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Q90346

- HXB1_CYPCA

UniProt

Q90346 - HXB1_CYPCA

Protein

Homeobox protein Hox-B1

Gene

hoxb1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi221 – 28060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B1
    Gene namesi
    Name:hoxb1
    OrganismiCyprinus carpio (Common carp)
    Taxonomic identifieri7962 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Homeobox protein Hox-B1PRO_0000200112Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ90346.
    SMRiQ90346. Positions 195-282.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi197 – 2026Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG006089.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90346-1 [UniParc]FASTAAdd to Basket

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    MDNSSMNSFL EYTICNRGTN AYSPKAGYQH LDQALSGPFH TGHARYSHNA    50
    DGRLYIGGSN QPAAAQHQHQ SGVYAHHQHQ THQSGIGLTY GGTGTTSYGT 100
    QACANPDYAQ HQYFINPEQD GMYYHSSGFS NSNLGPHYGS MAGAYCGAQG 150
    AVPAAPYQHH GCEGQDHQRG YSQGTYADLS RSQGRERDTD QSPPGKTFDW 200
    MKVKRNPPKT AKVADYGLGP QNTIRTNFTT KQLTELEKEF HFSKYLTRAR 250
    RVEIAATLEL NETQVKIWFQ NRRMKQKKRE KEGLAPASST LSKDLEDHSD 300
    HSTSTSPGAS PSPDS 315
    Length:315
    Mass (Da):34,781
    Last modified:November 1, 1997 - v1
    Checksum:i96274EC6D4213322
    GO

    Sequence cautioni

    The sequence CAA62553.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91079 mRNA. Translation: CAA62554.1.
    X91079 mRNA. Translation: CAA62553.1. Different initiation.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91079 mRNA. Translation: CAA62554.1 .
    X91079 mRNA. Translation: CAA62553.1 . Different initiation.

    3D structure databases

    ProteinModelPortali Q90346.
    SMRi Q90346. Positions 195-282.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006089.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of Hoxb-1 during gastrulation and segmentation stages of carp (Cyprinus carpio)."
      Stevens C.J.M., Samallo J., Schipper H., Stroband H.W.J., Te Kronnie G.
      Int. J. Dev. Biol. 40:463-470(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHXB1_CYPCA
    AccessioniPrimary (citable) accession number: Q90346
    Secondary accession number(s): Q90345
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3