Q90352 (AVT_CATCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: [Arg8]-vasotocin receptor Short name=AVT
Organism	Catostomus commersonii (White sucker)
Taxonomic identifier	7971 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cobitoidea › Catostomidae › Catostomus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Binds to vasotocin. Produces an induction of membrane chloride currents indicating that it is coupled to the inositol phosphate/calcium pathway.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in pituitary, liver, gills, swim bladder and lateral line.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	[Arg8]-vasotocin receptor		PRO_0000069178
Regions
	Topological domain	1 – 27	27	Extracellular Potential
	Transmembrane	28 – 48	21	Helical; Name=1; Potential
	Topological domain	49 – 67	19	Cytoplasmic Potential
	Transmembrane	68 – 88	21	Helical; Name=2; Potential
	Topological domain	89 – 98	10	Extracellular Potential
	Transmembrane	99 – 119	21	Helical; Name=3; Potential
	Topological domain	120 – 141	22	Cytoplasmic Potential
	Transmembrane	142 – 162	21	Helical; Name=4; Potential
	Topological domain	163 – 191	29	Extracellular Potential
	Transmembrane	192 – 212	21	Helical; Name=5; Potential
	Topological domain	213 – 257	45	Cytoplasmic Potential
	Transmembrane	258 – 278	21	Helical; Name=6; Potential
	Topological domain	279 – 295	17	Extracellular Potential
	Transmembrane	296 – 316	21	Helical; Name=7; Potential
	Topological domain	317 – 434	118	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Glycosylation	12	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 176		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90352 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 2C2A4A49EE1C2BA5	FASTA	434	49,498
	10 20 30 40 50 60 MGRIANQTTA SNDTDPFGRN EEVAKMEITV LSVTFFVAVI GNLSVLLAMH NTKKKSSRMH 70 80 90 100 110 120 LFIKHLSLAD MVVAFFQVLP QLCWEITFRF YGPDFLCRIV KHLQVLGMFA STYMMVMMTL 130 140 150 160 170 180 DRYIAICHPL KTLQQPTQRA YIMIGSTWLC SLLLSTPQYF IFSLSEIQNG SYVYDCWGHF 190 200 210 220 230 240 IEPWGIRAYI TWITVGIFLI PVIILMICYG FICHSIWKNI KCKTMRGTRN TKDGMIGKVS 250 260 270 280 290 300 VSSVTIISRA KLRTVKMTLV IVLAYIVCWA PFFIVQMWSV WDENFSWDDS ENAAVTLSAL 310 320 330 340 350 360 LASLNSCCNP WIYMLFSGHL LYDFLRCFPC CKKPRNMLQK EDSDSSIRRN TLLTKLAAGR 370 380 390 400 410 420 MTNDGFGSWR DPCNSRKSSQ SIGLDCFCKS SQCLEHDCSR KSSQCIPLDC SRKSSQCIPL 430 DCSRKSSQCM SKES

References

[1]

"Structure, function, and phylogeny of [Arg8]vasotocin receptors from teleost fish and toad." Mahlmann S., Meyerhof W., Hausmann H., Heierhorst J., Schoenrock C., Zwiers H., Lederis K., Richter D. Proc. Natl. Acad. Sci. U.S.A. 91:1342-1345(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X76321 mRNA. Translation: CAA53958.1.
PIR	I50132.
3D structure databases
ProteinModelPortal	Q90352.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG105710.
Family and domain databases
InterPro	IPR015076. DUF1856. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001817. Vasoprsn_rcpt. IPR001224. Vprs_V1A_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF08983. DUF1856. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00752. VASOPRSNV1AR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AVT_CATCO

Accession

Primary (citable) accession number: Q90352

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program