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Q903N5

- Q903N5_9HIV1

UniProt

Q903N5 - Q903N5_9HIV1

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Protein
Submitted name:

Protease

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aspartyl proteaseUniRule annotation, Hydrolase, Protease

Names & Taxonomyi

Protein namesi
Submitted name:
ProteaseImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2HB4X-ray2.15A1-99[»]
2PC0X-ray1.40A1-99[»]
ProteinModelPortaliQ903N5.

Family & Domainsi

Sequence similaritiesi

Contains peptidase A2 domain.SAAS annotations
Contains peptidase Adomain.SAAS annotations

Family and domain databases

Gene3Di2.40.70.10. 1 hit.
InterProiIPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PfamiPF00077. RVP. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q903N5-1 [UniParc]FASTAAdd to Basket

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PQITLWRRPL VTIKIGGQLK EALLDTGADD TVLEEMNLPG RWKPKMIGGI   50
GGFIKVRQYD QILIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNF 99
Length:99
Mass (Da):10,848
Last modified:December 1, 2001 - v1
Checksum:i374DA1342EB1500D
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei99 – 991Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY016860 Genomic DNA. Translation: AAK12468.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY016860 Genomic DNA. Translation: AAK12468.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2HB4 X-ray 2.15 A 1-99 [» ]
2PC0 X-ray 1.40 A 1-99 [» ]
ProteinModelPortali Q903N5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.40.70.10. 1 hit.
InterProi IPR001969. Aspartic_peptidase_AS.
IPR018061. Pept_A2A_retrovirus_sg.
IPR001995. Peptidase_A2_cat.
IPR021109. Peptidase_aspartic_dom.
[Graphical view ]
Pfami PF00077. RVP. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
PS00141. ASP_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification: a UNAIDS study."
    Delgado E., Leon-Ponte M., Villahermosa M.L., Cuevas M.T., Deibis L., Echeverria G., Thomson M.M., Perez-Alvarez L., Osmanov S., Najera R.
    AIDS Res. Hum. Retroviruses 17:753-758(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Conformational flexibility in the flap domains of ligand-free HIV protease."
    Heaslet H., Rosenfeld R., Giffin M., Lin Y.C., Tam K., Torbett B.E., Elder J.H., McRee D.E., Stout C.D.
    Acta Crystallogr. D 63:866-875(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).

Entry informationi

Entry nameiQ903N5_9HIV1
AccessioniPrimary (citable) accession number: Q903N5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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