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Protein

POU domain, class 3, transcription factor 1

Gene

pou3f1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi279 – 338HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
POU domain protein 50
Short name:
ZP-50
Gene namesi
Name:pou3f1
Synonyms:pou50, zp50, zp50pou
ORF Names:si:dkey-248g17.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-980526-372 pou3f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007731 – 368POU domain, class 3, transcription factor 1Add BLAST368

Proteomic databases

PaxDbiQ90482

Expressioni

Tissue specificityi

Predominantly expressed in the embryonic and adult central nervous system.1 Publication

Developmental stagei

Expression starts between 10 and 12 hours post fecondation and is highest between 2 and 3 days after fertilization.1 Publication

Gene expression databases

BgeeiENSDARG00000009823

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000027757

Structurei

3D structure databases

ProteinModelPortaliQ90482
SMRiQ90482
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 261POU-specificPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG3802 Eukaryota
ENOG410XQ7X LUCA
GeneTreeiENSGT00760000118935
HOGENOMiHOG000116303
HOVERGENiHBG053120
InParanoidiQ90482
KOiK09365
OMAiMEDVYSQ
OrthoDBiEOG091G0U0S
PhylomeDBiQ90482
TreeFamiTF316413

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR010982 Lambda_DNA-bd_dom_sf
IPR013847 POU
IPR000327 POU_dom
IPR016362 TF_POU_3
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00157 Pou, 1 hit
PIRSFiPIRSF002629 Transcription_factor_POU, 1 hit
PRINTSiPR00028 POUDOMAIN
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00352 POU, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
SSF47413 SSF47413, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00035 POU_1, 1 hit
PS00465 POU_2, 1 hit
PS51179 POU_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q90482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTAQYIPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HHEYLQGLAT
60 70 80 90 100
NTGHPMSLTH HQWLPTSNTD WTSGTHIGQA EHNKASVQSR EDLGNGYHRS
110 120 130 140 150
HLVHQPTQNS HHGSWAPTTT HHLSPLSPAS NGHQSLVYSQ TGYTMLSPQP
160 170 180 190 200
SLHHGLRDPL HDDAGSHDNQ MESPQQPFSH HQDHSDEDAP SSDDLEQFAK
210 220 230 240 250
QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ LSFKNMCKLK
260 270 280 290 300
PLLNKWLEET DSNTGSPTNL DKIAAQGRKR KKRTSIEVGV KGALENHFLK
310 320 330 340 350
CPKPSAHEIT TLAGTLQLEK EVVRVWFCNR RQKEKRMTPV GVPHPTMEDV
360
YSQAETPPLH HTLQSPVQ
Length:368
Mass (Da):41,433
Last modified:November 1, 1996 - v1
Checksum:i6C40DCBF4B44386A
GO

Sequence cautioni

The sequence AAI52215 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103V → A in AAH66419 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96422 mRNA Translation: CAA65282.1
BX511161 Genomic DNA Translation: CAM12975.1
BC058306 mRNA Translation: AAH58306.1
BC066419 mRNA Translation: AAH66419.1
BC152214 mRNA Translation: AAI52215.1 Sequence problems.
RefSeqiNP_571236.1, NM_131161.1
UniGeneiDr.75088

Genome annotation databases

EnsembliENSDART00000013148; ENSDARP00000027757; ENSDARG00000009823
GeneIDi30398
KEGGidre:30398

Similar proteinsi

Entry informationi

Entry nameiPO3F1_DANRE
AccessioniPrimary (citable) accession number: Q90482
Secondary accession number(s): A2BGW5, A7MCK3, Q6NYY2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health