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Q903N5

- Q903N5_9HIV1

UniProt

Q903N5 - Q903N5_9HIV1

Protein
Submitted name:

Protease

Gene
N/A
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. aspartic-type endopeptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aspartyl proteaseUniRule annotation, Hydrolase, Protease

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ProteaseImported
    OrganismiHuman immunodeficiency virus 1Imported
    Taxonomic identifieri11676 [NCBI]
    Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
    Virus hostiHomo sapiens (Human) [TaxID: 9606]

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2HB4X-ray2.15A1-99[»]
    2PC0X-ray1.40A1-99[»]
    ProteinModelPortaliQ903N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains peptidase A2 domain.SAAS annotation

    Family and domain databases

    Gene3Di2.40.70.10. 1 hit.
    InterProiIPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view]
    PfamiPF00077. RVP. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    PROSITEiPS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q903N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    PQITLWRRPL VTIKIGGQLK EALLDTGADD TVLEEMNLPG RWKPKMIGGI   50
    GGFIKVRQYD QILIEICGHK AIGTVLVGPT PVNIIGRNLL TQIGCTLNF 99
    Length:99
    Mass (Da):10,848
    Last modified:December 1, 2001 - v1
    Checksum:i374DA1342EB1500D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei99 – 991Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY016860 Genomic DNA. Translation: AAK12468.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY016860 Genomic DNA. Translation: AAK12468.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2HB4 X-ray 2.15 A 1-99 [» ]
    2PC0 X-ray 1.40 A 1-99 [» ]
    ProteinModelPortali Q903N5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.40.70.10. 1 hit.
    InterProi IPR001969. Aspartic_peptidase_AS.
    IPR018061. Pept_A2A_retrovirus_sg.
    IPR001995. Peptidase_A2_cat.
    IPR021109. Peptidase_aspartic_dom.
    [Graphical view ]
    Pfami PF00077. RVP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    PROSITEi PS50175. ASP_PROT_RETROV. 1 hit.
    PS00141. ASP_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of HIV type 1 protease and reverse transcriptase sequences from Venezuela for drug resistance-associated mutations and subtype classification: a UNAIDS study."
      Delgado E., Leon-Ponte M., Villahermosa M.L., Cuevas M.T., Deibis L., Echeverria G., Thomson M.M., Perez-Alvarez L., Osmanov S., Najera R.
      AIDS Res. Hum. Retroviruses 17:753-758(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Conformational flexibility in the flap domains of ligand-free HIV protease."
      Heaslet H., Rosenfeld R., Giffin M., Lin Y.C., Tam K., Torbett B.E., Elder J.H., McRee D.E., Stout C.D.
      Acta Crystallogr. D 63:866-875(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS).

    Entry informationi

    Entry nameiQ903N5_9HIV1
    AccessioniPrimary (citable) accession number: Q903N5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3