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Q90482 (PO3F1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
POU domain protein 50
Short name=ZP-50
Gene names
Name:pou3f1
Synonyms:pou50, zp50, zp50pou
ORF Names:si:dkey-248g17.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal. Ref.1

Subcellular location

Nucleus.

Tissue specificity

Predominantly expressed in the embryonic and adult central nervous system. Ref.1

Developmental stage

Expression starts between 10 and 12 hours post fecondation and is highest between 2 and 3 days after fertilization. Ref.1

Sequence similarities

Belongs to the POU transcription factor family. Class-3 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Sequence caution

The sequence AAI52215.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368POU domain, class 3, transcription factor 1
PRO_0000100773

Regions

Domain187 – 26175POU-specific
DNA binding279 – 33860Homeobox

Experimental info

Sequence conflict1031V → A in AAH66419. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q90482 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 6C40DCBF4B44386A

FASTA36841,433
        10         20         30         40         50         60 
MATTAQYIPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HHEYLQGLAT NTGHPMSLTH 

        70         80         90        100        110        120 
HQWLPTSNTD WTSGTHIGQA EHNKASVQSR EDLGNGYHRS HLVHQPTQNS HHGSWAPTTT 

       130        140        150        160        170        180 
HHLSPLSPAS NGHQSLVYSQ TGYTMLSPQP SLHHGLRDPL HDDAGSHDNQ MESPQQPFSH 

       190        200        210        220        230        240 
HQDHSDEDAP SSDDLEQFAK QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ 

       250        260        270        280        290        300 
LSFKNMCKLK PLLNKWLEET DSNTGSPTNL DKIAAQGRKR KKRTSIEVGV KGALENHFLK 

       310        320        330        340        350        360 
CPKPSAHEIT TLAGTLQLEK EVVRVWFCNR RQKEKRMTPV GVPHPTMEDV YSQAETPPLH 


HTLQSPVQ 

« Hide

References

« Hide 'large scale' references
[1]"Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog."
Hauptmann G., Gerster T.
Development 122:1769-1780(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Neurula.
[2]"The zebrafish reference genome sequence and its relationship to the human genome."
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J. expand/collapse author list , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tuebingen.
[3]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo and Larval eye.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X96422 mRNA. Translation: CAA65282.1.
BX511161 Genomic DNA. Translation: CAM12975.1.
BC058306 mRNA. Translation: AAH58306.1.
BC066419 mRNA. Translation: AAH66419.1.
BC152214 mRNA. Translation: AAI52215.1. Sequence problems.
RefSeqNP_571236.1. NM_131161.1.
UniGeneDr.75088.

3D structure databases

ProteinModelPortalQ90482.
SMRQ90482. Positions 193-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000027757.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000013148; ENSDARP00000027757; ENSDARG00000009823.
GeneID30398.
KEGGdre:30398.

Organism-specific databases

CTD5453.
ZFINZDB-GENE-980526-372. pou3f1.

Phylogenomic databases

eggNOGNOG261729.
GeneTreeENSGT00730000110809.
HOGENOMHOG000116303.
HOVERGENHBG053120.
InParanoidQ6NYY2.
KOK09365.
OMATGHPMSL.
OrthoDBEOG7DJSMG.
PhylomeDBQ90482.
TreeFamTF316413.

Gene expression databases

BgeeQ90482.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806809.
PROQ90482.

Entry information

Entry namePO3F1_DANRE
AccessionPrimary (citable) accession number: Q90482
Secondary accession number(s): A2BGW5, A7MCK3, Q6NYY2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families