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Q90033

- KITH_YMTV5

UniProt

Q90033 - KITH_YMTV5

Protein

Thymidine kinase

Gene

TK

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei85 – 851Proton acceptorSequence Analysis
    Binding sitei115 – 1151Substrate; via amide nitrogenBy similarity
    Metal bindingi140 – 1401ZincBy similarity
    Metal bindingi143 – 1431ZincBy similarity
    Metal bindingi172 – 1721ZincBy similarity
    Metal bindingi175 – 1751ZincBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 208ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. thymidine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinase (EC:2.7.1.21)
    Gene namesi
    Name:TK
    Ordered Locus Names:66R
    ORF Names:I7R
    OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
    Taxonomic identifieri928314 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
    Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
    Homo sapiens (Human) [TaxID: 9606]
    Macaca (macaques) [TaxID: 9539]
    Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
    ProteomesiUP000008596: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Thymidine kinasePRO_0000174945Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ90033.
    SMRiQ90033. Positions 6-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni159 – 1635Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the thymidine kinase family.Curated

    Family and domain databases

    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q90033-1 [UniParc]FASTAAdd to Basket

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    MNSRSGYIHI ILGPMFSGKS TELIRLLKRY QVAMYTCLVI KYSKDERYGR    50
    GLVTHDNDSV PAIPVNSLNE INCNDINADV IGIDEGQFFP DIVEFCDYMA 100
    NNGKILIVAA LDGTFLRQPF GNILNLIPRA EYVLKLTAVC MICFGSASFS 150
    KRISDEQEIE IIGGKEKYQS VCRVCYFKIN N 181
    Length:181
    Mass (Da):20,382
    Last modified:November 1, 1996 - v1
    Checksum:iB96DA15132486AA9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07422.1.
    RefSeqiNP_938321.1. NC_005179.1.

    Genome annotation databases

    GeneIDi2943610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY386371 Genomic DNA. Translation: AAR07422.1 .
    RefSeqi NP_938321.1. NC_005179.1.

    3D structure databases

    ProteinModelPortali Q90033.
    SMRi Q90033. Positions 6-178.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943610.

    Family and domain databases

    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the thymidine kinase gene of Yaba virus."
      Amano H., Ueda Y., Miyamura T.
      J. Gen. Virol. 76:1109-1115(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
      Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
      J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKITH_YMTV5
    AccessioniPrimary (citable) accession number: Q90033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3