Q90322 (BDNF_CYPCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-derived neurotrophic factor
Short name=BDNF

Gene names

Name:

bdnf

Organism

Cyprinus carpio (Common carp)

Taxonomic identifier

7962 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Cyprinus

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the NGF-beta family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Growth factor
PTM	Cleavage on pair of basic residues Disulfide bond Glycoprotein
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Propeptide	19 – 151	133	By similarity		PRO_0000019651
	Chain	152 – 270	119	Brain-derived neurotrophic factor		PRO_0000019652
Amino acid modifications
	Glycosylation	144	1	N-linked (GlcNAc...) Potential
	Disulfide bond	164 ↔ 231		By similarity
	Disulfide bond	209 ↔ 260		By similarity
	Disulfide bond	219 ↔ 262		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90322 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 049DE1ECE4742EAA	FASTA	270	29,572
	10 20 30 40 50 60 MTILFVTMVI SYFSCMRAAP MREIPGVQGG HRAEGYLGAA AAAAAAITSG SRGHGTPQSG 70 80 90 100 110 120 GGLPWLTDTF EQVIEELLEV EGEATQQLGP GADQGQGGGG PAAMADSKDV DMYASRVMIS 130 140 150 160 170 180 NQVPLEPPLL FLLEEYKNYL DAANMSMRVR RHSDPARRGE LSVCDSISQW VTALDKKTAI 190 200 210 220 230 240 DMSGQTVTVL EKVPVTNGQL KQYFYETKCN PLGYTKEGCR GIDKRHYNSQ CRTTQSYVRA 250 260 270 LTMDSKRKIG WRFIRIDTSC VCTLTIKRGR

References

[1]	Liu T.S., Chang G.D., Huang F.L., Lo T.B. Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L27171 Genomic DNA. Translation: AAA49204.1.
3D structure databases
ProteinModelPortal	Q90322.
SMR	Q90322. Positions 159-267.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG006494.
Family and domain databases
InterPro	IPR020430. Brain-der_neurotrophic_factor. IPR020408. Nerve_growth_factor-like. IPR002072. Nerve_growth_factor-rel. IPR019846. Nerve_growth_factor_CS. [Graphical view]
PANTHER	PTHR11589. PTHR11589. 1 hit.
Pfam	PF00243. NGF. 1 hit. [Graphical view]
PIRSF	PIRSF001789. NGF. 1 hit.
PRINTS	PR01912. BDNFACTOR. PR00268. NGF.
ProDom	PD002052. Nerve_growth_factor-rel. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00140. NGF. 1 hit. [Graphical view]
PROSITE	PS00248. NGF_1. 1 hit. PS50270. NGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDNF_CYPCA

Accession

Primary (citable) accession number: Q90322

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	October 3, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program