Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q90471

- HXDCA_DANRE

UniProt

Q90471 - HXDCA_DANRE

Protein

Homeobox protein Hox-D12a

Gene

hoxd12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D12a
    Short name:
    Hox-D12
    Gene namesi
    Name:hoxd12a
    Synonyms:hox-d12, hoxd12
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-990415-118. hoxd12a.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Homeobox protein Hox-D12aPRO_0000200241Add
    BLAST

    Expressioni

    Developmental stagei

    First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.1 Publication

    Gene expression databases

    BgeeiQ90471.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000101534.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90471.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG241833.
    GeneTreeiENSGT00750000117432.
    HOVERGENiHBG052050.
    InParanoidiQ90471.
    KOiK09297.
    OrthoDBiEOG73FQNH.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90471-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC    50
    SLPWSSSNSC TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR 100
    YYFQDVSHKS EEPGRPNAAY ASEQSSASNG LSNLERRQLN AVAPNELSCI 150
    EQPESDASKQ SVSSIAPFQP SLSAQNIRPA FTDGLPWCPS QVRSRKKRKP 200
    YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI WFQNRRMKKK 250
    RLMMREHTFT IY 262
    Length:262
    Mass (Da):29,739
    Last modified:October 3, 2006 - v2
    Checksum:i151D52E1DCB8802A
    GO

    Sequence cautioni

    The sequence CAA61032.1 differs from that shown. Reason: Frameshift at position 165.
    The sequence CAA74882.1 differs from that shown. Reason: Frameshift at position 257.
    The sequence CAA61032.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2202IN → MT(PubMed:9425136)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
    DQ069273 mRNA. Translation: AAY87055.1.
    Y14547 mRNA. Translation: CAA74882.1. Frameshift.
    RefSeqiXP_005172570.1. XM_005172513.1.
    UniGeneiDr.151901.
    Dr.75799.

    Genome annotation databases

    EnsembliENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
    GeneIDi100006598.
    KEGGidre:100006598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87753 Genomic DNA. Translation: CAA61032.1 . Sequence problems.
    DQ069273 mRNA. Translation: AAY87055.1 .
    Y14547 mRNA. Translation: CAA74882.1 . Frameshift.
    RefSeqi XP_005172570.1. XM_005172513.1.
    UniGenei Dr.151901.
    Dr.75799.

    3D structure databases

    ProteinModelPortali Q90471.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000101534.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000142842 ; ENSDARP00000121699 ; ENSDARG00000059263 .
    GeneIDi 100006598.
    KEGGi dre:100006598.

    Organism-specific databases

    CTDi 100006598.
    ZFINi ZDB-GENE-990415-118. hoxd12a.

    Phylogenomic databases

    eggNOGi NOG241833.
    GeneTreei ENSGT00750000117432.
    HOVERGENi HBG052050.
    InParanoidi Q90471.
    KOi K09297.
    OrthoDBi EOG73FQNH.

    Miscellaneous databases

    PROi Q90471.

    Gene expression databases

    Bgeei Q90471.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex."
      van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C., Duboule D.
      Mech. Dev. 54:9-21(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
    2. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
      Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
      Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-204.
      Strain: Tuebingen.
    3. "Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
      Prince V.E., Joly L., Ekker M., Ho R.K.
      Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-262.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHXDCA_DANRE
    AccessioniPrimary (citable) accession number: Q90471
    Secondary accession number(s): O57373, Q4JMC8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3