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Q90471 (HXDCA_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D12a

Short name=Hox-D12
Gene names
Name:hoxd12a
Synonyms:hox-d12, hoxd12
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus.

Developmental stage

First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf. Ref.1

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence CAA61032.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAA61032.1 differs from that shown. Reason: Frameshift at position 165.

The sequence CAA74882.1 differs from that shown. Reason: Frameshift at position 257.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Homeobox protein Hox-D12a
PRO_0000200241

Regions

DNA binding194 – 25360Homeobox

Experimental info

Sequence conflict219 – 2202IN → MT Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q90471 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: 151D52E1DCB8802A

FASTA26229,739
        10         20         30         40         50         60 
MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC SLPWSSSNSC 

        70         80         90        100        110        120 
TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR YYFQDVSHKS EEPGRPNAAY 

       130        140        150        160        170        180 
ASEQSSASNG LSNLERRQLN AVAPNELSCI EQPESDASKQ SVSSIAPFQP SLSAQNIRPA 

       190        200        210        220        230        240 
FTDGLPWCPS QVRSRKKRKP YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI 

       250        260 
WFQNRRMKKK RLMMREHTFT IY 

« Hide

References

[1]"Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex."
van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C., Duboule D.
Mech. Dev. 54:9-21(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
[2]"Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
Evol. Dev. 7:362-375(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-204.
Strain: Tuebingen.
[3]"Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
Prince V.E., Joly L., Ekker M., Ho R.K.
Development 125:407-420(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-262.
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
DQ069273 mRNA. Translation: AAY87055.1.
Y14547 mRNA. Translation: CAA74882.1. Frameshift.
RefSeqXP_005172570.1. XM_005172513.1.
UniGeneDr.151901.
Dr.75799.

3D structure databases

ProteinModelPortalQ90471.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000101534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
GeneID100006598.
KEGGdre:100006598.

Organism-specific databases

CTD100006598.
ZFINZDB-GENE-990415-118. hoxd12a.

Phylogenomic databases

eggNOGNOG241833.
GeneTreeENSGT00750000117432.
HOVERGENHBG052050.
InParanoidQ90471.
KOK09297.
OrthoDBEOG73FQNH.

Gene expression databases

BgeeQ90471.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ90471.

Entry information

Entry nameHXDCA_DANRE
AccessionPrimary (citable) accession number: Q90471
Secondary accession number(s): O57373, Q4JMC8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2006
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries