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Protein

Homeobox protein Hox-D10a

Gene

hoxd10a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi258 – 317HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D10a
Short name:
Hox-D10
Alternative name(s):
Homeobox protein Hox-C10
Gene namesi
Name:hoxd10a
Synonyms:hoxc10, hoxd10
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-116. hoxd10a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002291 – 332Homeobox protein Hox-D10aAdd BLAST332

Proteomic databases

PaxDbiQ90469.

Expressioni

Developmental stagei

First expressed at 11 hours post-fertilization (hpf) in the dorsal presomitic mesoderm and neural keel at posterior levels, extending into the ventral somitic mesoderm during budding. At 22-26 hpf, expression decreases in the lateral and ventral mesoderm, but is maintained in the neural rod. Expression decreases from posterior to anterior with an anterior expression limit at somite 9. At 24-26 hpf, posterior expression begins to weaken and is undetectable by 40-56 hpf.1 Publication

Gene expression databases

BgeeiENSDARG00000057859.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109229.

Structurei

3D structure databases

ProteinModelPortaliQ90469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiQ90469.
KOiK09295.
OMAiNPRGSAK.
OrthoDBiEOG091G0LON.
PhylomeDBiQ90469.
TreeFamiTF317819.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPNSSPAA NTFLVDSLIG ACRTDFYSSS NMYMPAATAE MGTYGMQTCG
60 70 80 90 100
LLPALGKRGE VNHQNMDMTV HSYIPQTDTW ADPSRSCRLE QPLNQMSTCT
110 120 130 140 150
FSQSIKEETN CCMYSDKRAK VSSSEIPAYS SLIPESCSVD SPEIPVPGYF
160 170 180 190 200
RLSQTYATAK NPDYDNETMS PNTTLMQLNR ATPKAQSTPF VEVEKKLAHD
210 220 230 240 250
RDTRSSSPAQ SPEPKVSTLE EKNCSTEASV SSPELPHREG KESKNDTPTS
260 270 280 290 300
NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE ISKSVNLTDR
310 320 330
QVKIWFQNRR MKLKKMSREN RIRELTSNLT FS
Length:332
Mass (Da):37,592
Last modified:October 5, 2010 - v4
Checksum:i7ABE463B49EB273B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17Missing in CAA61029 (PubMed:8808402).Curated1
Sequence conflicti198 – 200AHD → RTI in CAA61029 (PubMed:8808402).Curated3
Sequence conflicti215K → Q in AAB38626 (PubMed:8917540).Curated1
Sequence conflicti241K → KA in CAA61029 (PubMed:8808402).Curated1
Sequence conflicti292S → T in AAB38643 (PubMed:8917540).Curated1
Sequence conflicti296N → S in CAA61029 (PubMed:8808402).Curated1
Sequence conflicti301Q → R in CAA74877 (PubMed:9425136).Curated1
Sequence conflicti330T → N in CAA61029 (PubMed:8808402).Curated1
Sequence conflicti330T → N in CAA74877 (PubMed:9425136).Curated1
Sequence conflicti332S → FVSTQNKCKSKT in CAA61029 (PubMed:8808402).Curated1
Sequence conflicti332S → FVSTQNKCKSKT in CAA74877 (PubMed:9425136).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87750 Genomic DNA. Translation: CAA61029.1.
BX322661 Genomic DNA. Translation: CAQ15519.1.
BC071329 mRNA. Translation: AAH71329.1.
BC153658 mRNA. Translation: AAI53659.1.
U51403 Genomic DNA. Translation: AAB38626.1.
U51421 Genomic DNA. Translation: AAB38643.1.
Y14542 mRNA. Translation: CAA74877.1.
RefSeqiNP_571241.2. NM_131166.2.
UniGeneiDr.75795.

Genome annotation databases

EnsembliENSDART00000080608; ENSDARP00000075055; ENSDARG00000057859.
GeneIDi30404.
KEGGidre:30404.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87750 Genomic DNA. Translation: CAA61029.1.
BX322661 Genomic DNA. Translation: CAQ15519.1.
BC071329 mRNA. Translation: AAH71329.1.
BC153658 mRNA. Translation: AAI53659.1.
U51403 Genomic DNA. Translation: AAB38626.1.
U51421 Genomic DNA. Translation: AAB38643.1.
Y14542 mRNA. Translation: CAA74877.1.
RefSeqiNP_571241.2. NM_131166.2.
UniGeneiDr.75795.

3D structure databases

ProteinModelPortaliQ90469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109229.

Proteomic databases

PaxDbiQ90469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000080608; ENSDARP00000075055; ENSDARG00000057859.
GeneIDi30404.
KEGGidre:30404.

Organism-specific databases

CTDi30404.
ZFINiZDB-GENE-990415-116. hoxd10a.

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231182.
HOVERGENiHBG052934.
InParanoidiQ90469.
KOiK09295.
OMAiNPRGSAK.
OrthoDBiEOG091G0LON.
PhylomeDBiQ90469.
TreeFamiTF317819.

Miscellaneous databases

PROiQ90469.

Gene expression databases

BgeeiENSDARG00000057859.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXDAA_DANRE
AccessioniPrimary (citable) accession number: Q90469
Secondary accession number(s): A8E5N6
, O57371, P79730, P79731, Q6IQS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: October 5, 2010
Last modified: October 5, 2016
This is version 125 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.