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Protein

Anosmin-1

Gene

ANOS1

Organism
Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be an adhesion-like molecule with anti-protease activity.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Keywords - Biological processi

Cell adhesion

Protein family/group databases

MEROPSiI17.004.

Names & Taxonomyi

Protein namesi
Recommended name:
Anosmin-1By similarity
Alternative name(s):
Kallmann syndrome protein homologBy similarity
Gene namesi
Name:ANOS1By similarity
Synonyms:KAL, KAL1
OrganismiCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 674653Anosmin-1PRO_0000041397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 71PROSITE-ProRule annotation
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Disulfide bondi80 ↔ 99PROSITE-ProRule annotation
Disulfide bondi84 ↔ 95PROSITE-ProRule annotation
Disulfide bondi110 ↔ 114PROSITE-ProRule annotation
Glycosylationi203 – 2031N-linked (GlcNAc...)Sequence analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence analysis
Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ90369.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini121 – 17050WAPPROSITE-ProRule annotationAdd
BLAST
Domaini180 – 281102Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini286 – 392107Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini418 – 51598Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini545 – 652108Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 WAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG006198.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
4.10.75.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00060. FN3. 3 hits.
SM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57256. SSF57256. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS51390. WAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90369-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRAPGASL ALLLWVTAVS CSPAGPGAAT ARRQDEAFST ARLTSRCLSL
60 70 80 90 100
QITRISAFFK HFQDNGSLAW CQNYKQCSKC LEPCKESWDL KRNHCQSFCE
110 120 130 140 150
PLFPKKNYEC LTSCEFLKYI LSVKQGDCPA PEKASGFAAA CFESCEADSE
160 170 180 190 200
CSGVKKCCSN GCGHTCQVPK NLYKGVPLKP RKELKFIELQ SGDLEVKWSS
210 220 230 240 250
KFNISIEPVI YVVQRRWNQG IHPSEDDATN WQTVAQTTDE RVQLSDIRAS
260 270 280 290 300
RWYQFRVAAV NVHGTRGFTA PSKHFRSSKD PSAPPAPSNI RIANISANND
310 320 330 340 350
GTVNVMITWD LPEEPDIPVH HYKVFWSWTY SKYVIPAKKK RRKITDGPQN
360 370 380 390 400
YVVLEGLQPN SNYNVELQAV TRWGQIRLKS AKVSLHFSTT QDNRNNNEQT
410 420 430 440 450
SVEKPPKGVV DPYPTFQRRK PTRFLKIGTP FYQDNQLQVK IYWKKSGINM
460 470 480 490 500
NQFQVHSLLE SCTHNDTKGL EKVTELTYEN YMILKDLSFS CKYKVTVLPA
510 520 530 540 550
KSKSRFKAES IFFVTPPCST FKEKTHKHIN CAAEEVPVLP KVLAKPENLS
560 570 580 590 600
ASFIVQEGNI TGHFSWKISK AVLHQPMTGF QVTWAEVTTE SRQNSLPNSI
610 620 630 640 650
ISQSQILPAD HYVLTVPNLR PSMLYRLEVQ VLTTGGEGPA TIKLFRTPDL
660 670
PPFLPHRPHL KHHPHRYKPP PEKY
Length:674
Mass (Da):76,439
Last modified:November 1, 1996 - v1
Checksum:i52ACDB45C75C0392
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13976 mRNA. Translation: AAA88500.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13976 mRNA. Translation: AAA88500.1.

3D structure databases

ProteinModelPortaliQ90369.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI17.004.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006198.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
4.10.75.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR008197. WAP_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00095. WAP. 1 hit.
[Graphical view]
PRINTSiPR00003. 4DISULPHCORE.
SMARTiSM00060. FN3. 3 hits.
SM00217. WAP. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF57256. SSF57256. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
PS51390. WAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the chicken and quail homologues of the human gene responsible for the X-linked Kallmann syndrome."
    Legouis R., Cohen-Salmon M., del Castillo I., Levilliers J., Capy L., Mornon J.-P., Petit C.
    Genomics 17:516-518(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKALM_COTJA
AccessioniPrimary (citable) accession number: Q90369
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1996
Last modified: September 16, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.