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Protein

Homeobox protein Hox-B1

Gene

hoxb1

Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi221 – 28060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Gene namesi
Name:hoxb1
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Homeobox protein Hox-B1PRO_0000200112Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ90346.
SMRiQ90346. Positions 195-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi197 – 2026Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG006089.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90346-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSSMNSFL EYTICNRGTN AYSPKAGYQH LDQALSGPFH TGHARYSHNA
60 70 80 90 100
DGRLYIGGSN QPAAAQHQHQ SGVYAHHQHQ THQSGIGLTY GGTGTTSYGT
110 120 130 140 150
QACANPDYAQ HQYFINPEQD GMYYHSSGFS NSNLGPHYGS MAGAYCGAQG
160 170 180 190 200
AVPAAPYQHH GCEGQDHQRG YSQGTYADLS RSQGRERDTD QSPPGKTFDW
210 220 230 240 250
MKVKRNPPKT AKVADYGLGP QNTIRTNFTT KQLTELEKEF HFSKYLTRAR
260 270 280 290 300
RVEIAATLEL NETQVKIWFQ NRRMKQKKRE KEGLAPASST LSKDLEDHSD
310
HSTSTSPGAS PSPDS
Length:315
Mass (Da):34,781
Last modified:November 1, 1997 - v1
Checksum:i96274EC6D4213322
GO

Sequence cautioni

The sequence CAA62553.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91079 mRNA. Translation: CAA62554.1.
X91079 mRNA. Translation: CAA62553.1. Different initiation.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91079 mRNA. Translation: CAA62554.1.
X91079 mRNA. Translation: CAA62553.1. Different initiation.

3D structure databases

ProteinModelPortaliQ90346.
SMRiQ90346. Positions 195-282.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006089.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of Hoxb-1 during gastrulation and segmentation stages of carp (Cyprinus carpio)."
    Stevens C.J.M., Samallo J., Schipper H., Stroband H.W.J., Te Kronnie G.
    Int. J. Dev. Biol. 40:463-470(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXB1_CYPCA
AccessioniPrimary (citable) accession number: Q90346
Secondary accession number(s): Q90345
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 27, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.