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Protein

POU domain, class 4, transcription factor 3

Gene

pou4f3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi267 – 326HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
POU domain, class 4, transcription factor 3
Alternative name(s):
Brain-specific homeobox/POU domain protein 3.1
Short name:
Brain-3.1
Short name:
zfBrn-3.1
Gene namesi
Name:pou4f3
Synonyms:brn-3.1, brn-3c, brn3.1, brn3c
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-990415-24. pou4f3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001007451 – 331POU domain, class 4, transcription factor 3Add BLAST331

Proteomic databases

PaxDbiQ90435.

Expressioni

Tissue specificityi

Expressed in the nervous system. Expressed in the otic vesicle during embryogenesis. Expressed in the adult retina in a subset of retinal ganglion cells (RGCs), and at a lower level in the adult tectum. Not expressed in the adult olfactory bulb.3 Publications

Developmental stagei

Weakly expressed during embryogenesis, with stronger expression in the adult eye.2 Publications

Gene expression databases

BgeeiENSDARG00000006206.

Interactioni

Subunit structurei

Interaction with ISL1.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107974.

Structurei

3D structure databases

ProteinModelPortaliQ90435.
SMRiQ90435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini172 – 249POU-specificPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi76 – 124Ser-richAdd BLAST49
Compositional biasi99 – 164His-richAdd BLAST66

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG1168. Eukaryota.
ENOG410XPNX. LUCA.
GeneTreeiENSGT00760000118935.
HOGENOMiHOG000116305.
HOVERGENiHBG053120.
InParanoidiQ90435.
KOiK09366.
OMAiDVTYHTM.
OrthoDBiEOG091G0WBK.
PhylomeDBiQ90435.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
IPR013847. POU.
IPR032961. POU4F3.
IPR000327. POU_dom.
PANTHERiPTHR11636:SF104. PTHR11636:SF104. 1 hit.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
PRINTSiPR00028. POUDOMAIN.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90435-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTMNGKQHF SMHPALHPSS EGMRRVCLPA PQLQGNIFSG FDESLLARAE
60 70 80 90 100
ALAAADIVSH GKSHPFKTDV TYHTMSSVPC TSSSSTVPIS HPSSNLPSHH
110 120 130 140 150
HHHLSHQTLE GDLLDHISSS LSVSGMGAPP DPSVMTTQAH QHHLQMGHLH
160 170 180 190 200
QAMAMGHPHT LSVHNGMACV NDVESDPREL EAFAERFKQR RIKLGVTQAD
210 220 230 240 250
VGSALANLKI PGVGSLSQST ICRFESLTLS HNNMIALKPV LQAWLEEAEA
260 270 280 290 300
AYREKNGKPD LFNGNERKRK RTSIAAPEKR SLEAYFAIQP RPSSEKIAAI
310 320 330
AEKLDLKKNV VRVWFCNQRQ KQKRMKYSAV H
Length:331
Mass (Da):36,550
Last modified:November 24, 2009 - v2
Checksum:i26E3487CCCC7533A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299A → R in AAB00435 (PubMed:8605028).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY995217 mRNA. Translation: AAX86839.1.
U43658 Genomic DNA. Translation: AAB00435.1.
RefSeqiNP_571353.1. NM_131278.1.
UniGeneiDr.93311.

Genome annotation databases

EnsembliENSDART00000149175; ENSDARP00000124728; ENSDARG00000006206.
GeneIDi30534.
KEGGidre:30534.

Similar proteinsi

Entry informationi

Entry nameiPO4F3_DANRE
AccessioniPrimary (citable) accession number: Q90435
Secondary accession number(s): Q52NV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 24, 2009
Last modified: September 27, 2017
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families