Q90185 (NS1_AADNV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Non-structural protein NS1

Alternative name(s):
Non-capsid protein NS-1
Short name=NCVP1

Gene names

Name:

NS1

Organism

Aedes albopictus densovirus (isolate Boublik/1994) (AalDNV)

Taxonomic identifier

648330 [NCBI]

Taxonomic lineage

Viruses › ssDNA viruses › Parvoviridae › Densovirinae › Brevidensovirus

Virus host

Aedes albopictus (Asian tiger mosquito) (Culex albopictus) [TaxID: 7160]

Protein attributes

Sequence length	805 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Seems necessary for viral DNA replication, plays an important role in the regulation of capsid gene expression. It is covalently bound to the 5'-termini of viral DNA, and can influence DNA packaging. NS1 is also believed to possess the topoisomerase I type nicking activity, and cytotoxic activity By similarity.
Sequence similarities	Belongs to the parvoviruses non-capsid protein family. Contains 1 SF3 helicase domain.

Ontologies

Keywords
Biological process	DNA replication
Ligand	ATP-binding Nucleotide-binding
PTM	Covalent protein-DNA linkage
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW viral genome replication Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 805	805	Non-structural protein NS1		PRO_0000222477
Regions
	Domain	553 – 708	156	SF3 helicase
	Nucleotide binding	583 – 590	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q90185 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 36408B471CD476F4	FASTA	805	92,645
	10 20 30 40 50 60 STEYIRGINE GRVSSMESVC SEHSPCEHGN IECECIFCWE HDAQCKSRRR ELDLGEPTGS 70 80 90 100 110 120 ERGMANNYEQ SRNEDLYCTE TVPSSAALQA NTITERDIRE DFTDQTVDNI YPQLHSGSRA 130 140 150 160 170 180 SEQLEFAFPT IGTRSWEILI RQSYEHLKPD YKEEDFQSHI RRVRRQLFPE KTMDNNGSQA 190 200 210 220 230 240 STTQMLRDDI ERCGIESIAD SASEDNGDGV DGTCISTVDI QGNCIVNAHG NEQATGSKTR 250 260 270 280 290 300 KIRATTTPES SESKKHKGSN NQQNIQEQSS TTAIADGHDI VDGELDGRSE SNRETAYYTF 310 320 330 340 350 360 VLHKNNCKED WRYIATTRAK QAPSFITFDH GDHIHILFSS SNTGGNSTRV RTRITKFLSA 370 380 390 400 410 420 TSAGNAEATI TFSKVKFLRN YILYCIRYGI ETVNIYGNKI QQQLTEAMDT FKVLFENRDP 430 440 450 460 470 480 NDVILDAGCK LYHEEKKEYQ QKRCGQRKQQ NLTDIILDKI KEKKITTAQQ WENIIEPEFK 490 500 510 520 530 540 IQLMKEFGLN VDSYVQRIVR IERTRIQQII KSKTLTEIMV EILNEEYIKN FTPGEDNSKL 550 560 570 580 590 600 QNIIQWIEYM FKENNINIIH FLAWNEIIKP KRYKKINGMV LEGITNAGKS LILDNLLAMV 610 620 630 640 650 660 KPEEIPRERD NSGFHLDQLP GAGSVLFEEP MITPVNVGTW KLLLEGKTIK TDVKNKDKEP 670 680 690 700 710 720 IERTPTWITT ATPITNNVHM NETSQILQRI KLYIFKKSIQ HREDKYTINA QIQNKLISRP 730 740 750 760 770 780 PGLVEPIHMA IVFVKNFKEI YKLIEEEDNA HTVNEKAIRL SEEAKQEAEE WQTALQWNTM 790 800 EEEQKENEKQ TEDQDKESEK ETATQ

References

[1]	"Complete nucleotide sequence and genomic organization of the Aedes albopictus parvovirus (AaPV) pathogenic for Aedes aegypti larvae." Boublik Y., Jousset F.X., Bergoin M. Virology 200:752-763(1994) [PubMed: 8178459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74945 Genomic DNA. Translation: CAA52899.1.
RefSeq	NP_694827.1. NC_004285.1.
3D structure databases
ProteinModelPortal	Q90185.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	955416.
Family and domain databases
InterPro	IPR014015. Helicase_SF3_DNA-vir. IPR001257. Parvovirus_NS1_helicase. [Graphical view]
Pfam	PF01057. Parvo_NS1. 2 hits. [Graphical view]
PROSITE	PS51206. SF3_HELICASE_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NS1_AADNV

Accession

Primary (citable) accession number: Q90185

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	November 1, 1996
Last modified:	September 21, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program