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Protein

Paired box protein Pax-2a

Gene

pax2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • sequence-specific DNA binding Source: ZFIN

GO - Biological processi

  • anterior/posterior pattern specification Source: ZFIN
  • anterior/posterior pattern specification involved in pronephros development Source: ZFIN
  • cell fate specification Source: ZFIN
  • cerebellum development Source: ZFIN
  • cerebellum formation Source: ZFIN
  • cilium assembly Source: ZFIN
  • embryonic camera-type eye morphogenesis Source: ZFIN
  • embryonic pattern specification Source: ZFIN
  • hindbrain development Source: ZFIN
  • inner ear receptor cell differentiation Source: ZFIN
  • kidney development Source: ZFIN
  • locus ceruleus development Source: ZFIN
  • midbrain development Source: ZFIN
  • midbrain-hindbrain boundary development Source: ZFIN
  • nervous system development Source: UniProtKB
  • otic placode formation Source: ZFIN
  • peripheral nervous system development Source: ZFIN
  • pronephric glomerulus morphogenesis Source: ZFIN
  • pronephros development Source: ZFIN
  • pronephros morphogenesis Source: ZFIN
  • thyroid gland development Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
  • vestibular receptor cell development Source: ZFIN

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2a
Alternative name(s):
No isthmus protein
Pax[Zf-b]
Gene namesi
Name:pax2a
Synonyms:noi, pax2.1, paxzf-b
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 13

Organism-specific databases

ZFINiZDB-GENE-990415-8 pax2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501771 – 410Paired box protein Pax-2aAdd BLAST410

Proteomic databases

PaxDbiQ90268

Expressioni

Tissue specificityi

Expressed during embryogenesis in the kidney, optic stalk, midbrain, otic vesicle and a row of cells along the spinal cord and the hindbrain.

Developmental stagei

First seen during the formation of neural keel. At 9-10 hours of development expression seen in two laterally located transverse stripes of cells in the rostral 1/3 of the embryo, and the two areas subsequently move towards the midline and form the posterior portion of the midbrain. Detected in the otic placode, Wolffian duct including the nephritic primordium and optic stalk at 10-12 hours. At 14-15 hours expression seen in the single cells along the spinal cord, presumably interneurons.

Gene expression databases

BgeeiENSDARG00000028148
ExpressionAtlasiQ90268 baseline

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071460

Structurei

3D structure databases

ProteinModelPortaliQ90268
SMRiQ90268
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 145PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

eggNOGiKOG3862 Eukaryota
ENOG410ZT0S LUCA
GeneTreeiENSGT00680000099553
HOVERGENiHBG009115
InParanoidiQ90268
KOiK15608
PhylomeDBiQ90268
TreeFamiTF315397

Family and domain databases

CDDicd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001523 Paired_dom
IPR022130 Pax2_C
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00292 PAX, 1 hit
PF12403 Pax2_C, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequences (12)i

Sequence statusi: Complete.

This entry describes 12 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform 4 (identifier: Q90268-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDIHCKADPF SAMHLSHIGH GGVNQLGGVF VNGRPLPDVV RQRIVELAHQ
60 70 80 90 100
GVRPCDISRQ LRVSHGCVSK ILGRYYETGS IKPGVIGGSK PKVATPKVVE
110 120 130 140 150
KIAEYKRQNP TMFAWEIRDR LLAEGVCDND TVPSVSSINR IIRTKVQQPF
160 170 180 190 200
HPSSDGTGTP LSTAGHTIVP STASPPVSSA SNDPVGSYSI NGILGIPRSN
210 220 230 240 250
GEKRKRDDVL WSGNHLDGRK IGYHGSDGSG PNSDSQGSVE SLRKHLRADA
260 270 280 290 300
FTQQQLEALD RVFERPSYPD VFPTSEHIKP EQANEYSLPA LNPGLDEVKP
310 320 330 340 350
SLSTSVSSDL GSSVSQSYPV VTGREMASTT LPGYPPHVPP TGQGSYPTST
360 370 380 390 400
LAGMVPGSDF SGNPYSHPQY TTYNEAWRFS NPALLSSPYY YSAASRGSGP
410
PTAATAYDRH
Length:410
Mass (Da):44,099
Last modified:May 27, 2002 - v2
Checksum:i6BE302826C516FD7
GO
Isoform 1 (identifier: Q90268-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R

Show »
Length:406
Mass (Da):43,748
Checksum:i5FA7AE607B8459AA
GO
Isoform 2 (identifier: Q90268-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D

Show »
Length:391
Mass (Da):42,029
Checksum:i945AA4986AE92EDB
GO
Isoform 3 (identifier: Q90268-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     323-334: GREMASTTLPGY → DKSAGSTVPAGH
     335-410: Missing.

