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Protein

[Arg8]-vasotocin receptor

Gene
N/A
Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to vasotocin. Produces an induction of membrane chloride currents indicating that it is coupled to the inositol phosphate/calcium pathway.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
[Arg8]-vasotocin receptor
Short name:
AVT
OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
Taxonomic identifieri7971 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 67CytoplasmicSequence analysisAdd BLAST19
Transmembranei68 – 88Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini89 – 98ExtracellularSequence analysis10
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 141CytoplasmicSequence analysisAdd BLAST22
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 191ExtracellularSequence analysisAdd BLAST29
Transmembranei192 – 212Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini213 – 257CytoplasmicSequence analysisAdd BLAST45
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 295ExtracellularSequence analysisAdd BLAST17
Transmembranei296 – 316Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini317 – 434CytoplasmicSequence analysisAdd BLAST118

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000691781 – 434[Arg8]-vasotocin receptorAdd BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi12N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in pituitary, liver, gills, swim bladder and lateral line.

Structurei

3D structure databases

ProteinModelPortaliQ90352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

CDDicd15385. 7tmA_V1aR. 1 hit.
InterProiView protein in InterPro
IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiView protein in SMART
SM01164. DUF1856. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q90352-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRIANQTTA SNDTDPFGRN EEVAKMEITV LSVTFFVAVI GNLSVLLAMH
60 70 80 90 100
NTKKKSSRMH LFIKHLSLAD MVVAFFQVLP QLCWEITFRF YGPDFLCRIV
110 120 130 140 150
KHLQVLGMFA STYMMVMMTL DRYIAICHPL KTLQQPTQRA YIMIGSTWLC
160 170 180 190 200
SLLLSTPQYF IFSLSEIQNG SYVYDCWGHF IEPWGIRAYI TWITVGIFLI
210 220 230 240 250
PVIILMICYG FICHSIWKNI KCKTMRGTRN TKDGMIGKVS VSSVTIISRA
260 270 280 290 300
KLRTVKMTLV IVLAYIVCWA PFFIVQMWSV WDENFSWDDS ENAAVTLSAL
310 320 330 340 350
LASLNSCCNP WIYMLFSGHL LYDFLRCFPC CKKPRNMLQK EDSDSSIRRN
360 370 380 390 400
TLLTKLAAGR MTNDGFGSWR DPCNSRKSSQ SIGLDCFCKS SQCLEHDCSR
410 420 430
KSSQCIPLDC SRKSSQCIPL DCSRKSSQCM SKES
Length:434
Mass (Da):49,498
Last modified:November 1, 1996 - v1
Checksum:i2C2A4A49EE1C2BA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76321 mRNA. Translation: CAA53958.1.
PIRiI50132.

Similar proteinsi

Entry informationi

Entry nameiAVT_CATCO
AccessioniPrimary (citable) accession number: Q90352
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families