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Q90125

- CAPSD_GMDNV

UniProt

Q90125 - CAPSD_GMDNV

Protein

Capsid protein VP1

Gene

VP

Organism
Galleria mellonella densovirus (GmDNV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis By similarity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
    2. permeabilization of host organelle membrane involved in viral entry into host cell Source: UniProtKB-KW
    3. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Clathrin-mediated endocytosis of virus by host, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Viral penetration via permeabilization of host membrane, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Capsid protein VP1
    Alternative name(s):
    Coat protein VP1
    Structural protein VP1
    Gene namesi
    Name:VP
    OrganismiGalleria mellonella densovirus (GmDNV)
    Taxonomic identifieri37138 [NCBI]
    Taxonomic lineageiVirusesssDNA virusesParvoviridaeDensovirinaeAmbidensovirus
    Virus hostiGalleria mellonella (Greater wax moth) [TaxID: 7137]

    Subcellular locationi

    Virion Curated

    GO - Cellular componenti

    1. T=1 icosahedral viral capsid Source: UniProtKB-KW

    Keywords - Cellular componenti

    Capsid protein, T=1 icosahedral capsid protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 811811Capsid protein VP1PRO_0000039451Add
    BLAST

    Structurei

    Secondary structure

    1
    811
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi413 – 42210
    Turni435 – 4373
    Beta strandi439 – 44911
    Helixi455 – 4573
    Helixi461 – 4655
    Beta strandi476 – 48712
    Beta strandi506 – 5116
    Helixi513 – 5164
    Beta strandi529 – 5313
    Beta strandi543 – 5464
    Beta strandi548 – 5503
    Helixi555 – 5606
    Beta strandi569 – 5757
    Helixi578 – 5814
    Beta strandi584 – 5863
    Beta strandi590 – 5934
    Beta strandi596 – 6005
    Helixi607 – 6104
    Beta strandi611 – 6133
    Turni616 – 6216
    Beta strandi653 – 6553
    Beta strandi677 – 6793
    Beta strandi703 – 7064
    Turni709 – 7113
    Beta strandi727 – 7315
    Beta strandi750 – 76011
    Turni780 – 7823
    Beta strandi796 – 7983
    Beta strandi801 – 8033

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1DNVX-ray3.60A375-811[»]
    ProteinModelPortaliQ90125.
    SMRiQ90125. Positions 396-810.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ90125.

    Family & Domainsi

    Domaini

    The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.

    Family and domain databases

    InterProiIPR016184. Capsid/spike_ssDNA_virus.
    IPR003433. Capsid_VP4_densovirus.
    IPR013607. Parvovirus_coat_VP1_N.
    [Graphical view]
    PfamiPF02336. Denso_VP4. 1 hit.
    PF08398. Parvo_coat_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF88645. SSF88645. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative initiation. Align

    Isoform VP1 (identifier: Q90125-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSFFKNQLIH RARPGYRIIP ESTVTEDIEL GTIGEETPLL SEGVITAVEE    50
    GAIGLPEVAI GVAGAIGTHA HEWWRDRYAF KSVLTGNYTD LKGNPLKPRN 100
    AIPEKIKQLG KKIFQGDFNR AFPDNLKLET EKEKADLLRY YNHNRRLAGL 150
    SEAYPQGKGY AYAKSQKVLE AERRGLTVPG YKYLGPGNSL NRGQPINQID 200
    EDAKEHDEAY DKVKTSQEVS RADNTFVNKA LDHVVNAINF KETPGNAFGA 250
    AIGAIGIGTK QAIEKYSGVI YPSVSGMSRH INPRYINQPN WKDYIAEGNS 300
    KNWVGYSNLP DDFFQEETLS DSPMQEATKR KADSPAVETP AKKGTTGVNV 350
    NSQSTDPQNP SSSGATTDLD VTMAMSLPGT GSGTSSGGGN TQGQDVYIIP 400
    RPFSNFGKKL STYTKSHKFM IFGLANNVIG PTGTGTTAVN RLLTTCLAEI 450
    PWQKLPLYMN QSEFDLLPPG SRVVECNVKV IFRTNRIAFE TSSTVTKQAT 500
    LNQISNVQTA IGLNKLGWGI NRAFTAFQSD QPMIPTATTA PKYEPVTGDT 550
    GYRGMIADYY GADSTNDTAF GNAGNYPHHQ VSSFTFLQNY YCMYQQTNQG 600
    TGGWPCLAEH LQQFDSKTVN NQCLIDVTYK PKMGLIKSPL NYKIIGQPTV 650
    KGTISVGDNL VNMRGAVVTN PPEATQNVAE STHNLTRNFP ADLFNIYSDI 700
    EKSQVLHKGP WGHENPQIQP SVHIGIQAVP ALTTGALLIN SSPLNSWTDS 750
    MGYIDVMSSC TVMEAQPTHF PFSTEANTNP GNTIYRINLT PNSLTSAFNG 800
    LYGNGATLGN V 811
    Length:811
    Mass (Da):88,542
    Last modified:November 1, 1996 - v1
    Checksum:i0A61B09172DF99B5
    GO
    Isoform VP2 (identifier: Q90125-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-276: Missing.

