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Protein

Zinc metalloproteinase/disintegrin

Gene
N/A
Organism
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Snake venom metalloproteinase: impairs hemostasis in the envenomed animal.By similarity
Disintegrin halystatin: inhibits platelet aggregation and bone resorption.1 Publication

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi333Zinc; catalyticBy similarity1
Active sitei334PROSITE-ProRule annotation1
Metal bindingi337Zinc; catalyticBy similarity1
Metal bindingi343Zinc; catalyticBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Cell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Platelet aggregation inhibiting toxin, Protease, Toxin

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM12.134.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase/disintegrin
Cleaved into the following 2 chains:
Alternative name(s):
Disintegrin adinbitor
Disintegrin brevicaudin-1b
OrganismiGloydius halys (Chinese water mocassin) (Agkistrodon halys)
Taxonomic identifieri8714 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeGloydius

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000042445021 – 190By similarityAdd BLAST170
ChainiPRO_5000139751191 – 407Snake venom metalloproteinaseAdd BLAST217
ChainiPRO_5000139752408 – 480Disintegrin halystatinAdd BLAST73

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi279N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi308 ↔ 386By similarity
Disulfide bondi348 ↔ 370By similarity
Disulfide bondi350 ↔ 353By similarity
Disulfide bondi413 ↔ 428By similarity
Disulfide bondi415 ↔ 423By similarity
Disulfide bondi422 ↔ 445By similarity
Disulfide bondi436 ↔ 442By similarity
Disulfide bondi441 ↔ 466By similarity
Disulfide bondi454 ↔ 473By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ90220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini197 – 391Peptidase M12BPROSITE-ProRule annotationAdd BLAST195
Domaini399 – 480DisintegrinPROSITE-ProRule annotationAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi458 – 460Cell attachment site3

Sequence similaritiesi

Contains 1 disintegrin domain.PROSITE-ProRule annotation
Contains 1 peptidase M12B domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90220-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQVLLITIC LAVFPFQGSS IVLDSGNLNE FEVVYPEKVT ALPRAAVKNK
60 70 80 90 100
YEDAMQYEFK VNGEPLLLHL ERNKGLFSDD YSEIHYSPDA REISAYPSVE
110 120 130 140 150
DHCFYHGRVE NDADSTASLS ACDGLKAHFK IQGEMYLIEP LEVSDTDAHA
160 170 180 190 200
VFKYENVEKE DEPPKMCGVT QNWESYESTK KASQLNVSPD QQRFPQRFIK
210 220 230 240 250
LAIYVDHGMY TKYAGNSERI TKRVHQMINN INMMCRALNI VTSLSVLRIW
260 270 280 290 300
SEKDLITVNA SAPSSLTLFG AWRETVLLNR TSHDHAQLMT ATIFNGNVIG
310 320 330 340 350
RAPVGGMCDP KRSVAIVRDH NAILFIVAVT MTHEMGHNLG MHHDEDKCNC
360 370 380 390 400
NTCIMSKVLS RQPSYEFSDC NENEYQTYVT DHSPQCILND PLRPDTVSTP
410 420 430 440 450
VSGNELLEAG EECDCGSPGN PCCDAATCKL RQGAQCAEGL CCDQCRFMKK
460 470 480
GTVCRIARGD DMDDYCNGIS AGCPRNPFHA
Length:480
Mass (Da):53,620
Last modified:November 1, 1996 - v1
Checksum:i5CF5E6476511B3D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28870 mRNA. Translation: BAA06025.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28870 mRNA. Translation: BAA06025.1.

3D structure databases

ProteinModelPortaliQ90220.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM12.134.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006978.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
4.10.70.10. 1 hit.
InterProiIPR018358. Disintegrin_CS.
IPR001762. Disintegrin_dom.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR002870. Peptidase_M12B_N.
[Graphical view]
PfamiPF00200. Disintegrin. 1 hit.
PF01562. Pep_M12B_propep. 1 hit.
PF01421. Reprolysin. 1 hit.
[Graphical view]
PRINTSiPR00289. DISINTEGRIN.
SMARTiSM00050. DISIN. 1 hit.
[Graphical view]
SUPFAMiSSF57552. SSF57552. 1 hit.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS00427. DISINTEGRIN_1. 1 hit.
PS50214. DISINTEGRIN_2. 1 hit.
PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVM2H1_GLOHA
AccessioniPrimary (citable) accession number: Q90220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2013
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Miscellaneous

The disintegrin belongs to the medium disintegrin subfamily.

Caution

The disintegrin is also encoded by another precursor (AC Q1PBD1).Curated

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.