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Protein

Mesotocin receptor

Gene
N/A
Organism
Rhinella marina (Cane toad) (Bufo marinus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds to mesotocin and may play a role in the regulation of water and salt transport.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mesotocin receptor
Short name:
MTR
OrganismiRhinella marina (Cane toad) (Bufo marinus)
Taxonomic identifieri8386 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeRhinella

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5050ExtracellularSequence analysisAdd
BLAST
Transmembranei51 – 7121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini72 – 8716CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini109 – 11911ExtracellularSequence analysisAdd
BLAST
Transmembranei120 – 14021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini141 – 15919CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20727ExtracellularSequence analysisAdd
BLAST
Transmembranei208 – 22821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini229 – 27547CytoplasmicSequence analysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini297 – 30812ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 32921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini330 – 38960CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Mesotocin receptorPRO_0000069882Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence analysis
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Glycosylationi31 – 311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi117 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highly expressed in the bladder. Also expressed in kidney, brain and skeletal muscle.

Structurei

3D structure databases

ProteinModelPortaliQ90252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90252-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLCLNLDC SELPNSSWVN SSMENQNHSS NSTRDPLKRN EEVAKVEVTV
60 70 80 90 100
LALILFLALA GNICVLLGIY INRHKHSRMY FFMKHLSIAD LVVAIFQVLP
110 120 130 140 150
QLIWDITFRF YAPDLVCRLV TYLQVVGMFA STYMLLLMSL DRCLAICQPL
160 170 180 190 200
RSLHRRSDCV YVLFTWILSF LLSTPQTVIF SLTEVGNGVY DCRADFIQPW
210 220 230 240 250
GPKAYITWIT LAVYIIPVMI LSVCYGLISY KIWQNIRLKT VCESNLRLST
260 270 280 290 300
SRRATLSRVS SVRLISKAKI RTVKMTFIIV LAYIVCWTPF FFVQMWSVWD
310 320 330 340 350
PNPPKEASLF IIAMLLGSLN SCCNPWIYML FTGHLFHDLL QSFLCCSARY
360 370 380
LKTQQQGSDL SASRKSNSST FVLSRKSSSQ KSITQPSTA
Length:389
Mass (Da):44,384
Last modified:November 1, 1996 - v1
Checksum:iD24EBF372EBB6B38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93313 mRNA. Translation: CAA63713.1.
PIRiS71336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93313 mRNA. Translation: CAA63713.1.
PIRiS71336.

3D structure databases

ProteinModelPortaliQ90252.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG105710.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002062. Oxytocn_rcpt.
IPR001817. Vasoprsn_rcpt.
[Graphical view]
PANTHERiPTHR24241:SF19. PTHR24241:SF19. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00665. OXYTOCINR.
PR00896. VASOPRESSINR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTR_RHIMB
AccessioniPrimary (citable) accession number: Q90252
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.