SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q90327

- MK08A_CYPCA

UniProt

Q90327 - MK08A_CYPCA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Mitogen-activated protein kinase 8A
Gene
mapk8a
Organism
Cyprinus carpio (Common carp)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.By similarity

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei55 – 551ATP By similarityBy similarity
Active sitei151 – 1511Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 386ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 1195.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 8A (EC:2.7.11.24)
Short name:
MAP kinase 8A
Short name:
MAPK 8A
Alternative name(s):
Stress-activated protein kinase JNKa
c-Jun N-terminal kinase A
Gene namesi
Name:mapk8a
OrganismiCyprinus carpio (Common carp)
Taxonomic identifieri7962 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCyprinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Mitogen-activated protein kinase 8A
PRO_0000186266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei183 – 1831Phosphothreonine By similarityBy similarity
Modified residuei185 – 1851Phosphotyrosine By similarityBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ90327.

Expressioni

Tissue specificityi

Expressed in brain and ovary.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90327.
SMRiQ90327. Positions 10-364.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 321296Protein kinaseBy similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi183 – 1853TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG014652.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01772. JNKMAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90327-1 [UniParc]FASTAAdd to Basket

« Hide

MNKNKREKEF YSVDVGDSTF TVLKRYQNLR PIGSGAQGIV CSAYDHNLER    50
NVAIKKLSRP FQNQTHAKRA YRELVLMKYV NHKNIICLLN VFTSQKTLDE 100
FQDVYLVMEL MDANLCQVIQ MELDHERLSY LLYQMLCGIK HLHSAGIIHR 150
DLKPSNIVVK SDCTLKILDF GLARTAATGL LMTPYVVTRY YRAPEVILGM 200
GYQANVDIWS VGCILAEMVR HKILFPGRDY IDQWNKVIEQ LGTPTQEFMM 250
KLNQSVRTYV ENRPRYTGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVEEALQHPY INVWYDPAEV EAPPPVITDK QLDEREHTVE 350
EWKELIYKEV LDWEERMKNG AIRGQPSPLG AAVINGSPQP SSSSSINDVS 400
SMSTEPTVAS DTDSSLEASA GPLSCCR 427
Length:427
Mass (Da):48,606
Last modified:November 1, 1996 - v1
Checksum:i518B490DD048120C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83273 mRNA. Translation: BAA11880.1.
PIRiJC5693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83273 mRNA. Translation: BAA11880.1 .
PIRi JC5693.

3D structure databases

ProteinModelPortali Q90327.
SMRi Q90327. Positions 10-364.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q90327.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG014652.

Enzyme and pathway databases

BRENDAi 2.7.11.24. 1195.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01772. JNKMAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK."
    Hashimoto H., Matsuo Y., Yokoyama Y., Toyohara H., Sakaguchi M.
    J. Biochem. 122:381-386(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Ovary.

Entry informationi

Entry nameiMK08A_CYPCA
AccessioniPrimary (citable) accession number: Q90327
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 13, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi