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Protein

Homeobox protein Hox-D11a

Gene

hoxd11a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi204 – 263HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D11a
Short name:
Hox-D11
Alternative name(s):
Homeobox protein Hox-C11
Gene namesi
Name:hoxd11a
Synonyms:hoxc11, hoxd11
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-117 hoxd11a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002341 – 276Homeobox protein Hox-D11aAdd BLAST276

Proteomic databases

PaxDbiQ90470
PRIDEiQ90470

Expressioni

Developmental stagei

First expressed at 12 hours post-fertilization (hpf) in the dorsal pre-somitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 11. At 24-26 hpf, posterior expression begin to weaken and is undetectable by 40-56 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000059267

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000076780

Structurei

3D structure databases

ProteinModelPortaliQ90470
SMRiQ90470
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487 Eukaryota
ENOG4111FJP LUCA
GeneTreeiENSGT00910000143984
HOGENOMiHOG000231898
HOVERGENiHBG052048
InParanoidiQ90470
KOiK09296
OMAiCAYYVSP
OrthoDBiEOG091G12E6
PhylomeDBiQ90470
TreeFamiTF350668

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR021918 DUF3528
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF12045 DUF3528, 1 hit
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90470-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDYDDRNNC ASNMYLPYYV STPDFSSVSS FLPQTTSCQV NFPYSSNIAQ
60 70 80 90 100
VQPVREVTFR DYGLDHPSKW HYRGNYASYY STEEIMHRDL LQSTNRAEMI
110 120 130 140 150
FKNDSMYSHH AGTNSSCSFF TNVGRNGVLP QGFDQFFETA NSEKPNPEQS
160 170 180 190 200
KQKPDTSVPG DAACNPSTDS AEQTKQDPTD TVEEESSVST CDEEKNSGSS
210 220 230 240 250
ATKSRKKRCP YSKYQIRELE REFFFNVYIN KEKRLQLSRM LSLTDRQVKI
260 270
WFQNRRMKEK KLNRDRLQYF TGNPLF
Length:276
Mass (Da):32,046
Last modified:October 3, 2006 - v2
Checksum:i3BA87811125F0088
GO

Sequence cautioni

The sequence AAI14272 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAA74878 differs from that shown. Reason: Erroneous termination at position 277. Translated as stop.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229I → M (PubMed:9425136).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC114271 mRNA Translation: AAI14272.1 Different initiation.
X87751 Genomic DNA Translation: CAA61030.1
DQ069272 mRNA Translation: AAY87054.1
Y14543 mRNA Translation: CAA74878.1 Sequence problems.
RefSeqiNP_571242.1, NM_131167.1
UniGeneiDr.47548

Genome annotation databases

EnsembliENSDART00000082344; ENSDARP00000076780; ENSDARG00000059267
GeneIDi30405
KEGGidre:30405

Similar proteinsi

Entry informationi

Entry nameiHXDBA_DANRE
AccessioniPrimary (citable) accession number: Q90470
Secondary accession number(s): O57372, Q29RC6, Q4JMC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 3, 2006
Last modified: May 23, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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