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Protein

Homeobox protein Nkx-2.2a

Gene

nkx2.2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi125 – 18460HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • endocrine pancreas development Source: ZFIN
  • floor plate development Source: ZFIN
  • floor plate formation Source: ZFIN
  • glial cell migration Source: ZFIN
  • motor neuron axon guidance Source: ZFIN
  • regulation of transcription, DNA-templated Source: InterPro
  • Schwann cell development Source: ZFIN
  • spinal cord oligodendrocyte cell differentiation Source: ZFIN
  • spinal cord oligodendrocyte cell fate specification Source: ZFIN
  • ventral spinal cord interneuron differentiation Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DRE-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.2a
Alternative name(s):
Homeobox protein NK-2 homolog B-A
Gene namesi
Name:nkx2.2a
Synonyms:nk2.2, nkx2-2, nkx2.2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 17

Organism-specific databases

ZFINiZDB-GENE-980526-403. nkx2.2a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Homeobox protein Nkx-2.2aPRO_0000048932Add
BLAST

Proteomic databases

PaxDbiQ90481.

Expressioni

Tissue specificityi

Expressed in a continuous narrow band of cells along a boundary zone demarcating the location at which two of the earliest nuclei in the brain differentiate.

Gene expression databases

BgeeiENSDARG00000053298.

Interactioni

Protein-protein interaction databases

BioGridi78852. 2 interactions.
STRINGi7955.ENSDARP00000117693.

Structurei

3D structure databases

ProteinModelPortaliQ90481.
SMRiQ90481. Positions 124-190.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-2 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00840000129671.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ90481.
PhylomeDBiQ90481.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90481-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTNTKTGF SVKDILDLPD TNDEEGSITG TEEDTEGSEA TKTPGVLVQS
60 70 80 90 100
PLENVQNLPL KNPFYDNSDN PYTRWLATTD SIQYSLHGLS ANSQDTSAKS
110 120 130 140 150
PEPSADESPD NDKETSSNGS DSGKKRKRRV LFSKAQTYEL ERRFRQQRYL
160 170 180 190 200
SAPEREHLAS LIRLTPTQVK IWFQNHRYKM KRARAEKGME VTHLPSPRRV
210 220 230 240 250
AVPVLVRDGK PCHTLKAQDL AATFQAGIPF SAYSAQSLQH MQYNAHYSAA
260
TTPQFPTAHH LVQTQQWTW
Length:269
Mass (Da):30,307
Last modified:November 1, 1996 - v1
Checksum:iCF006285CDD33D63
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85977 mRNA. Translation: CAA59967.1.
PIRiI50504.
UniGeneiDr.75083.

Genome annotation databases

EnsembliENSDART00000081396; ENSDARP00000075838; ENSDARG00000053298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85977 mRNA. Translation: CAA59967.1.
PIRiI50504.
UniGeneiDr.75083.

3D structure databases

ProteinModelPortaliQ90481.
SMRiQ90481. Positions 124-190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78852. 2 interactions.
STRINGi7955.ENSDARP00000117693.

Proteomic databases

PaxDbiQ90481.

Protocols and materials databases

DNASUi30697.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000081396; ENSDARP00000075838; ENSDARG00000053298.

Organism-specific databases

ZFINiZDB-GENE-980526-403. nkx2.2a.

Phylogenomic databases

eggNOGiKOG0842. Eukaryota.
ENOG410XR21. LUCA.
GeneTreeiENSGT00840000129671.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiQ90481.
PhylomeDBiQ90481.
TreeFamiTF351204.

Enzyme and pathway databases

ReactomeiR-DRE-210746. Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.

Miscellaneous databases

PROiQ90481.

Gene expression databases

BgeeiENSDARG00000053298.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNX22A_DANRE
AccessioniPrimary (citable) accession number: Q90481
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.