    Show »
    Length:535
    Mass (Da):58,155
    Checksum:i13163DB3AC4ED572
    GO
    Isoform VP3 (identifier: Q90125-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-323: Missing.

    Show »
    Length:488
    Mass (Da):52,598
    Checksum:i5A2DF8B49527888B
    GO
    Isoform VP4 (identifier: Q90125-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-374: Missing.

    Show »
    Length:437
    Mass (Da):47,394
    Checksum:i7652FD77DB83A711
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 374374Missing in isoform VP4. CuratedVSP_018952Add
    BLAST
    Alternative sequencei1 – 323323Missing in isoform VP3. CuratedVSP_018951Add
    BLAST
    Alternative sequencei1 – 276276Missing in isoform VP2. CuratedVSP_018950Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32896 Genomic DNA. Translation: AAA66966.1.
    L32896 Genomic DNA. Translation: AAA66964.1.
    L32896 Genomic DNA. Translation: AAA66965.1.
    L32896 Genomic DNA. Translation: AAA66967.1.
    RefSeqiNP_694830.1. NC_004286.1. [Q90125-1]
    NP_694831.1. NC_004286.1. [Q90125-2]
    NP_694832.1. NC_004286.1. [Q90125-3]
    NP_694833.1. NC_004286.1. [Q90125-4]

    Genome annotation databases

    GeneIDi2546231.

    Keywords - Coding sequence diversityi

    Alternative initiation

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32896 Genomic DNA. Translation: AAA66966.1 .
    L32896 Genomic DNA. Translation: AAA66964.1 .
    L32896 Genomic DNA. Translation: AAA66965.1 .
    L32896 Genomic DNA. Translation: AAA66967.1 .
    RefSeqi NP_694830.1. NC_004286.1. [Q90125-1 ]
    NP_694831.1. NC_004286.1. [Q90125-2 ]
    NP_694832.1. NC_004286.1. [Q90125-3 ]
    NP_694833.1. NC_004286.1. [Q90125-4 ]

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1DNV X-ray 3.60 A 375-811 [» ]
    ProteinModelPortali Q90125.
    SMRi Q90125. Positions 396-810.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2546231.

    Miscellaneous databases

    EvolutionaryTracei Q90125.

    Family and domain databases

    InterProi IPR016184. Capsid/spike_ssDNA_virus.
    IPR003433. Capsid_VP4_densovirus.
    IPR013607. Parvovirus_coat_VP1_N.
    [Graphical view ]
    Pfami PF02336. Denso_VP4. 1 hit.
    PF08398. Parvo_coat_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88645. SSF88645. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Organization and expression of the ambisense genome of densonucleosis virus of Galleria mellonella (GmDNV)."
      Tijssen P.
      Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution."
      Simpson A.A., Chipman P.R., Baker T.S., Tijssen P., Rossmann M.G.
      Structure 6:1355-1367(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 396-811.

    Entry informationi

    Entry nameiCAPSD_GMDNV
    AccessioniPrimary (citable) accession number: Q90125
    Secondary accession number(s): Q90126, Q90127, Q90128
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3