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Q90435

- PO4F3_DANRE

UniProt

Q90435 - PO4F3_DANRE

Protein

POU domain, class 4, transcription factor 3

Gene

pou4f3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (24 Nov 2009)
      Previous versions | rss
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    Functioni

    May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi267 – 32660HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. brain development Source: ZFIN
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 4, transcription factor 3
    Alternative name(s):
    Brain-specific homeobox/POU domain protein 3.1
    Short name:
    Brain-3.1
    Short name:
    zfBrn-3.1
    Gene namesi
    Name:pou4f3
    Synonyms:brn-3.1, brn-3c, brn3.1, brn3c
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 9

    Organism-specific databases

    ZFINiZDB-GENE-990415-24. pou4f3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331POU domain, class 4, transcription factor 3PRO_0000100745Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in the nervous system. Expressed in the otic vesicle during embryogenesis. Expressed in the adult retina in a subset of retinal ganglion cells (RGCs), and at a lower level in the adult tectum. Not expressed in the adult olfactory bulb.3 Publications

    Developmental stagei

    Weakly expressed during embryogenesis, with stronger expression in the adult eye.2 Publications

    Gene expression databases

    BgeeiQ90435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ90435.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini172 – 24978POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi76 – 12449Ser-richAdd
    BLAST
    Compositional biasi99 – 16466His-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG289030.
    GeneTreeiENSGT00750000117482.
    HOGENOMiHOG000116305.
    HOVERGENiHBG053120.
    InParanoidiQ52NV5.
    KOiK09366.
    OrthoDBiEOG7RV9G7.
    PhylomeDBiQ90435.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90435-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMTMNGKQHF SMHPALHPSS EGMRRVCLPA PQLQGNIFSG FDESLLARAE    50
    ALAAADIVSH GKSHPFKTDV TYHTMSSVPC TSSSSTVPIS HPSSNLPSHH 100
    HHHLSHQTLE GDLLDHISSS LSVSGMGAPP DPSVMTTQAH QHHLQMGHLH 150
    QAMAMGHPHT LSVHNGMACV NDVESDPREL EAFAERFKQR RIKLGVTQAD 200
    VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPV LQAWLEEAEA 250
    AYREKNGKPD LFNGNERKRK RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI 300
    AEKLDLKKNV VRVWFCNQRQ KQKRMKYSAV H 331
    Length:331
    Mass (Da):36,550
    Last modified:November 24, 2009 - v2
    Checksum:i26E3487CCCC7533A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti299 – 2991A → R in AAB00435. (PubMed:8605028)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY995217 mRNA. Translation: AAX86839.1.
    U43658 Genomic DNA. Translation: AAB00435.1.
    RefSeqiNP_571353.1. NM_131278.1.
    UniGeneiDr.93311.

    Genome annotation databases

    EnsembliENSDART00000149175; ENSDARP00000124728; ENSDARG00000006206.
    GeneIDi30534.
    KEGGidre:30534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY995217 mRNA. Translation: AAX86839.1 .
    U43658 Genomic DNA. Translation: AAB00435.1 .
    RefSeqi NP_571353.1. NM_131278.1.
    UniGenei Dr.93311.

    3D structure databases

    ProteinModelPortali Q90435.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000149175 ; ENSDARP00000124728 ; ENSDARG00000006206 .
    GeneIDi 30534.
    KEGGi dre:30534.

    Organism-specific databases

    CTDi 5459.
    ZFINi ZDB-GENE-990415-24. pou4f3.

    Phylogenomic databases

    eggNOGi NOG289030.
    GeneTreei ENSGT00750000117482.
    HOGENOMi HOG000116305.
    HOVERGENi HBG053120.
    InParanoidi Q52NV5.
    KOi K09366.
    OrthoDBi EOG7RV9G7.
    PhylomeDBi Q90435.

    Miscellaneous databases

    NextBioi 20806916.
    PROi Q90435.

    Gene expression databases

    Bgeei Q90435.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection."
      Xiao T., Roeser T., Staub W., Baier H.
      Development 132:2955-2967(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Developmental expression of class III and IV POU domain genes in the zebrafish."
      Sampath K., Stuart G.W.
      Biochem. Biophys. Res. Commun. 219:565-571(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-311, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish."
      DeCarvalho A.C., Cappendijk S.L., Fadool J.M.
      Dev. Dyn. 229:869-876(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiPO4F3_DANRE
    AccessioniPrimary (citable) accession number: Q90435
    Secondary accession number(s): Q52NV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 24, 2009
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3