Q90033 (KITH_YMTV5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidine kinase
EC=2.7.1.21

Gene names

Name:	TK
Ordered Locus Names:	66R
ORF Names:	I7R

Organism

Yaba monkey tumor virus (strain VR587) (YMTV) [Reference proteome]

Taxonomic identifier

928314 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Poxviridae › Chordopoxvirinae › Yatapoxvirus › Yaba monkey tumor virus

Virus host

Erythrocebus patas (Red guenon) (Cercopithecus patas) [TaxID: 9538]
Homo sapiens (Human) [TaxID: 9606]
Macaca (macaques) [TaxID: 9539]
Papio hamadryas (Hamadryas baboon) [TaxID: 9557]

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + thymidine = ADP + thymidine 5'-phosphate.
Sequence similarities	Belongs to the thymidine kinase family.

Ontologies

Keywords
Biological process	DNA synthesis
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW thymidine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Thymidine kinase		PRO_0000174945
Regions
	Nucleotide binding	13 – 20	8	ATP By similarity
	Region	159 – 163	5	Substrate binding By similarity
Sites
	Active site	85	1	Proton acceptor Potential
	Metal binding	140	1	Zinc By similarity
	Metal binding	143	1	Zinc By similarity
	Metal binding	172	1	Zinc By similarity
	Metal binding	175	1	Zinc By similarity
	Binding site	115	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90033 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: B96DA15132486AA9	FASTA	181	20,382
	10 20 30 40 50 60 MNSRSGYIHI ILGPMFSGKS TELIRLLKRY QVAMYTCLVI KYSKDERYGR GLVTHDNDSV 70 80 90 100 110 120 PAIPVNSLNE INCNDINADV IGIDEGQFFP DIVEFCDYMA NNGKILIVAA LDGTFLRQPF 130 140 150 160 170 180 GNILNLIPRA EYVLKLTAVC MICFGSASFS KRISDEQEIE IIGGKEKYQS VCRVCYFKIN N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of the thymidine kinase gene of Yaba virus." Amano H., Ueda Y., Miyamura T. J. Gen. Virol. 76:1109-1115(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genomic sequence and comparative analysis of the tumorigenic poxvirus Yaba monkey tumor virus." Brunetti C.R., Amano H., Ueda Y., Qin J., Miyamura T., Suzuki T., Li X., Barrett J.W., McFadden G. J. Virol. 77:13335-13347(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY386371 Genomic DNA. Translation: AAR07422.1.
RefSeq	NP_938321.1. NC_005179.1.
3D structure databases
ProteinModelPortal	Q90033.
SMR	Q90033. Positions 6-178.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2943610.
Phylogenomic databases
ProtClustDB	CLSP2509781.
Family and domain databases
InterPro	IPR027417. P-loop_NTPase. IPR001267. Thymidine_kinase. IPR020633. Thymidine_kinase_CS. [Graphical view]
PANTHER	PTHR11441. PTHR11441. 1 hit.
Pfam	PF00265. TK. 1 hit. [Graphical view]
PIRSF	PIRSF035805. TK_cell. 1 hit.
SUPFAM	SSF52540. SSF52540. 1 hit.
PROSITE	PS00603. TK_CELLULAR_TYPE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KITH_YMTV5

Accession

Primary (citable) accession number: Q90033

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	May 29, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program