Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL50
OrganismiSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Taxonomic identifieri33703 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182964Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ90030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Substrate bindingUniRule annotation
Regioni263 – 2642Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Phylogenomic databases

KOiK01520.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 2 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

Q90030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESAGATSA QSAATSVSES PAEETILVCA SEPVTVDGGR LLVCRSPGPE
60 70 80 90 100
GFYKVPLGLK VALPTGYAML VAQRGGGRTT NGIVDAGFRG EVQAIVAPGR
110 120 130 140 150
PRAQFYCTPL RLAPGIATDV PFFEVFAPKR DEDAGYDIPC PRELVLPPGG
160 170 180 190 200
AETVTLPVHR TDGRHWAYVF GRSSLNLRGI VVFPTPWESG PCRFRIQNRG
210 220 230 240 250
AHPVTLESGQ RVAQLVLTRE PLGWITGRSP FPATPRAPMQ HRPAWLFARD
260
FVAPSSARGA RGFGSTGL
Length:268
Mass (Da):28,618
Last modified:November 1, 1996 - v1
Checksum:i79D7CFA999204776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38547 Genomic DNA. Translation: AAB02855.1.
X87246 Genomic DNA. Translation: CAA60688.1.
RefSeqiYP_068324.1. NC_006151.1.

Genome annotation databases

GeneIDi2952537.
KEGGivg:2952537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38547 Genomic DNA. Translation: AAB02855.1.
X87246 Genomic DNA. Translation: CAA60688.1.
RefSeqiYP_068324.1. NC_006151.1.

3D structure databases

ProteinModelPortaliQ90030.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2952537.
KEGGivg:2952537.

Phylogenomic databases

KOiK01520.

Family and domain databases

CDDicd07557. trimeric_dUTPase. 1 hit.
Gene3Di2.70.40.10. 2 hits.
HAMAPiMF_04031. HSV_DUT. 1 hit.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
IPR033704. dUTPase_trimeric.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiDUT_SUHVK
AccessioniPrimary (citable) accession number: Q90030
Secondary accession number(s): Q85226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.