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Q90033

- KITH_YMTV5

UniProt

Q90033 - KITH_YMTV5

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Protein

Thymidine kinase

Gene

TK

Organism
Yaba monkey tumor virus (strain VR587) (YMTV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei85 – 851Proton acceptorSequence Analysis
Binding sitei115 – 1151Substrate; via amide nitrogenBy similarity
Metal bindingi140 – 1401ZincBy similarity
Metal bindingi143 – 1431ZincBy similarity
Metal bindingi172 – 1721ZincBy similarity
Metal bindingi175 – 1751ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 208ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. thymidine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:TK
Ordered Locus Names:66R
ORF Names:I7R
OrganismiYaba monkey tumor virus (strain VR587) (YMTV)
Taxonomic identifieri928314 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeYatapoxvirus
Virus hostiErythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]
ProteomesiUP000008596: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Thymidine kinasePRO_0000174945Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ90033.
SMRiQ90033. Positions 6-178.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni159 – 1635Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the thymidine kinase family.Curated

Family and domain databases

InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q90033-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSRSGYIHI ILGPMFSGKS TELIRLLKRY QVAMYTCLVI KYSKDERYGR
60 70 80 90 100
GLVTHDNDSV PAIPVNSLNE INCNDINADV IGIDEGQFFP DIVEFCDYMA
110 120 130 140 150
NNGKILIVAA LDGTFLRQPF GNILNLIPRA EYVLKLTAVC MICFGSASFS
160 170 180
KRISDEQEIE IIGGKEKYQS VCRVCYFKIN N
Length:181
Mass (Da):20,382
Last modified:November 1, 1996 - v1
Checksum:iB96DA15132486AA9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY386371 Genomic DNA. Translation: AAR07422.1.
RefSeqiNP_938321.1. NC_005179.1.

Genome annotation databases

GeneIDi2943610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY386371 Genomic DNA. Translation: AAR07422.1 .
RefSeqi NP_938321.1. NC_005179.1.

3D structure databases

ProteinModelPortali Q90033.
SMRi Q90033. Positions 6-178.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943610.

Family and domain databases

InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the thymidine kinase gene of Yaba virus."
    Amano H., Ueda Y., Miyamura T.
    J. Gen. Virol. 76:1109-1115(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus."
    Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G.
    J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKITH_YMTV5
AccessioniPrimary (citable) accession number: Q90033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3