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Protein

Myosin heavy chain, fast skeletal muscle

Gene
N/A
Organism
Cyprinus carpio (Common carp)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1858ATPSequence analysis

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin heavy chain, fast skeletal muscle
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19351935Myosin heavy chain, fast skeletal musclePRO_0000123435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei129 – 1291N6,N6,N6-trimethyllysineSequence analysis

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiQ90339.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Structurei

3D structure databases

ProteinModelPortaliQ90339.
SMRiQ90339. Positions 839-964.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 779695Myosin motorAdd
BLAST
Domaini782 – 81130IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni659 – 68123Actin-bindingAdd
BLAST
Regioni761 – 77515Actin-bindingAdd
BLAST
Regioni812 – 83928HingeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili840 – 19351096Sequence analysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG004704.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90339-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDGEMECFG PAAVYLRKTE RERIEAQNTP FDAKTAFFVV DPDEMYLKGT
60 70 80 90 100
LVSKEGGKAT VKTHSGKTVT VKEDEIFPMN PPKFDKIEDM AMMTHLNEPA
110 120 130 140 150
VLFNLKERYA AWMIYTYSGL FCVTVNPYKW LPVYDAVVVG GYRGKKRIEA
160 170 180 190 200
PPHIFSISDN AYQFMLTDRE NQSVLITGES GAGKTVNTKR VIQYFATVGA
210 220 230 240 250
MSGPKKPEPV PGKMQGSLED QIVAANPLLE AYGNAKTVRN DNSSRFGKFI
260 270 280 290 300
RIHFGTTGKL ASADIETYLL EKSRVTFQLS AERSYHIFYQ LMTGHKPELL
310 320 330 340 350
EALLITTNPY DYPMISQGEI TVKSINDVEE FIATDTAIDI LGFTADEKIS
360 370 380 390 400
IYKLTGAVMH HGNMKFKQKQ REEQAEPDGT EVADKIAYLM GLNSADMLKA
410 420 430 440 450
LCFPRVKVGN EMVTKGQTVP QVNNAVSALS KSVYEKMFLW MVIRINEMLD
460 470 480 490 500
TKQPRQFFIG VLDIAGFEIF DFNSLEQLCI NFTNEKLQQF FNHHMFVLEQ
510 520 530 540 550
EEYKKEGIEW EFIDFGMDLA ACIELIEKPM GIFSILEEEC MFPKATDTSF
560 570 580 590 600
KNKLHDQHLG KTAAFQKPKP AKGKAEAHFS LVHYAGTVDY NIVGWLDKNK
610 620 630 640 650
DPLNDSVVQL YQKSSLKVLA FLYATHGAEA EGGGGKKGKK KGGSFQTVSA
660 670 680 690 700
LFRENLGKLM TNLRSTHPHF VRCLIPNESK TPGLMENYLV IHQLRCNGVL
710 720 730 740 750
EGIRICRKGF PSRILYGDFK QRYKVLNASV IPEGQFIDNK KASEKLLGSI
760 770 780 790 800
DVDHTQYKFG HTKVFFKAGL LGALEEMRDE KLALLVTMTQ ALCRGYVMRK
810 820 830 840 850
EFVKMMERRE SIYSIQYNIR SFMNVKHWPW MKLYFKIKPL LKSAETEKEM
860 870 880 890 900
AAMKENYEKM KEDLTKALAK KKELEEKMVS LLQEKNDLQL QVTAESENLS
910 920 930 940 950
DAEERCEGLI KSKIQLEAKL KETNERLEDE EEINAELTAK KRKLEDECSE
960 970 980 990 1000
LKKDIDDLEL TLAKVEKEKH ATENKVKNLT EEMASQDESI AKLTKEKKAL
1010 1020 1030 1040 1050
QEAHQQTLDD LQAEEDKVNT LTKAKTKLEQ QVDDLEGSLE QEKKLRMDLE
1060 1070 1080 1090 1100
RAKRKLEGDL KLAQESIMDL ENEKQQSDEK IKKKDFEISQ LLSKIEDEQS
1110 1120 1130 1140 1150
LGAQLQKKIK ELQARIEELE EEIEAERAAR AKVEKQRADL SRELEEISER
1160 1170 1180 1190 1200
LEEAGGATAA QIEMNKKREA EFQKMRRDLE ESTLQHEATA AALRKEQADS
1210 1220 1230 1240 1250
VAELGEQIDN LQRVKQKLEK EKSEYKMEID DLTSNMEAVA KAKANLEKMC
1260 1270 1280 1290 1300
RTLEDQLSEI KTKSDENVRQ LNDMNAQRAR LQTENGEFSR QLEEKEALVS
1310 1320 1330 1340 1350
QLTRGKQAYT QQIEELKRHI EEEVKAKNAL AHAVQSARHD CDLLREQYEE
1360 1370 1380 1390 1400
EQEAKAELQR GMSKANSEVA QWRTKYETDA IQRTEELEEA KKKLAQRLQD
1410 1420 1430 1440 1450
AEESIEAVNS KCASLEKTKQ RLQGEVEDLM IDVERANSLA ANLDKKQRNF
1460 1470 1480 1490 1500
DKVLAEWKQK YEESQAELEG AQKEARSLST ELFKMKNSYE EALDHLETLK
1510 1520 1530 1540 1550
RENKNLQQEI SDLTEQLGET GKSIHELEKA KKTVESEKSE IQTALEEAEG
1560 1570 1580 1590 1600
TLEHEESKIL RVQLELNQVK SEIDRKLAEK DEEMEQIKRN SQRVIDSMQS
1610 1620 1630 1640 1650
TLDSEVRSRN DALRVKKKME GDLNEMEIQL SHANRQAAEA QKQLRNVQGQ
1660 1670 1680 1690 1700
LKDAQLHLDE AVRGQEDMKE QVAMVERRNS LMQAEIEELR AALEQTERGR
1710 1720 1730 1740 1750
KVAEQELVDA SERVGLLHSQ NTSLINTKKK LEADLVQVQG EVDDAVQEAR
1760 1770 1780 1790 1800
NAEEKAKKAI TDAAMMAEEL KKEQDTSAHL ERMKKNLEVT VKDLQHRLDE
1810 1820 1830 1840 1850
AESLAMKGGK KQLQKLESRV RELEAEVEAE QRRGADAVKG VRKYERRVKE
1860 1870 1880 1890 1900
LTYQTEEDKK NVIRLQDLVD KLQLKVKVYK RQAEEAEEQT NTHLSRYRKV
1910 1920 1930
QHELEEAQER ADVAESQVNK LRAKSRDAGK SKDEE
Length:1,935
Mass (Da):221,601
Last modified:January 1, 1998 - v2
Checksum:i9A1244B67D63C83B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89992 mRNA. Translation: BAA22069.1.
D50476 mRNA. Translation: BAA09069.1.
D43700 mRNA. Translation: BAA07802.1.
PIRiI50496.
S66521.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89992 mRNA. Translation: BAA22069.1.
D50476 mRNA. Translation: BAA09069.1.
D43700 mRNA. Translation: BAA07802.1.
PIRiI50496.
S66521.

3D structure databases

ProteinModelPortaliQ90339.
SMRiQ90339. Positions 839-964.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ90339.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004704.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYSS_CYPCA
AccessioniPrimary (citable) accession number: Q90339
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.