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Protein

Hemoglobin subunit beta-1

Gene

ba1

more
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • hemopoiesis Source: UniProtKB
  • oxygen transport Source: UniProtKB
  • response to hypoxia Source: ZFIN

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-DRE-6798695 Neutrophil degranulation
R-DRE-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-1
Alternative name(s):
Beta-1-globin
Beta-A1-globin
Hemoglobin beta-1 chain
Gene namesi
Name:ba1
ORF Names:si:by187g17.2, zgc:123164
AND
Name:ba1l
ORF Names:si:by187g17.4
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-990415-18 hbba1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000528952 – 148Hemoglobin subunit beta-1Add BLAST147

Proteomic databases

PaxDbiQ90486
PRIDEiQ90486

Expressioni

Tissue specificityi

Red blood cells.Curated

Gene expression databases

BgeeiENSDARG00000089087
ExpressionAtlasiQ90486 baseline

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.Curated

Protein-protein interaction databases

STRINGi7955.ENSDARP00000092488

Structurei

3D structure databases

ProteinModelPortaliQ90486
SMRiQ90486
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiQ90486
KOiK13825
OMAiPTAIIGN
OrthoDBiEOG091G0R7W
TreeFamiTF333268

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEWTDAERT AILGLWGKLN IDEIGPQALS RCLIVYPWTQ RYFATFGNLS
60 70 80 90 100
SPAAIMGNPK VAAHGRTVMG GLERAIKNMD NVKNTYAALS VMHSEKLHVD
110 120 130 140
PDNFRLLADC ITVCAAMKFG QAGFNADVQE AWQKFLAVVV SALCRQYH
Length:148
Mass (Da):16,389
Last modified:January 23, 2007 - v3
Checksum:iBC359ACF623C7ED4
GO

Mass spectrometryi

Molecular mass is 16257.4 Da from positions 2 - 148. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50380 mRNA Translation: AAB05403.1
U50382 Genomic DNA Translation: AAB05405.1
AL929176 Genomic DNA Translation: CAE48983.1
AL929176 Genomic DNA Translation: CAE48988.1
BC107513 mRNA Translation: AAI07514.1
BC122092 mRNA Translation: AAI22093.1
RefSeqiNP_001013045.1, NM_001013027.1
NP_571095.1, NM_131020.2
UniGeneiDr.150237
Dr.23445

Genome annotation databases

EnsembliENSDART00000101713; ENSDARP00000092488; ENSDARG00000089087
ENSDART00000130869; ENSDARP00000109518; ENSDARG00000097238
GeneIDi30216
504174
KEGGidre:30216
dre:504174

Similar proteinsi

Entry informationi

Entry nameiHBB1_DANRE
AccessioniPrimary (citable) accession number: Q90486
Secondary accession number(s): Q0P4G3, Q3B7Q0, Q90488
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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