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Protein

Homeobox protein Hox-D12a

Gene

hoxd12a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D12a
Short name:
Hox-D12
Gene namesi
Name:hoxd12a
Synonyms:hox-d12, hoxd12
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-118. hoxd12a.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Homeobox protein Hox-D12aPRO_0000200241Add
BLAST

Expressioni

Developmental stagei

First expressed at 14 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 17. Also expressed in the developing hindgut, except in the most distal portion. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.1 Publication

Gene expression databases

BgeeiQ90471.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101534.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG052050.
InParanoidiQ90471.
KOiK09297.
OrthoDBiEOG73FQNH.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90471-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCEHNLLSSG YVAPLLNFHS PDSLYLQNLR GNGVHLSGLP QMSYSRREVC
60 70 80 90 100
SLPWSSSNSC TAPAQSRAYS GYSQPFFSNS AAVSASLNTH KKGSLEESGR
110 120 130 140 150
YYFQDVSHKS EEPGRPNAAY ASEQSSASNG LSNLERRQLN AVAPNELSCI
160 170 180 190 200
EQPESDASKQ SVSSIAPFQP SLSAQNIRPA FTDGLPWCPS QVRSRKKRKP
210 220 230 240 250
YTKPQLTELE NEFMMNEFIN RQKRKELSDR LELSDQQVKI WFQNRRMKKK
260
RLMMREHTFT IY
Length:262
Mass (Da):29,739
Last modified:October 2, 2006 - v2
Checksum:i151D52E1DCB8802A
GO

Sequence cautioni

The sequence CAA61032.1 differs from that shown. Reason: Frameshift at position 165. Curated
The sequence CAA61032.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAA74882.1 differs from that shown. Reason: Frameshift at position 257. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2202IN → MT (PubMed:9425136).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
DQ069273 mRNA. Translation: AAY87055.1.
Y14547 mRNA. Translation: CAA74882.1. Frameshift.
RefSeqiXP_005172570.1. XM_005172513.2.
UniGeneiDr.151901.
Dr.75799.

Genome annotation databases

EnsembliENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
GeneIDi100006598.
KEGGidre:100006598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87753 Genomic DNA. Translation: CAA61032.1. Sequence problems.
DQ069273 mRNA. Translation: AAY87055.1.
Y14547 mRNA. Translation: CAA74882.1. Frameshift.
RefSeqiXP_005172570.1. XM_005172513.2.
UniGeneiDr.151901.
Dr.75799.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000101534.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000142842; ENSDARP00000121699; ENSDARG00000059263.
GeneIDi100006598.
KEGGidre:100006598.

Organism-specific databases

CTDi100006598.
ZFINiZDB-GENE-990415-118. hoxd12a.

Phylogenomic databases

eggNOGiNOG241833.
GeneTreeiENSGT00760000118834.
HOVERGENiHBG052050.
InParanoidiQ90471.
KOiK09297.
OrthoDBiEOG73FQNH.

Miscellaneous databases

PROiQ90471.

Gene expression databases

BgeeiQ90471.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex."
    van der Hoeven F., Sordino P., Fraudeau N., Izpisua-Belmonte J.-C., Duboule D.
    Mech. Dev. 54:9-21(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE.
  2. "Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a."
    Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T., de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J., Richardson M.K.
    Evol. Dev. 7:362-375(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 73-204.
    Strain: Tuebingen.
  3. "Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk."
    Prince V.E., Joly L., Ekker M., Ho R.K.
    Development 125:407-420(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-262.
    Tissue: Embryo.

Entry informationi

Entry nameiHXDCA_DANRE
AccessioniPrimary (citable) accession number: Q90471
Secondary accession number(s): O57373, Q4JMC8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 1998
Last sequence update: October 2, 2006
Last modified: March 31, 2015
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.