Q90030 (DUT_SUHVK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase
Short name=dUTPase
EC=3.6.1.23

Alternative name(s):
dUTP pyrophosphatase

Gene names

Name:

UL50

Organism

Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))

Taxonomic identifier

33703 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Varicellovirus › Suid herpesvirus 1

Virus host

Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA By similarity.
Catalytic activity	dUTP + H2O = dUMP + diphosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the dUTPase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Gene Ontology (GO)
Biological_process	dUTP metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	dUTP diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 268	268	Deoxyuridine 5'-triphosphate nucleotidohydrolase		PRO_0000182964
Regions
	Region	172 – 174	3	Substrate binding By similarity
Sites
	Binding site	85	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q90030 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 79D7CFA999204776	FASTA	268	28,618
	10 20 30 40 50 60 MEESAGATSA QSAATSVSES PAEETILVCA SEPVTVDGGR LLVCRSPGPE GFYKVPLGLK 70 80 90 100 110 120 VALPTGYAML VAQRGGGRTT NGIVDAGFRG EVQAIVAPGR PRAQFYCTPL RLAPGIATDV 130 140 150 160 170 180 PFFEVFAPKR DEDAGYDIPC PRELVLPPGG AETVTLPVHR TDGRHWAYVF GRSSLNLRGI 190 200 210 220 230 240 VVFPTPWESG PCRFRIQNRG AHPVTLESGQ RVAQLVLTRE PLGWITGRSP FPATPRAPMQ 250 260 HRPAWLFARD FVAPSSARGA RGFGSTGL

References

[1]	"Identification and characterization of pseudorabies virus dUTPase." Joens A., Mettenleiter T.C. J. Virol. 70:1242-1245(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster." Baumeister J., Klupp B.G., Mettenleiter T.C. J. Virol. 69:5560-5567(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-268.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U38547 Genomic DNA. Translation: AAB02855.1. X87246 Genomic DNA. Translation: CAA60688.1.
RefSeq	YP_068324.1. NC_006151.1.
3D structure databases
ProteinModelPortal	Q90030.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2952537.
Phylogenomic databases
ProtClustDB	PHA3127.
Family and domain databases
InterPro	IPR008180. dUTP_pyroPase. [Graphical view]
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUT_SUHVK

Accession

Primary (citable) accession number: Q90030
Secondary accession number(s): Q85226

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program