Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Retinoic acid receptor RXR-gamma-A

Gene

rxrga

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi117 – 182Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri117 – 137NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri153 – 177NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-gamma-A
Alternative name(s):
Nuclear receptor subfamily 2 group B member 3-A
Retinoic acid receptor RXR-alpha
Retinoid X receptor alpha
Retinoid X receptor gamma-A
Gene namesi
Name:rxrga
Synonyms:nr2b1, nr2b3a, rxr, rxra, rxrg
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi

Organism-specific databases

ZFINiZDB-GENE-980526-36 rxrga

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535701 – 441Retinoic acid receptor RXR-gamma-AAdd BLAST441

Proteomic databases

PaxDbiQ90416

Expressioni

Tissue specificityi

Uniformly expressed from the blastula to mid-gastrula stages. In late gastrula stages, there is specific expression in the presumptive hindbrain and spinal cord. At 16 hours post-fertilization (hpf), expressed in the hindbrain from rhombomere 7/8 to the anterior spinal cord; this expression continues until 42 hpf. At 24 hpf, also expressed in the lateral plate mesoderm flanking rhombomere 6 and in the cranial neural crest, but not in the migrating crest. At 26 hpf, also expressed in retina. At 48 hpf, strong retinal expression.2 Publications

Developmental stagei

Expressed both maternally and zygotically.3 Publications

Interactioni

Subunit structurei

Homodimer (By similarity). Heterodimer; with a rar molecule (By similarity). Binds DNA preferentially as a rar/rxr heterodimer (By similarity). Heterodimerizes with rarga.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000021935

Structurei

3D structure databases

ProteinModelPortaliQ90416
SMRiQ90416
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 437NR LBDPROSITE-ProRule annotationAdd BLAST229

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 116ModulatingBy similarityAdd BLAST116
Regioni183 – 206HingeAdd BLAST24

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri117 – 137NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri153 – 177NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiQ90416
PhylomeDBiQ90416

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90416-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNNDTYLHL SSSLQVAHGH LSSPPSQPPL SSMVSHHHPS IINGLGSPYS
60 70 80 90 100
VITSSSLGSP SASMPTTSNM GYGALNSPQM NSLNSVSSSE DIKPPPGLAG
110 120 130 140 150
LGSYPCGSPG SLSKHICAIC GDRSSGKHYG VYSCEGCKGF FKRTIRKDLT
160 170 180 190 200
YTCRDNKDCQ IDKRQRNRCQ YCRYQKCLAM GMKREAVQEE RQRGRERSDN
210 220 230 240 250
EVDSSSSFNE EMPVEKILDA ELAVEPKTEA YMESSMSNST NDPVTNICQA
260 270 280 290 300
ADKQLFTLVE WAKRIPHFSD LPLDDQVILL RAGWNELLIA SFSHRSVTVK
310 320 330 340 350
DGILLATGLH VHRSSAHSAG VGSIFDRVLT ELVSKMRDMQ MDKTELGCLR
360 370 380 390 400
AIVLFNPDAK GLSNPSEVEA LREKVYASLE GYTKHNYPDQ PGRFAKLLLR
410 420 430 440
LPALRSIGLK CLEHLFFFKL IGDTPIDTFL MEMLEAPHQI T
Length:441
Mass (Da):48,720
Last modified:September 27, 2004 - v2
Checksum:iF169ADE221F2F13C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31S → G in AAC59720 (PubMed:7565671).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29940 mRNA Translation: AAC59720.1
BC059576 mRNA Translation: AAH59576.1
PIRiI50515
UniGeneiDr.348

Entry informationi

Entry nameiRXRGA_DANRE
AccessioniPrimary (citable) accession number: Q90416
Secondary accession number(s): Q6PBU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: September 27, 2004
Last modified: March 28, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health