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Protein

Retinoic acid receptor RXR-alpha-B

Gene

rxrab

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for this rxr is 9-cis retinoic acid (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi54 – 119Nuclear receptorPROSITE-ProRule annotationAdd BLAST66
Zinc fingeri54 – 74NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri90 – 114NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retinoic acid receptor RXR-alpha-B
Alternative name(s):
Nuclear receptor subfamily 2 group B member 1-B
Retinoid X receptor alpha-B
Gene namesi
Name:rxrab
Synonyms:nr2b1b, rxra, rxrg
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-243 rxrab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535791 – 379Retinoic acid receptor RXR-alpha-BAdd BLAST379

Proteomic databases

PaxDbiQ90415

Expressioni

Tissue specificityi

Uniform expression from the blastula to mid-gastrula stages. At 12 hours post-fertilization (hpf), expressed strongly in the tail and weakly elsewhere. At 24 hpf, weak expression in the forebrain, eyes and pharyngeal endoderm and continued expression in the tail mesoderm. At 48 hpf, anterior expression limited to ventral cells underlying the head, medial expression in the pectoral fin bud mesoderm and continued tail expression.2 Publications

Developmental stagei

Expressed both maternally and zygotically.4 Publications

Interactioni

Subunit structurei

Homodimer. Heterodimer; with a rar molecule. Binds DNA preferentially as a rar/rxr heterodimer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000004918

Structurei

3D structure databases

ProteinModelPortaliQ90415
SMRiQ90415
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 375NR LBDPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 53ModulatingBy similarityAdd BLAST53
Regioni120 – 141HingeBy similarityAdd BLAST22

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR2 subfamily.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri54 – 74NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri90 – 114NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260821
HOVERGENiHBG005606
InParanoidiQ90415
PhylomeDBiQ90415

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR021780 Nuc_recep-AF1
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000003 Retinoid-X_rcpt/HNF4
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF11825 Nuc_recep-AF1, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00545 RETINOIDXR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVPEQKQTV QLSSPMNAVS SSEDIKPPLG LNGVMKVPAH RIGTLSLSLT
60 70 80 90 100
KHICAICGDR SSGKHYGVYS CEGCKGFFKR TVRKDLTYTC RDNKDCMIDK
110 120 130 140 150
RQRNRCQYCR YQKCLAMGMK REAVQEERQR AKERSEAEFG GCANEDMPVE
160 170 180 190 200
KILEAELAVE PKTETYVEAN LSPSANSPND PVTNICQAAD KQLFTLVEWA
210 220 230 240 250
KRIPHFSDLP LDDQVILLRA GWNELLIASF SHRSIAVKDG ILLATGLHVH
260 270 280 290 300
RNSAHTAGVG AIFDRVLTEL VSKMRDMQMD KTELGCLRAI VLFNPDSKGL
310 320 330 340 350
SNPSEVEALR ERVYASLEAY CKHKYPDQPG RFAKLLLRLP ALRSIGLKCL
360 370
EHLFFFKLIG DTPIDTFLME MLEAPHQIT
Length:379
Mass (Da):42,556
Last modified:November 1, 1996 - v1
Checksum:i317EA9E9DE455D16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29894 mRNA Translation: AAC59719.1
PIRiI50514
RefSeqiNP_571228.1, NM_131153.1
UniGeneiDr.624

Genome annotation databases

GeneIDi793011
KEGGidre:793011

Similar proteinsi

Entry informationi

Entry nameiRXRAB_DANRE
AccessioniPrimary (citable) accession number: Q90415
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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