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Q90346 (HXB1_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B1
Gene names
Name:hoxb1
OrganismCyprinus carpio (Common carp)
Taxonomic identifier7962 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family. Labial subfamily.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence CAA62553.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Homeobox protein Hox-B1
PRO_0000200112

Regions

DNA binding221 – 28060Homeobox
Motif197 – 2026Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
Q90346 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 96274EC6D4213322

FASTA31534,781
        10         20         30         40         50         60 
MDNSSMNSFL EYTICNRGTN AYSPKAGYQH LDQALSGPFH TGHARYSHNA DGRLYIGGSN 

        70         80         90        100        110        120 
QPAAAQHQHQ SGVYAHHQHQ THQSGIGLTY GGTGTTSYGT QACANPDYAQ HQYFINPEQD 

       130        140        150        160        170        180 
GMYYHSSGFS NSNLGPHYGS MAGAYCGAQG AVPAAPYQHH GCEGQDHQRG YSQGTYADLS 

       190        200        210        220        230        240 
RSQGRERDTD QSPPGKTFDW MKVKRNPPKT AKVADYGLGP QNTIRTNFTT KQLTELEKEF 

       250        260        270        280        290        300 
HFSKYLTRAR RVEIAATLEL NETQVKIWFQ NRRMKQKKRE KEGLAPASST LSKDLEDHSD 

       310 
HSTSTSPGAS PSPDS 

« Hide

References

[1]"Expression of Hoxb-1 during gastrulation and segmentation stages of carp (Cyprinus carpio)."
Stevens C.J.M., Samallo J., Schipper H., Stroband H.W.J., Te Kronnie G.
Int. J. Dev. Biol. 40:463-470(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91079 mRNA. Translation: CAA62554.1.
X91079 mRNA. Translation: CAA62553.1. Different initiation.

3D structure databases

ProteinModelPortalQ90346.
SMRQ90346. Positions 195-282.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006089.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHXB1_CYPCA
AccessionPrimary (citable) accession number: Q90346
Secondary accession number(s): Q90345
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries