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Protein

Homeobox protein Hox-D12a

Gene

hoxd12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi194 – 253HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12a
Short name:
Hox-D12
Gene namesi
Name:hoxd12a
Synonyms:hox-d12, hoxd12
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-118. hoxd12a.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002411 – 262Homeobox protein Hox-D12aAdd BLAST262

Proteomic databases

PRIDEiQ90471.

Expressioni

Developmental stagei

First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000059263.
ExpressionAtlasiQ90471. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ90471.
SMRiQ90471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00760000118834.
HOVERGENiHBG052050.
InParanoidiQ90471.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC
60 70 80 90 100
SLPWSSSNSC TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR
110 120 130 140 150
YYFQDVSHKS EEPGRPNAAY ASEQSSASNG LSNLERRQLN AVAPNELSCI
160 170 180 190 200
EQPESDASKQ SVSSIAPFQP SLSAQNIRPA FTDGLPWCPS QVRSRKKRKP
210 220 230 240 250
YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI WFQNRRMKKK
260
RLMMREHTFT IY
Length:262
Mass (Da):29,739
Last modified:October 3, 2006 - v2
Checksum:i151D52E1DCB8802A
GO

Sequence cautioni

The sequence CAA61032 differs from that shown. Reason: Frameshift at position 165.Curated
The sequence CAA61032 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAA74882 differs from that shown. Reason: Frameshift at position 257.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219 – 220IN → MT (PubMed:9425136).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
DQ069273 mRNA. Translation: AAY87055.1.
Y14547 mRNA. Translation: CAA74882.1. Frameshift.
RefSeqiXP_005172570.1. XM_005172513.3.
UniGeneiDr.151901.
Dr.75799.

Genome annotation databases

EnsembliENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
ENSDART00000165502; ENSDARP00000129883; ENSDARG00000059263.
GeneIDi100006598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
DQ069273 mRNA. Translation: AAY87055.1.
Y14547 mRNA. Translation: CAA74882.1. Frameshift.
RefSeqiXP_005172570.1. XM_005172513.3.
UniGeneiDr.151901.
Dr.75799.

3D structure databases

ProteinModelPortaliQ90471.
SMRiQ90471.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90471.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
ENSDART00000165502; ENSDARP00000129883; ENSDARG00000059263.
GeneIDi100006598.

Organism-specific databases

CTDi100006598.
ZFINiZDB-GENE-990415-118. hoxd12a.

Phylogenomic databases

GeneTreeiENSGT00760000118834.
HOVERGENiHBG052050.
InParanoidiQ90471.

Miscellaneous databases

PROiQ90471.

Gene expression databases

BgeeiENSDARG00000059263.
ExpressionAtlasiQ90471. baseline.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHXDCA_DANRE
AccessioniPrimary (citable) accession number: Q90471
Secondary accession number(s): O57373, Q4JMC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: October 3, 2006
Last modified: February 15, 2017
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.