Q90471 (HXDCA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D12a
Short name=Hox-D12

Gene names

Name:	hoxd12a
Synonyms:	hox-d12, hoxd12

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Danio

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus.
Developmental stage	First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf. Ref.1
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Sequence caution	The sequence CAA61032.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAA61032.1 differs from that shown. Reason: Frameshift at position 165. The sequence CAA74882.1 differs from that shown. Reason: Frameshift at position 257.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Homeobox protein Hox-D12a		PRO_0000200241
Regions
	DNA binding	194 – 253	60	Homeobox
Experimental info
	Sequence conflict	219 – 220	2	IN → MT Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q90471 [UniParc]. Last modified October 3, 2006. Version 2. Checksum: 151D52E1DCB8802A	FASTA	262	29,739
	10 20 30 40 50 60 MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC SLPWSSSNSC 70 80 90 100 110 120 TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR YYFQDVSHKS EEPGRPNAAY 130 140 150 160 170 180 ASEQSSASNG LSNLERRQLN AVAPNELSCI EQPESDASKQ SVSSIAPFQP SLSAQNIRPA 190 200 210 220 230 240 FTDGLPWCPS QVRSRKKRKP YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI 250 260 WFQNRRMKKK RLMMREHTFT IY

References

[1]	"Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex." van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C., Duboule D. Mech. Dev. 54:9-21(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
[2]	"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a." Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K. Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-204. Strain: Tuebingen.
[3]	"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk." Prince V.E., Joly L., Ekker M., Ho R.K. Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-262. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems. DQ069273 mRNA. Translation: AAY87055.1. Y14547 mRNA. Translation: CAA74882.1. Frameshift.
IPI	IPI00499135.
UniGene	Dr.151901. Dr.75799.
3D structure databases
ProteinModelPortal	Q90471.
ModBase	Search...
Protein-protein interaction databases
STRING	7955.ENSDARP00000101534.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
Organism-specific databases
ZFIN	ZDB-GENE-990415-118. hoxd12a.
Phylogenomic databases
eggNOG	NOG241833.
GeneTree	ENSGT00700000104263.
HOVERGEN	HBG052050.
InParanoid	Q90471.
OrthoDB	EOG43N7DG.
Gene expression databases
ArrayExpress	Q90471.
Bgee	Q90471.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXDCA_DANRE

Accession

Primary (citable) accession number: Q90471
Secondary accession number(s): O57373, Q4JMC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	October 3, 2006
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program