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Protein

Homeobox protein Hox-D11a

Gene

hoxd11a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi204 – 26360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11a
Short name:
Hox-D11
Alternative name(s):
Homeobox protein Hox-C11
Gene namesi
Name:hoxd11a
Synonyms:hoxc11, hoxd11
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-117. hoxd11a.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Homeobox protein Hox-D11aPRO_0000200234Add
BLAST

Proteomic databases

PaxDbiQ90470.

Expressioni

Developmental stagei

First expressed at 12 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 11. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000059267.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076780.

Structurei

3D structure databases

ProteinModelPortaliQ90470.
SMRiQ90470. Positions 201-266.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiQ90470.
KOiK09296.
OMAiDTEIESH.
OrthoDBiEOG091G12E6.
PhylomeDBiQ90470.
TreeFamiTF350668.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDYDDRNNC ASNMYLPYYV STPDFSSVSS FLPQTTSCQV NFPYSSNIAQ
60 70 80 90 100
VQPVREVTFR DYGLDHPSKW HYRGNYASYY STEEIMHRDL LQSTNRAEMI
110 120 130 140 150
FKNDSMYSHH AGTNSSCSFF TNVGRNGVLP QGFDQFFETA NSEKPNPEQS
160 170 180 190 200
KQKPDTSVPG DAACNPSTDS AEQTKQDPTD TVEEESSVST CDEEKNSGSS
210 220 230 240 250
ATKSRKKRCP YSKYQIRELE REFFFNVYIN KEKRLQLSRM LSLTDRQVKI
260 270
WFQNRRMKEK KLNRDRLQYF TGNPLF
Length:276
Mass (Da):32,046
Last modified:October 3, 2006 - v2
Checksum:i3BA87811125F0088
GO

Sequence cautioni

The sequence AAI14272 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA74878 differs from that shown. Reason: Erroneous termination at position 277. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti229 – 2291I → M (PubMed:9425136).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114271 mRNA. Translation: AAI14272.1. Different initiation.
X87751 Genomic DNA. Translation: CAA61030.1.
DQ069272 mRNA. Translation: AAY87054.1.
Y14543 mRNA. Translation: CAA74878.1. Sequence problems.
RefSeqiNP_571242.1. NM_131167.1.
UniGeneiDr.47548.

Genome annotation databases

EnsembliENSDART00000082344; ENSDARP00000076780; ENSDARG00000059267.
GeneIDi30405.
KEGGidre:30405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114271 mRNA. Translation: AAI14272.1. Different initiation.
X87751 Genomic DNA. Translation: CAA61030.1.
DQ069272 mRNA. Translation: AAY87054.1.
Y14543 mRNA. Translation: CAA74878.1. Sequence problems.
RefSeqiNP_571242.1. NM_131167.1.
UniGeneiDr.47548.

3D structure databases

ProteinModelPortaliQ90470.
SMRiQ90470. Positions 201-266.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076780.

Proteomic databases

PaxDbiQ90470.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000082344; ENSDARP00000076780; ENSDARG00000059267.
GeneIDi30405.
KEGGidre:30405.

Organism-specific databases

CTDi30405.
ZFINiZDB-GENE-990415-117. hoxd11a.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231898.
HOVERGENiHBG052048.
InParanoidiQ90470.
KOiK09296.
OMAiDTEIESH.
OrthoDBiEOG091G12E6.
PhylomeDBiQ90470.
TreeFamiTF350668.

Miscellaneous databases

PROiQ90470.

Gene expression databases

BgeeiENSDARG00000059267.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR021918. DUF3528.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF12045. DUF3528. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXDBA_DANRE
AccessioniPrimary (citable) accession number: Q90470
Secondary accession number(s): O57372, Q29RC6, Q4JMC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 3, 2006
Last modified: September 7, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.