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Protein

Homeobox protein Nkx-2.2a

Gene

nkx2.2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi125 – 184HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • endocrine pancreas development Source: ZFIN
  • floor plate development Source: ZFIN
  • floor plate formation Source: ZFIN
  • glial cell migration Source: ZFIN
  • motor neuron axon guidance Source: ZFIN
  • regulation of transcription, DNA-templated Source: InterPro
  • Schwann cell development Source: ZFIN
  • spinal cord oligodendrocyte cell differentiation Source: ZFIN
  • spinal cord oligodendrocyte cell fate specification Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.2a
Alternative name(s):
Homeobox protein NK-2 homolog B-A
Gene namesi
Name:nkx2.2a
Synonyms:nk2.2, nkx2-2, nkx2.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-403. nkx2.2a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000489321 – 269Homeobox protein Nkx-2.2aAdd BLAST269

Proteomic databases

PaxDbiQ90481.

Expressioni

Tissue specificityi

Expressed in a continuous narrow band of cells along a boundary zone demarcating the location at which two of the earliest nuclei in the brain differentiate.

Gene expression databases

BgeeiENSDARG00000053298.
ExpressionAtlasiQ90481. baseline.

Interactioni

Protein-protein interaction databases

BioGridi78852. 2 interactors.
STRINGi7955.ENSDARP00000117693.

Structurei

3D structure databases

ProteinModelPortaliQ90481.
SMRiQ90481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00870000136367.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ90481.
PhylomeDBiQ90481.
TreeFamiTF351204.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNTKTGF SVKDILDLPD TNDEEGSITG TEEDTEGSEA TKTPGVLVQS
60 70 80 90 100
PLENVQNLPL KNPFYDNSDN PYTRWLATTD SIQYSLHGLS ANSQDTSAKS
110 120 130 140 150
PEPSADESPD NDKETSSNGS DSGKKRKRRV LFSKAQTYEL ERRFRQQRYL
160 170 180 190 200
SAPEREHLAS LIRLTPTQVK IWFQNHRYKM KRARAEKGME VTHLPSPRRV
210 220 230 240 250
AVPVLVRDGK PCHTLKAQDL AATFQAGIPF SAYSAQSLQH MQYNAHYSAA
260
TTPQFPTAHH LVQTQQWTW
Length:269
Mass (Da):30,307
Last modified:November 1, 1996 - v1
Checksum:iCF006285CDD33D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85977 mRNA. Translation: CAA59967.1.
PIRiI50504.
UniGeneiDr.75083.

Genome annotation databases

EnsembliENSDART00000081396; ENSDARP00000075838; ENSDARG00000053298.

Similar proteinsi

Entry informationi

Entry nameiNX22A_DANRE
AccessioniPrimary (citable) accession number: Q90481
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families