Reviewed, UniProtKB/Swiss-Prot Q90344 (EPHB2_COTJA)

Names and origin

Protein names

Recommended name:
    Ephrin type-B receptor 2
    EC=2.7.10.1
Alternative name(s):
    Tyrosine-protein kinase receptor QEK5

Gene names

Name:	EPHB2
Synonyms:	QEK5

Organism

Coturnix coturnix japonica (Japanese quail)

Taxonomic identifier

93934 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	987 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor for members of the ephrin-B family.
Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. Contains 2 fibronectin type-III domains. Contains 1 protein kinase domain. Contains 1 SAM (sterile alpha motif) domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Repeat Signal Transmembrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Receptor Transferase Tyrosine-protein kinase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ephrin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 987	968	Ephrin type-B receptor 2		PRO_0000016830
Regions
	Topological domain	20 – 544	525	Extracellular Potential
	Transmembrane	545 – 565	21	Potential
	Topological domain	566 – 987	422	Cytoplasmic Potential
	Domain	326 – 427	102	Fibronectin type-III 1
	Domain	433 – 528	96	Fibronectin type-III 2
	Domain	622 – 885	264	Protein kinase
	Domain	914 – 978	65	SAM
	Nucleotide binding	628 – 636	9	ATP By similarity
	Motif	985 – 987	3	PDZ-binding Potential
	Compositional bias	185 – 322	138	Cys-rich
Sites
	Active site	747	1	Proton acceptor By similarity
	Binding site	654	1	ATP By similarity
Amino acid modifications
	Glycosylation	266	1	N-linked (GlcNAc...) Potential
	Glycosylation	337	1	N-linked (GlcNAc...) Potential
	Glycosylation	429	1	N-linked (GlcNAc...) Potential
	Glycosylation	478	1	N-linked (GlcNAc...) Potential
	Glycosylation	483	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q90344-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 05D6ECC68B718DD7	FASTA	987	110,331
	10 20 30 40 50 60 MGPLWFCCLP LALLPLLAAV EETLMDSTTA TAELGWMVHP PSGWEEVSGY DENMNTIRTY 70 80 90 100 110 120 QVCNVFESSQ NNWLRTKYIR RRGAHRIHVE MKFSVRDCSS IPNVPGSCKE TFNLYYYESD 130 140 150 160 170 180 FDSATKTFPN WMENPWMKVD TIAADERFSQ VDLGGRVMKI NTEVRSFGPV SKNGFYLAFQ 190 200 210 220 230 240 DYWGCMSLIA VRVFYRKCPR VIQNGADFQE TLSGAESTSL VASRGTCINK AEEVDVPIKQ 250 260 270 280 290 300 HCNGDGEWLV PIGRCMCRPG YESVANGTVC RGCPSGTFKA SQGDEGCVHC PINSRTTSEG 310 320 330 340 350 360 ATNCVCRNGY YRADADPVDM PCTTIPSAPQ SVISSVNETS LMLEWTPPRD SGGREDLVYN 370 380 390 400 410 420 IICKSCGSGR GACTRCGDNV QFAPRQLGLT EPRIYISDLL AHTQYTFEIQ AVNGVTDQSP 430 440 450 460 470 480 FSPQFASVNI TTNQAAPSAV SIMHQVSRTV DSITLSWSQP DQPNGVILDY ELQYYEKNLS 490 500 510 520 530 540 ELNSTAVKSP TNTVTVQNLK AGTIYVFQVR ARTVAGYGRY SGKMYFQTMT EAEYQTSVQE 550 560 570 580 590 600 KLPLIIGSSA AGLVFLIAVV VIIIVCNRRG FERADSEYTD KLQHYTSGHM TPGMKIYIDP 610 620 630 640 650 660 FTYEDPNEAV REFAKEIDIS CVKIEQVIGA GEFGEVCSGH LKLPGKREIF VAIKTLKSGY 670 680 690 700 710 720 TEKQRRDFLS EASIMGQFDH PNVIHLEGVV TKSSPVMIIT EFMENGSLDS FLRQNDGQFT 730 740 750 760 770 780 VIQLVGMLRG IAAGMKYLAD MNYVHRDLAA RNTLVNSNLV CKVSDFGLSR FLEDDTSDPT 790 800 810 820 830 840 YTSALGGKIP IRWTAPEAIQ YRKFTSASDV WSYGIVMWEV MSYGERPYWD MTNQDVINAI 850 860 870 880 890 900 EQDYRLPPPM DCPNALHQLM LDCWQKDRNH RPKFGQIVNT LDKMIRNPNS LKAMAPLSSG 910 920 930 940 950 960 VNLPLLDRTI PDYTSFNTVD EWLDAIKMSQ YKESYASAGF TTFDIVSQMT VEDILRVGVT 970 980 LAGHQKKILN SIQVMRAQMN QIQSVEV

References

[1]	"The receptor tyrosine kinase QEK5 mRNA is expressed in a gradient within the neural retina and the tectum." Kenny D., Bronner-Fraser M., Marcelle C. Dev. Biol. 172:708-716(1995) [PubMed: 8612986] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X91737 mRNA. Translation: CAA62862.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPA based on UniProtKB P54763.
SMR	Q90344. Positions 20-200, 595-893, 911-986.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q90344.
Enzyme and pathway databases
BRENDA	2.7.10.1. 142881.
Family and domain databases
InterPro	IPR013032. EGF-like_reg_CS. IPR001090. Ephrin_rcpt_lig-bd. IPR008957. Fibronectin_typ-III-like_fold. IPR003961. FN_III. IPR003962. FnIII_subd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR001660. SAM. IPR011510. SAM_2. IPR013761. SAM_type. IPR001245. Tyr_pkinase. IPR008266. Tyr_pkinase_AS. IPR016257. TyrPK_ephrin_receptor. IPR001426. YKase_receptorV_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.30. FN_III-like. 2 hits. G3DSA:1.10.150.50. SAM_type. 1 hit.
Pfam	PF01404. Ephrin_lbd. 1 hit. PF00041. fn3. 2 hits. PF07714. Pkinase_Tyr. 1 hit. PF07647. SAM_2. 1 hit. [Graphical view]
PIRSF	PIRSF000666. TyrPK_ephrin_receptor. 1 hit.
PRINTS	PR00014. FNTYPEIII. PR00109. TYRKINASE.
ProDom	PD001495. Ephrin_receptor. 1 hit. PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00615. EPH_lbd. 1 hit. SM00060. FN3. 2 hits. SM00454. SAM. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
PROSITE	PS01186. EGF_2. 1 hit. Uncertain. PS50853. FN3. 2 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. False negative. PS00790. RECEPTOR_TYR_KIN_V_1. 1 hit. PS00791. RECEPTOR_TYR_KIN_V_2. 1 hit. PS50105. SAM_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EPHB2_COTJA

Accession

Primary (citable) accession number: Q90344

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	October 13, 2009
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)