAHGRTVMG GLERAIKNMD NVKNTYAALS VMHSEKLHVD
110 120 130 140
PDNFRLLADC ITVCAAMKFG QAGFNADVQE AWQKFLAVVV SALCRQYH
Length:148
Mass (Da):16,389
Last modified:January 23, 2007 - v3
Checksum:iBC359ACF623C7ED4
GO

Mass spectrometryi

Molecular mass is 16257.4 Da from positions 2 - 148. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50380 mRNA. Translation: AAB05403.1.
U50382 Genomic DNA. Translation: AAB05405.1.
AL929176 Genomic DNA. Translation: CAE48983.1.
AL929176 Genomic DNA. Translation: CAE48988.1.
BC107513 mRNA. Translation: AAI07514.1.
BC122092 mRNA. Translation: AAI22093.1.
RefSeqiNP_001013045.1. NM_001013027.1.
NP_571095.1. NM_131020.2.
UniGeneiDr.150237.
Dr.23445.

Genome annotation databases

EnsembliENSDART00000101713; ENSDARP00000092488; ENSDARG00000089087.
ENSDART00000128981; ENSDARP00000109859; ENSDARG00000089087.
ENSDART00000130869; ENSDARP00000109518; ENSDARG00000097238.
GeneIDi30216.
504174.
KEGGidre:30216.
dre:504174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50380 mRNA. Translation: AAB05403.1.
U50382 Genomic DNA. Translation: AAB05405.1.
AL929176 Genomic DNA. Translation: CAE48983.1.
AL929176 Genomic DNA. Translation: CAE48988.1.
BC107513 mRNA. Translation: AAI07514.1.
BC122092 mRNA. Translation: AAI22093.1.
RefSeqiNP_001013045.1. NM_001013027.1.
NP_571095.1. NM_131020.2.
UniGeneiDr.150237.
Dr.23445.

3D structure databases

ProteinModelPortaliQ90486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092488.

Proteomic databases

PaxDbiQ90486.
PRIDEiQ90486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000101713; ENSDARP00000092488; ENSDARG00000089087.
ENSDART00000128981; ENSDARP00000109859; ENSDARG00000089087.
ENSDART00000130869; ENSDARP00000109518; ENSDARG00000097238.
GeneIDi30216.
504174.
KEGGidre:30216.
dre:504174.

Organism-specific databases

CTDi100035484.
504174.
ZFINiZDB-GENE-990415-18. ba1.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiQ90486.
KOiK13825.
OMAiPTAIIGN.
OrthoDBiEOG091G0R7W.
TreeFamiTF333268.

Enzyme and pathway databases

ReactomeiR-DRE-6798695. Neutrophil degranulation.
R-DRE-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ90486.

Gene expression databases

BgeeiENSDARG00000089087.
ExpressionAtlasiQ90486. differential.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB1_DANRE
AccessioniPrimary (citable) accession number: Q90486
Secondary accession number(s): Q0P4G3, Q3B7Q0, Q90488
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.