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Q90125 (CAPSD_GMDNV) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Capsid protein VP1
Alternative name(s):
Coat protein VP1
Structural protein VP1
Gene names
Name:VP
OrganismGalleria mellonella densovirus (GmDNV)
Taxonomic identifier37138 [NCBI]
Taxonomic lineageViruses › ssDNA viruses › Parvoviridae › Densovirinae › Densovirus
Virus hostGalleria mellonella (Greater wax moth) [TaxID: 7137]

Protein attributes

Sequence length811 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis By similarity.

Subcellular location

Virion Potential.

Domain

The N-terminus of VP1 is sequestered within the mature capsid. It contains a phospholipase A2-like region and putative nuclear localization signals.

Alternative products

This entry describes 4 isoforms produced by alternative initiation. [Align] [Select]
Isoform VP1 (identifier: Q90125-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform VP2 (identifier: Q90125-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-276: Missing.
Isoform VP3 (identifier: Q90125-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-323: Missing.
Isoform VP4 (identifier: Q90125-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-374: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 811811Capsid protein VP1
PRO_0000039451

Natural variations

Alternative sequence1 – 374374Missing in isoform VP4.
VSP_018952
Alternative sequence1 – 323323Missing in isoform VP3.
VSP_018951
Alternative sequence1 – 276276Missing in isoform VP2.
VSP_018950

Secondary structure

1 .......................................................... 811
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform VP1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0A61B09172DF99B5

FASTA81188,542
        10         20         30         40         50         60 
MSFFKNQLIH RARPGYRIIP ESTVTEDIEL GTIGEETPLL SEGVITAVEE GAIGLPEVAI 

        70         80         90        100        110        120 
GVAGAIGTHA HEWWRDRYAF KSVLTGNYTD LKGNPLKPRN AIPEKIKQLG KKIFQGDFNR 

       130        140        150        160        170        180 
AFPDNLKLET EKEKADLLRY YNHNRRLAGL SEAYPQGKGY AYAKSQKVLE AERRGLTVPG 

       190        200        210        220        230        240 
YKYLGPGNSL NRGQPINQID EDAKEHDEAY DKVKTSQEVS RADNTFVNKA LDHVVNAINF 

       250        260        270        280        290        300 
KETPGNAFGA AIGAIGIGTK QAIEKYSGVI YPSVSGMSRH INPRYINQPN WKDYIAEGNS 

       310        320        330        340        350        360 
KNWVGYSNLP DDFFQEETLS DSPMQEATKR KADSPAVETP AKKGTTGVNV NSQSTDPQNP 

       370        380        390        400        410        420 
SSSGATTDLD VTMAMSLPGT GSGTSSGGGN TQGQDVYIIP RPFSNFGKKL STYTKSHKFM 

       430        440        450        460        470        480 
IFGLANNVIG PTGTGTTAVN RLLTTCLAEI PWQKLPLYMN QSEFDLLPPG SRVVECNVKV 

       490        500        510        520        530        540 
IFRTNRIAFE TSSTVTKQAT LNQISNVQTA IGLNKLGWGI NRAFTAFQSD QPMIPTATTA 

       550        560        570        580        590        600 
PKYEPVTGDT GYRGMIADYY GADSTNDTAF GNAGNYPHHQ VSSFTFLQNY YCMYQQTNQG 

       610        620        630        640        650        660 
TGGWPCLAEH LQQFDSKTVN NQCLIDVTYK PKMGLIKSPL NYKIIGQPTV KGTISVGDNL 

       670        680        690        700        710        720 
VNMRGAVVTN PPEATQNVAE STHNLTRNFP ADLFNIYSDI EKSQVLHKGP WGHENPQIQP 

       730        740        750        760        770        780 
SVHIGIQAVP ALTTGALLIN SSPLNSWTDS MGYIDVMSSC TVMEAQPTHF PFSTEANTNP 

       790        800        810 
GNTIYRINLT PNSLTSAFNG LYGNGATLGN V

« Hide

Isoform VP2 [UniParc].

Checksum: 13163DB3AC4ED572
Show »

FASTA53558,155
Isoform VP3 [UniParc].

Checksum: 5A2DF8B49527888B
Show »

FASTA48852,598
Isoform VP4 [UniParc].

Checksum: 7652FD77DB83A711
Show »

FASTA43747,394

References

[1]"Organization and expression of the ambisense genome of densonucleosis virus of Galleria mellonella (GmDNV)."
Tijssen P.
Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution."
Simpson A.A., Chipman P.R., Baker T.S., Tijssen P., Rossmann M.G.
Structure 6:1355-1367(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 396-811.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L32896 Genomic DNA. Translation: AAA66966.1.
L32896 Genomic DNA. Translation: AAA66964.1.
L32896 Genomic DNA. Translation: AAA66965.1.
L32896 Genomic DNA. Translation: AAA66967.1.
RefSeqNP_694830.1. NC_004286.1.
NP_694831.1. NC_004286.1.
NP_694832.1. NC_004286.1.
NP_694833.1. NC_004286.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1DNVX-ray3.60A375-811[»]
ProteinModelPortalQ90125.
SMRQ90125. Positions 396-810.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2546231.

Family and domain databases

InterProIPR016184. Capsid/spike_ssDNA_virus.
IPR003433. Capsid_VP4_densovirus.
IPR013607. Parvovirus_coat_VP1_N.
[Graphical view]
PfamPF02336. Denso_VP4. 1 hit.
PF08398. Parvo_coat_N. 1 hit.
[Graphical view]
SUPFAMSSF88645. Capsid/spike_ssDNA_virus. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ90125.

Entry information

Entry nameCAPSD_GMDNV
AccessionPrimary (citable) accession number: Q90125
Secondary accession number(s): Q90126, Q90127, Q90128
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

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