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Q90435 (PO4F3_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
POU domain, class 4, transcription factor 3
Alternative name(s):
Brain-specific homeobox/POU domain protein 3.1
Short name=Brain-3.1
Short name=zfBrn-3.1
Gene names
Name:pou4f3
Synonyms:brn-3.1, brn-3c, brn3.1, brn3c
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in specifying terminally differentiated neuronal phenotypes By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in the nervous system. Expressed in the otic vesicle during embryogenesis. Expressed in the adult retina in a subset of retinal ganglion cells (RGCs), and at a lower level in the adult tectum. Not expressed in the adult olfactory bulb. Ref.1 Ref.2 Ref.3

Developmental stage

Weakly expressed during embryogenesis, with stronger expression in the adult eye. Ref.2 Ref.3

Sequence similarities

Belongs to the POU transcription factor family. Class-4 subfamily.

Contains 1 homeobox DNA-binding domain.

Contains 1 POU-specific domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331POU domain, class 4, transcription factor 3
PRO_0000100745

Regions

Domain172 – 24978POU-specific
DNA binding267 – 32660Homeobox
Compositional bias76 – 12449Ser-rich
Compositional bias99 – 16466His-rich

Experimental info

Sequence conflict2991A → R in AAB00435. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q90435 [UniParc].

Last modified November 24, 2009. Version 2.
Checksum: 26E3487CCCC7533A

FASTA33136,550
        10         20         30         40         50         60 
MMTMNGKQHF SMHPALHPSS EGMRRVCLPA PQLQGNIFSG FDESLLARAE ALAAADIVSH 

        70         80         90        100        110        120 
GKSHPFKTDV TYHTMSSVPC TSSSSTVPIS HPSSNLPSHH HHHLSHQTLE GDLLDHISSS 

       130        140        150        160        170        180 
LSVSGMGAPP DPSVMTTQAH QHHLQMGHLH QAMAMGHPHT LSVHNGMACV NDVESDPREL 

       190        200        210        220        230        240 
EAFAERFKQR RIKLGVTQAD VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPV 

       250        260        270        280        290        300 
LQAWLEEAEA AYREKNGKPD LFNGNERKRK RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI 

       310        320        330 
AEKLDLKKNV VRVWFCNQRQ KQKRMKYSAV H 

« Hide

References

[1]"A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection."
Xiao T., Roeser T., Staub W., Baier H.
Development 132:2955-2967(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Developmental expression of class III and IV POU domain genes in the zebrafish."
Sampath K., Stuart G.W.
Biochem. Biophys. Res. Commun. 219:565-571(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-311, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]"Developmental expression of the POU domain transcription factor Brn-3b (Pou4f2) in the lateral line and visual system of zebrafish."
DeCarvalho A.C., Cappendijk S.L., Fadool J.M.
Dev. Dyn. 229:869-876(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY995217 mRNA. Translation: AAX86839.1.
U43658 Genomic DNA. Translation: AAB00435.1.
RefSeqNP_571353.1. NM_131278.1.
UniGeneDr.93311.

3D structure databases

ProteinModelPortalQ90435.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000149175; ENSDARP00000124728; ENSDARG00000006206.
GeneID30534.
KEGGdre:30534.

Organism-specific databases

CTD5459.
ZFINZDB-GENE-990415-24. pou4f3.

Phylogenomic databases

eggNOGNOG289030.
GeneTreeENSGT00750000117482.
HOGENOMHOG000116305.
HOVERGENHBG053120.
InParanoidQ52NV5.
KOK09366.
OrthoDBEOG7RV9G7.
PhylomeDBQ90435.

Gene expression databases

BgeeQ90435.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR000327. POU_specific.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]
PRINTSPR00028. POUDOMAIN.
SMARTSM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806916.
PROQ90435.

Entry information

Entry namePO4F3_DANRE
AccessionPrimary (citable) accession number: Q90435
Secondary accession number(s): Q52NV5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 24, 2009
Last modified: April 16, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families