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Q90033 (KITH_YMTV5) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:TK
Ordered Locus Names:66R
ORF Names:I7R
OrganismYaba monkey tumor virus (strain VR587) (YMTV) [Reference proteome]
Taxonomic identifier928314 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Thymidine kinase
PRO_0000174945

Regions

Nucleotide binding13 – 208ATP By similarity
Region159 – 1635Substrate binding By similarity

Sites

Active site851Proton acceptor Potential
Metal binding1401Zinc By similarity
Metal binding1431Zinc By similarity
Metal binding1721Zinc By similarity
Metal binding1751Zinc By similarity
Binding site1151Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90033 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B96DA15132486AA9

FASTA18120,382
        10         20         30         40         50         60 
MNSRSGYIHI ILGPMFSGKS TELIRLLKRY QVAMYTCLVI KYSKDERYGR GLVTHDNDSV 

        70         80         90        100        110        120 
PAIPVNSLNE INCNDINADV IGIDEGQFFP DIVEFCDYMA NNGKILIVAA LDGTFLRQPF 

       130        140        150        160        170        180 
GNILNLIPRA EYVLKLTAVC MICFGSASFS KRISDEQEIE IIGGKEKYQS VCRVCYFKIN 


N 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of the thymidine kinase gene of Yaba virus."
Amano H., Ueda Y., Miyamura T.
J. Gen. Virol. 76:1109-1115(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY386371 Genomic DNA. Translation: AAR07422.1.
RefSeqNP_938321.1. NC_005179.1.

3D structure databases

ProteinModelPortalQ90033.
SMRQ90033. Positions 6-178.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943610.

Family and domain databases

InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_YMTV5
AccessionPrimary (citable) accession number: Q90033
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families