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Q90482

- PO3F1_DANRE

UniProt

Q90482 - PO3F1_DANRE

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Protein
POU domain, class 3, transcription factor 1
Gene
pou3f1, pou50, zp50, zp50pou, si:dkey-248g17.1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi279 – 33860Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. nervous system development Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 3, transcription factor 1
Alternative name(s):
POU domain protein 50
Short name:
ZP-50
Gene namesi
Name:pou3f1
Synonyms:pou50, zp50, zp50pou
ORF Names:si:dkey-248g17.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 16

Organism-specific databases

ZFINiZDB-GENE-980526-372. pou3f1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368POU domain, class 3, transcription factor 1
PRO_0000100773Add
BLAST

Expressioni

Tissue specificityi

Predominantly expressed in the embryonic and adult central nervous system.1 Publication

Developmental stagei

Expression starts between 10 and 12 hours post fecondation and is highest between 2 and 3 days after fertilization.1 Publication

Gene expression databases

BgeeiQ90482.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000027757.

Structurei

3D structure databases

ProteinModelPortaliQ90482.
SMRiQ90482. Positions 193-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 26175POU-specific
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG261729.
GeneTreeiENSGT00730000110809.
HOGENOMiHOG000116303.
HOVERGENiHBG053120.
InParanoidiQ6NYY2.
KOiK09365.
OMAiTGHPMSL.
OrthoDBiEOG7DJSMG.
PhylomeDBiQ90482.
TreeFamiTF316413.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PIRSFiPIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90482-1 [UniParc]FASTAAdd to Basket

« Hide

MATTAQYIPR NNSLPSNPLM HPDSDRMHQG TTYREVQKMM HHEYLQGLAT    50
NTGHPMSLTH HQWLPTSNTD WTSGTHIGQA EHNKASVQSR EDLGNGYHRS 100
HLVHQPTQNS HHGSWAPTTT HHLSPLSPAS NGHQSLVYSQ TGYTMLSPQP 150
SLHHGLRDPL HDDAGSHDNQ MESPQQPFSH HQDHSDEDAP SSDDLEQFAK 200
QFKQRRIKLG FTQADVGLAL GTLYGNVFSQ TTICRFEALQ LSFKNMCKLK 250
PLLNKWLEET DSNTGSPTNL DKIAAQGRKR KKRTSIEVGV KGALENHFLK 300
CPKPSAHEIT TLAGTLQLEK EVVRVWFCNR RQKEKRMTPV GVPHPTMEDV 350
YSQAETPPLH HTLQSPVQ 368
Length:368
Mass (Da):41,433
Last modified:November 1, 1996 - v1
Checksum:i6C40DCBF4B44386A
GO

Sequence cautioni

The sequence AAI52215.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031V → A in AAH66419. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96422 mRNA. Translation: CAA65282.1.
BX511161 Genomic DNA. Translation: CAM12975.1.
BC058306 mRNA. Translation: AAH58306.1.
BC066419 mRNA. Translation: AAH66419.1.
BC152214 mRNA. Translation: AAI52215.1. Sequence problems.
RefSeqiNP_571236.1. NM_131161.1.
UniGeneiDr.75088.

Genome annotation databases

EnsembliENSDART00000013148; ENSDARP00000027757; ENSDARG00000009823.
GeneIDi30398.
KEGGidre:30398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X96422 mRNA. Translation: CAA65282.1 .
BX511161 Genomic DNA. Translation: CAM12975.1 .
BC058306 mRNA. Translation: AAH58306.1 .
BC066419 mRNA. Translation: AAH66419.1 .
BC152214 mRNA. Translation: AAI52215.1 . Sequence problems.
RefSeqi NP_571236.1. NM_131161.1.
UniGenei Dr.75088.

3D structure databases

ProteinModelPortali Q90482.
SMRi Q90482. Positions 193-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000027757.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000013148 ; ENSDARP00000027757 ; ENSDARG00000009823 .
GeneIDi 30398.
KEGGi dre:30398.

Organism-specific databases

CTDi 5453.
ZFINi ZDB-GENE-980526-372. pou3f1.

Phylogenomic databases

eggNOGi NOG261729.
GeneTreei ENSGT00730000110809.
HOGENOMi HOG000116303.
HOVERGENi HBG053120.
InParanoidi Q6NYY2.
KOi K09365.
OMAi TGHPMSL.
OrthoDBi EOG7DJSMG.
PhylomeDBi Q90482.
TreeFami TF316413.

Miscellaneous databases

NextBioi 20806809.
PROi Q90482.

Gene expression databases

Bgeei Q90482.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
IPR016362. Transcription_factor_POU.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view ]
PIRSFi PIRSF002629. Transcription_factor_POU. 1 hit.
PRINTSi PR00028. POUDOMAIN.
SMARTi SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complex expression of the zp-50 pou gene in the embryonic zebrafish brain is altered by overexpression of sonic hedgehog."
    Hauptmann G., Gerster T.
    Development 122:1769-1780(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Neurula.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo and Larval eye.

Entry informationi

Entry nameiPO3F1_DANRE
AccessioniPrimary (citable) accession number: Q90482
Secondary accession number(s): A2BGW5, A7MCK3, Q6NYY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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