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Protein

Cadherin-2

Gene

cdh2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone. N-cadherin may be involved in neuronal recognition mechanism. Controls neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain.1 Publication

GO - Molecular functioni

GO - Biological processi

  • adherens junction organization Source: ZFIN
  • auditory receptor cell stereocilium organization Source: ZFIN
  • axial mesoderm structural organization Source: ZFIN
  • axonal fasciculation Source: ZFIN
  • axon guidance Source: ZFIN
  • brain development Source: ZFIN
  • cardioblast differentiation Source: ZFIN
  • cartilage condensation Source: ZFIN
  • cell-cell adhesion Source: ZFIN
  • cell-cell adhesion mediated by cadherin Source: UniProtKB
  • cell migration in hindbrain Source: ZFIN
  • cell migration involved in somitogenic axis elongation Source: ZFIN
  • cell morphogenesis Source: ZFIN
  • cilium assembly Source: ZFIN
  • commissural neuron axon guidance Source: ZFIN
  • dorsal convergence Source: ZFIN
  • dorsal fin morphogenesis Source: ZFIN
  • ectoderm development Source: ZFIN
  • embryonic eye morphogenesis Source: ZFIN
  • embryonic pectoral fin morphogenesis Source: ZFIN
  • embryonic retina morphogenesis in camera-type eye Source: ZFIN
  • establishment of epithelial cell apical/basal polarity Source: ZFIN
  • generation of neurons Source: ZFIN
  • glial cell differentiation Source: UniProtKB
  • hindbrain development Source: ZFIN
  • hindbrain structural organization Source: ZFIN
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • mesoderm morphogenesis Source: ZFIN
  • midbrain development Source: ZFIN
  • motor neuron axon guidance Source: ZFIN
  • motor neuron migration Source: ZFIN
  • negative regulation of neural precursor cell proliferation Source: ZFIN
  • neural crest cell migration Source: ZFIN
  • neural tube development Source: ZFIN
  • neuronal stem cell population maintenance Source: UniProtKB
  • neuron cell-cell adhesion Source: ZFIN
  • neuron migration Source: ZFIN
  • odontogenesis Source: ZFIN
  • peripheral nervous system development Source: ZFIN
  • pigment cell development Source: ZFIN
  • post-anal tail morphogenesis Source: ZFIN
  • regulation of eye photoreceptor cell development Source: ZFIN
  • regulation of signal transduction Source: InterPro
  • retina development in camera-type eye Source: ZFIN
  • semicircular canal morphogenesis Source: ZFIN
  • sensory epithelium regeneration Source: ZFIN
  • somitogenesis Source: ZFIN
  • spinal cord patterning Source: ZFIN
  • synapse assembly Source: ZFIN
  • tissue regeneration Source: ZFIN
  • ventricular system development Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cell adhesion, Differentiation, Neurogenesis

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-2
Alternative name(s):
Neural cadherin
Short name:
N-cadherin
ZNCAD
Gene namesi
Name:cdh2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-990415-171. cdh2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini147 – 711565ExtracellularSequence analysisAdd
BLAST
Transmembranei712 – 73221HelicalSequence analysisAdd
BLAST
Topological domaini733 – 893161CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • catenin complex Source: ZFIN
  • integral component of membrane Source: UniProtKB-KW
  • intercalated disc Source: UniProtKB
  • perinuclear region of cytoplasm Source: ZFIN
  • plasma membrane Source: ZFIN
  • presynaptic membrane Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 146122Sequence analysisPRO_0000003739Add
BLAST
Chaini147 – 893747Cadherin-2PRO_0000003740Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence analysis
Glycosylationi389 – 3891N-linked (GlcNAc...)Sequence analysis
Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence analysis
Glycosylationi559 – 5591N-linked (GlcNAc...)Sequence analysis
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence analysis
Glycosylationi638 – 6381N-linked (GlcNAc...)Sequence analysis
Glycosylationi679 – 6791N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiQ90275.
PRIDEiQ90275.

Expressioni

Tissue specificityi

Expression in the embryo is initially found in all deep cells but later becomes restricted to various epithelial and neuronal tissues. Found in discrete areas of cell-cell adhesion when epiboly is nearly completed. Expressed in adult brain, eyes and trunk.1 Publication

Developmental stagei

Expression is first detected in the embryo during gastrulation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003949.