Show »
Length:334
Mass (Da):35,851
Checksum:i2BBDAFFEFD23FADA
GO
Isoform 5 (identifier: Q90268-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D
     283-322: Missing.

Show »
Length:351
Mass (Da):37,950
Checksum:i8832D34E75D5F0E0
GO
Isoform 6 (identifier: Q90268-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-322: Missing.

Show »
Length:292
Mass (Da):31,410
Checksum:i3D86C3147EEBD30A
GO
Isoform 7 (identifier: Q90268-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     323-334: GREMASTTLPGY → DKSAGSTVPAGH
     335-410: Missing.

Show »
Length:330
Mass (Da):35,500
Checksum:i122C55AA129118F8
GO
Isoform 8 (identifier: Q90268-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:404
Mass (Da):43,377
Checksum:i6EDC36E73C32675F
GO
Isoform 9 (identifier: Q90268-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-224: VLWSGNHLDGRKIGYH → D
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:389
Mass (Da):41,658
Checksum:i37B68840DF11B472
GO
Isoform 10 (identifier: Q90268-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     209-224: VLWSGNHLDGRKIGYH → D
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:385
Mass (Da):41,306
Checksum:i2FD08B99DB3FD5DF
GO
Isoform 11 (identifier: Q90268-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-19: LSHIG → R
     386-410: SSPYYYSAASRGSGPPTAATAYDRH → MPHPGAPGLPLLPLPMTAT

Show »
Length:400
Mass (Da):43,025
Checksum:iC8A1151F0D5C4610
GO
Isoform 12 (identifier: Q90268-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-224: VLWSGNHLDGRKIGYH → D

Show »
Length:395
Mass (Da):42,380
Checksum:i9629926611BDC6BD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti74 – 79Missing in allele TM243A; no midbrain/hindbrain boundary. 6
Natural varianti79G → V in allele TY31A; no midbrain/hindbrain boundary. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00234815 – 19LSHIG → R in isoform 1, isoform 2, isoform 5, isoform 6, isoform 7, isoform 10 and isoform 11. 2 Publications5
Alternative sequenceiVSP_002350209 – 322Missing in isoform 6. CuratedAdd BLAST114
Alternative sequenceiVSP_002349209 – 224VLWSG…KIGYH → D in isoform 2, isoform 5, isoform 9, isoform 10 and isoform 12. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_002351283 – 322Missing in isoform 5. CuratedAdd BLAST40
Alternative sequenceiVSP_002352323 – 334GREMA…TLPGY → DKSAGSTVPAGH in isoform 3 and isoform 7. CuratedAdd BLAST12
Alternative sequenceiVSP_002353335 – 410Missing in isoform 3 and isoform 7. CuratedAdd BLAST76
Alternative sequenceiVSP_002354386 – 410SSPYY…AYDRH → MPHPGAPGLPLLPLPMTAT in isoform 8, isoform 9, isoform 10 and isoform 11. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63961 mRNA Translation: CAA45378.1
AF067530 mRNA Translation: AAD19285.1
AF067531 mRNA Translation: AAD19286.1
AF067532 mRNA Translation: AAD19287.1
AF067533 mRNA Translation: AAD19288.1
AF067534 mRNA Translation: AAD19289.1
AF067535 mRNA Translation: AAD19290.1
AF067536 mRNA Translation: AAD19291.1
AF067537 mRNA Translation: AAD19292.1
AF067538 mRNA Translation: AAD19293.1
AF067539 mRNA Translation: AAD19294.1
AF067540 mRNA Translation: AAD19295.1
AF067541 mRNA Translation: AAD19296.1
BC066690 mRNA Translation: AAH66690.1
PIRiS23341
RefSeqiNP_571259.1, NM_131184.2 [Q90268-3]
UniGeneiDr.75076

Genome annotation databases

EnsembliENSDART00000076998; ENSDARP00000071466; ENSDARG00000028148 [Q90268-3]
ENSDART00000134424; ENSDARP00000121417; ENSDARG00000028148 [Q90268-6]
GeneIDi30425
KEGGidre:30425

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAX2A_DANRE
AccessioniPrimary (citable) accession number: Q90268
Secondary accession number(s): Q9PWK8
, Q9PWK9, Q9PWL0, Q9PWL1, Q9YGU5, Q9YGU6, Q9YGU7, Q9YGU8, Q9YGU9, Q9YGV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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