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Q90125

- CAPSD_GMDNV

UniProt

Q90125 - CAPSD_GMDNV

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Protein

Capsid protein VP1

Gene

VP

Organism
Galleria mellonella densovirus (GmDNV)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. clathrin-mediated endocytosis of virus by host cell Source: UniProtKB-KW
  2. permeabilization of host organelle membrane involved in viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Clathrin-mediated endocytosis of virus by host, Host-virus interaction, Viral attachment to host cell, Viral penetration into host cytoplasm, Viral penetration via permeabilization of host membrane, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Capsid protein VP1
Alternative name(s):
Coat protein VP1
Structural protein VP1
Gene namesi
Name:VP
OrganismiGalleria mellonella densovirus (GmDNV)
Taxonomic identifieri37138 [NCBI]
Taxonomic lineageiVirusesssDNA virusesParvoviridaeDensovirinaeAmbidensovirus
Virus hostiGalleria mellonella (Greater wax moth) [TaxID: 7137]

Subcellular locationi

Virion Curated

GO - Cellular componenti

  1. T=1 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, T=1 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 811811Capsid protein VP1PRO_0000039451Add
BLAST

Structurei

Secondary structure

1
811
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi413 – 42210
Turni435 – 4373
Beta strandi439 – 44911
Helixi455 – 4573
Helixi461 – 4655
Beta strandi476 – 48712
Beta strandi506 – 5116
Helixi513 – 5164
Beta strandi529 – 5313
Beta strandi543 – 5464
Beta strandi548 – 5503
Helixi555 – 5606
Beta strandi569 – 5757
Helixi578 – 5814
Beta strandi584 – 5863
Beta strandi590 – 5934
Beta strandi596 – 6005
Helixi607 – 6104
Beta strandi611 – 6133
Turni616 – 6216
Beta strandi653 – 6553
Beta strandi677 – 6793
Beta strandi703 – 7064
Turni709 – 7113
Beta strandi727 – 7315
Beta strandi750 – 76011
Turni780 – 7823
Beta strandi796 – 7983
Beta strandi801 – 8033

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DNVX-ray3.60A375-811[»]
ProteinModelPortaliQ90125.
SMRiQ90125. Positions 396-810.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90125.

Family & Domainsi

Domaini

The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.

Family and domain databases

InterProiIPR016184. Capsid/spike_ssDNA_virus.
IPR003433. Capsid_VP4_densovirus.
IPR013607. Parvovirus_coat_VP1_N.
[Graphical view]
PfamiPF02336. Denso_VP4. 1 hit.
PF08398. Parvo_coat_N. 1 hit.
[Graphical view]
SUPFAMiSSF88645. SSF88645. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative initiation. Align

Isoform VP1 (identifier: Q90125-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFFKNQLIH RARPGYRIIP ESTVTEDIEL GTIGEETPLL SEGVITAVEE
60 70 80 90 100
GAIGLPEVAI GVAGAIGTHA HEWWRDRYAF KSVLTGNYTD LKGNPLKPRN
110 120 130 140 150
AIPEKIKQLG KKIFQGDFNR AFPDNLKLET EKEKADLLRY YNHNRRLAGL
160 170 180 190 200
SEAYPQGKGY AYAKSQKVLE AERRGLTVPG YKYLGPGNSL NRGQPINQID
210 220 230 240 250
EDAKEHDEAY DKVKTSQEVS RADNTFVNKA LDHVVNAINF KETPGNAFGA
260 270 280 290 300
AIGAIGIGTK QAIEKYSGVI YPSVSGMSRH INPRYINQPN WKDYIAEGNS
310 320 330 340 350
KNWVGYSNLP DDFFQEETLS DSPMQEATKR KADSPAVETP AKKGTTGVNV
360 370 380 390 400
NSQSTDPQNP SSSGATTDLD VTMAMSLPGT GSGTSSGGGN TQGQDVYIIP
410 420 430 440 450
RPFSNFGKKL STYTKSHKFM IFGLANNVIG PTGTGTTAVN RLLTTCLAEI
460 470 480 490 500
PWQKLPLYMN QSEFDLLPPG SRVVECNVKV IFRTNRIAFE TSSTVTKQAT
510 520 530 540 550
LNQISNVQTA IGLNKLGWGI NRAFTAFQSD QPMIPTATTA PKYEPVTGDT
560 570 580 590 600
GYRGMIADYY GADSTNDTAF GNAGNYPHHQ VSSFTFLQNY YCMYQQTNQG
610 620 630 640 650
TGGWPCLAEH LQQFDSKTVN NQCLIDVTYK PKMGLIKSPL NYKIIGQPTV
660 670 680 690 700
KGTISVGDNL VNMRGAVVTN PPEATQNVAE STHNLTRNFP ADLFNIYSDI
710 720 730 740 750
EKSQVLHKGP WGHENPQIQP SVHIGIQAVP ALTTGALLIN SSPLNSWTDS
760 770 780 790 800
MGYIDVMSSC TVMEAQPTHF PFSTEANTNP GNTIYRINLT PNSLTSAFNG
810
LYGNGATLGN V
Length:811
Mass (Da):88,542
Last modified:November 1, 1996 - v1
Checksum:i0A61B09172DF99B5
GO
Isoform VP2 (identifier: Q90125-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.

