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Q90030 (DUT_SUHVK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase

Short name=dUTPase
EC=3.6.1.23
Alternative name(s):
dUTP pyrophosphatase
Gene names
Name:UL50
OrganismSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Taxonomic identifier33703 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length268 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.

Catalytic activity

dUTP + H2O = dUMP + diphosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the dUTPase family.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
Gene Ontology (GO)
   Biological_processdUTP metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functiondUTP diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 268268Deoxyuridine 5'-triphosphate nucleotidohydrolase
PRO_0000182964

Regions

Region172 – 1743Substrate binding By similarity

Sites

Binding site851Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q90030 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 79D7CFA999204776

FASTA26828,618
        10         20         30         40         50         60 
MEESAGATSA QSAATSVSES PAEETILVCA SEPVTVDGGR LLVCRSPGPE GFYKVPLGLK 

        70         80         90        100        110        120 
VALPTGYAML VAQRGGGRTT NGIVDAGFRG EVQAIVAPGR PRAQFYCTPL RLAPGIATDV 

       130        140        150        160        170        180 
PFFEVFAPKR DEDAGYDIPC PRELVLPPGG AETVTLPVHR TDGRHWAYVF GRSSLNLRGI 

       190        200        210        220        230        240 
VVFPTPWESG PCRFRIQNRG AHPVTLESGQ RVAQLVLTRE PLGWITGRSP FPATPRAPMQ 

       250        260 
HRPAWLFARD FVAPSSARGA RGFGSTGL 

« Hide

References

[1]"Identification and characterization of pseudorabies virus dUTPase."
Joens A., Mettenleiter T.C.
J. Virol. 70:1242-1245(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster."
Baumeister J., Klupp B.G., Mettenleiter T.C.
J. Virol. 69:5560-5567(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-268.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U38547 Genomic DNA. Translation: AAB02855.1.
X87246 Genomic DNA. Translation: CAA60688.1.
RefSeqYP_068324.1. NC_006151.1.

3D structure databases

ProteinModelPortalQ90030.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2952537.

Family and domain databases

Gene3D2.70.40.10. 2 hits.
InterProIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMSSF51283. SSF51283. 3 hits.
ProtoNetSearch...

Entry information

Entry nameDUT_SUHVK
AccessionPrimary (citable) accession number: Q90030
Secondary accession number(s): Q85226
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families