Structurei

3D structure databases

ProteinModelPortaliQ90275.
SMRiQ90275. Positions 147-361, 823-888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini148 – 254107Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini255 – 369115Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini370 – 484115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini485 – 590106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini591 – 702112Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi850 – 86516Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiQ90275.
KOiK06736.
PhylomeDBiQ90275.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR030051. CDH2.
[Graphical view]
PANTHERiPTHR24027:SF79. PTHR24027:SF79. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90275-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYPSGGVMLG LLAALQVAVQ GTGAMPCQPG FTENEYNVMT ADVITEGQVL
60 70 80 90 100
LKVDFVDCGR GSGLRFESGD PADFRIDADG TVMAARTLQL TDRKGQSLEI
110 120 130 140 150
KAKDENSQEQ WMVHINFTQP KQVPVILFPR HSVLVKGDDS VNRVKRDWVI
160 170 180 190 200
PPVNVLENSR KQFPEELVKI QSDKDKSNTL RYSVTGPGAD QNPTGLFIID
210 220 230 240 250
PISGLLSVTK PLDREHIPNF HLRAHAVDIN GNQMENPIDI IINVIDMNDN
260 270 280 290 300
RPEFTHQIWN GTVDEGAKPG TFVMTVTSQD KDDPNTANGM LRYKILSQTP
310 320 330 340 350
ESPSSNMFTI NNKTGKIITV AAGLDREKVP QYTLIIQATD MEGNPTYGLS
360 370 380 390 400
NTATAVIRLL DVNDNAPEFT RETFHGEVPE NRVNVIVTNL TVTDKDEPGT
410 420 430 440 450
PAWNAVYRII SGDPTGRFSI PTDPVTNEGL VTVVKPVDFE MNRSFMLTVV
460 470 480 490 500
ADNEVPLASG IHRTRQSTAT VSIRVIDVNE SPNFDPNPKQ IKLEEGLPQW
510 520 530 540 550
SMLTTFTAHD PDRYMQQTIS YSKLYDPANW LEIDPNNGRI STIAVLDRES
560 570 580 590 600
PYVKNNLYNA TFMASDNGVP RASGTGTLQI YLLDINDNAP RVFPQEAEVC
610 620 630 640 650
ERPEPNAINI TAVDGDLNPN AGPYAFELPN RPSDIRRNWT LTRISGDHAQ
660 670 680 690 700
LSLKISYLES GIYELPISIT DSGNLPMSNT TYLRIKVCQC DHHGDCVDME
710 720 730 740 750
RIMAAGLGTG AIIAILICII ILLVLVLMFV MWMKRRDKER QAKQLLIDPE
760 770 780 790 800
DDVRDNILKY DEEGGGEEDQ DYDLSQLQQP DTLEPDMIKP VGIRRLDERP
810 820 830 840 850
MHSEPNYPIR SAAPHPGDIG EFIHEGLKAA DTDPTAPPYD SLLVFDYEGS
860 870 880 890
GSTAGSLSSL HSSSSGGDQD YDYLNDWGPR FRKLADMYGG NDD
Length:893
Mass (Da):98,990
Last modified:November 25, 2002 - v2
Checksum:i5E3FF0CDD92B3A6F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti510 – 5101D → DD in CAA47890 (PubMed:7873785).Curated
Sequence conflicti530 – 5301W → L in CAA47890 (PubMed:7873785).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF430842 mRNA. Translation: AAN61915.1.
AF418565 mRNA. Translation: AAL59160.1.
X67648 mRNA. Translation: CAA47890.1.
RefSeqiNP_571156.2. NM_131081.2.
UniGeneiDr.75081.

Genome annotation databases

GeneIDi30291.
KEGGidre:30291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF430842 mRNA. Translation: AAN61915.1.
AF418565 mRNA. Translation: AAL59160.1.
X67648 mRNA. Translation: CAA47890.1.
RefSeqiNP_571156.2. NM_131081.2.
UniGeneiDr.75081.

3D structure databases

ProteinModelPortaliQ90275.
SMRiQ90275. Positions 147-361, 823-888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003949.

Proteomic databases

PaxDbiQ90275.
PRIDEiQ90275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30291.
KEGGidre:30291.

Organism-specific databases

CTDi1000.
ZFINiZDB-GENE-990415-171. cdh2.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiQ90275.
KOiK06736.
PhylomeDBiQ90275.

Miscellaneous databases

PROiQ90275.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
IPR030051. CDH2.
[Graphical view]
PANTHERiPTHR24027:SF79. PTHR24027:SF79. 1 hit.
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH2_DANRE
AccessioniPrimary (citable) accession number: Q90275
Secondary accession number(s): Q8UVQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: July 6, 2016
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.