Show »
Length:535
Mass (Da):58,155
Checksum:i13163DB3AC4ED572
GO
Isoform VP3 (identifier: Q90125-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.

Show »
Length:488
Mass (Da):52,598
Checksum:i5A2DF8B49527888B
GO
Isoform VP4 (identifier: Q90125-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-374: Missing.

Show »
Length:437
Mass (Da):47,394
Checksum:i7652FD77DB83A711
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 374374Missing in isoform VP4. CuratedVSP_018952Add
BLAST
Alternative sequencei1 – 323323Missing in isoform VP3. CuratedVSP_018951Add
BLAST
Alternative sequencei1 – 276276Missing in isoform VP2. CuratedVSP_018950Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32896 Genomic DNA. Translation: AAA66966.1.
L32896 Genomic DNA. Translation: AAA66964.1.
L32896 Genomic DNA. Translation: AAA66965.1.
L32896 Genomic DNA. Translation: AAA66967.1.
RefSeqiNP_694830.1. NC_004286.1. [Q90125-1]
NP_694831.1. NC_004286.1. [Q90125-2]
NP_694832.1. NC_004286.1. [Q90125-3]
NP_694833.1. NC_004286.1. [Q90125-4]

Genome annotation databases

GeneIDi2546231.

Keywords - Coding sequence diversityi

Alternative initiation

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32896 Genomic DNA. Translation: AAA66966.1 .
L32896 Genomic DNA. Translation: AAA66964.1 .
L32896 Genomic DNA. Translation: AAA66965.1 .
L32896 Genomic DNA. Translation: AAA66967.1 .
RefSeqi NP_694830.1. NC_004286.1. [Q90125-1 ]
NP_694831.1. NC_004286.1. [Q90125-2 ]
NP_694832.1. NC_004286.1. [Q90125-3 ]
NP_694833.1. NC_004286.1. [Q90125-4 ]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DNV X-ray 3.60 A 375-811 [» ]
ProteinModelPortali Q90125.
SMRi Q90125. Positions 396-810.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2546231.

Miscellaneous databases

EvolutionaryTracei Q90125.

Family and domain databases

InterProi IPR016184. Capsid/spike_ssDNA_virus.
IPR003433. Capsid_VP4_densovirus.
IPR013607. Parvovirus_coat_VP1_N.
[Graphical view ]
Pfami PF02336. Denso_VP4. 1 hit.
PF08398. Parvo_coat_N. 1 hit.
[Graphical view ]
SUPFAMi SSF88645. SSF88645. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Organization and expression of the ambisense genome of densonucleosis virus of Galleria mellonella (GmDNV)."
    Tijssen P.
    Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution."
    Simpson A.A., Chipman P.R., Baker T.S., Tijssen P., Rossmann M.G.
    Structure 6:1355-1367(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 396-811.

Entry informationi

Entry nameiCAPSD_GMDNV
AccessioniPrimary (citable) accession number: Q90125
Secondary accession number(s): Q90126, Q90127, Q90128
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3