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Protein

Isotocin receptor

Gene
N/A
Organism
Catostomus commersonii (White sucker) (Cyprinus commersonnii)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to isotocin. Can also be activated by vasotocin, mesotocin, oxytocin and Arg-vasopressin, although these have lower potencies than isotocin. Produces an induction of membrane chloride currents indicating that it is coupled to the inositol phosphate/calcium pathway.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Isotocin receptor
Short name:
ITR
OrganismiCatostomus commersonii (White sucker) (Cyprinus commersonnii)
Taxonomic identifieri7971 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCatostomidaeCatostomus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 6921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini70 – 8617CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini108 – 12417ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini146 – 16015CytoplasmicSequence analysisAdd
BLAST
Transmembranei161 – 18121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini182 – 20625ExtracellularSequence analysisAdd
BLAST
Transmembranei207 – 22721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini228 – 27649CytoplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini298 – 31114ExtracellularSequence analysisAdd
BLAST
Transmembranei312 – 33221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini333 – 39058CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Isotocin receptorPRO_0000069694Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi30 – 301N-linked (GlcNAc...)Sequence analysis
Disulfide bondi116 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed in brain, intestine, bladder, skeletal muscle, lateral line, gills and kidney.

Structurei

3D structure databases

ProteinModelPortaliQ90334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMFKEQDF WSFNESSRNS TVGNETFGGN QTVNPLKRNE EVAKVEVTVL
60 70 80 90 100
ALVLFLALAG NLCVLIAIYT AKHTQSRMYY LMKHLSIADL VVAVFQVLPQ
110 120 130 140 150
LIWDITFRFY GPDFLCRLVK YLQTVGMFAS TYMLVLMSID RCIAICQPLR
160 170 180 190 200
SLHKRKDRCY VIVSWALSLV FSVPQVYIFS LREIGNGVYD CWGDFVQPWG
210 220 230 240 250
AKAYITWISL TIYIIPVAIL GGCYGLISFK IWQNFKRKTK KDQCITLTTA
260 270 280 290 300
ASKANALARV SSVKLVSKAK ITTVKMTFVI VLAYIVCWTP FFFVQMWSAW
310 320 330 340 350
DPEAPREAMP FIISMLLASL NSCCNPWIYM FFAGHLFHDL KQSLLCCSTL
360 370 380 390
YLKSSQCRCD QEHDSRKSNC STYVIKSTSS QRSITQSSIT
Length:390
Mass (Da):44,504
Last modified:November 1, 1996 - v1
Checksum:i2C3E9BA244FD6913
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87783 mRNA. Translation: CAA61050.1.
PIRiS66497.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87783 mRNA. Translation: CAA61050.1.
PIRiS66497.

3D structure databases

ProteinModelPortaliQ90334.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITR_CATCO
AccessioniPrimary (citable) accession number: Q90334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.