Q90343 (NR13_COTJA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anti-apoptotic protein NR13

Alternative name(s):
Apoptosis regulator Nr-13

Gene names

Name:

NR13

Organism

Coturnix coturnix japonica (Japanese quail) (Coturnix japonica)

Taxonomic identifier

93934 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Perdicinae › Coturnix

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Shows anti-apoptotic properties. Counteract the pro-apoptotic activity of BAX. Ref.1
Subunit structure	Interacts with BAX By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Mainly expressed in neural and muscular tissues. Ref.1
Developmental stage	Expression is dramatically down-regulated after embryonic day 7 in the optic tectum, and correlates with the onset of apoptosis in this area. Ref.1
Induction	By Rous sarcoma virus. Ref.1
Sequence similarities	Belongs to the Bcl-2 family.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of apoptotic process Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 177	177	Anti-apoptotic protein NR13		PRO_0000143071
Regions
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	156 – 176	21	Helical; Potential
	Motif	75 – 94	20	BH1
	Motif	126 – 141	16	BH2

Sequences

	Sequence		Length	Mass (Da)
	Q90343 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: AD5CE79D3353CC1F	FASTA	177	18,826
	10 20 30 40 50 60 MPGSLKEETA LLLEDYFQHR AGGAALPPSA TAAELRRAAA ELERRERPFF RSCAPLARAE 70 80 90 100 110 120 PREAAALLRK VAAQLETDGG LNWGRLLALV VFAGTLAAAL AESACEEGPS RLAAALTAYL 130 140 150 160 170 AEEQGEWMEE HGGWDGFCRF FGRHGSQPAD QNSTLSNAIM AAAGFGIAGL AFLLVVR

References

[1]

"A Bcl-2-related gene is activated in avian cells transformed by the Rous sarcoma virus." Gillet G., Guerin M., Trembleau A., Brun G. EMBO J. 14:1372-1381(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION. Tissue: Fibroblast and Neuroretina.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X84418 Genomic DNA. Translation: CAA59136.1.
3D structure databases
ProteinModelPortal	Q90343.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006528.
Family and domain databases
InterPro	IPR002475. Bcl2-like. IPR020717. Bcl2_BH1_motif_CS. IPR020726. Bcl2_BH2_motif_CS. IPR026298. Blc2_fam. IPR026313. NR13. [Graphical view]
PANTHER	PTHR11256. PTHR11256. 1 hit. PTHR11256:SF7. PTHR11256:SF7. 1 hit.
Pfam	PF00452. Bcl-2. 1 hit. [Graphical view]
PRINTS	PR01862. BCL2FAMILY.
PROSITE	PS50062. BCL2_FAMILY. 1 hit. PS01080. BH1. 1 hit. PS01258. BH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NR13_COTJA

Accession

Primary (citable) accession number: Q90343

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program