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Q90030

- DUT_SUHVK

UniProt

Q90030 - DUT_SUHVK

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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

UL50

Organism
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.By similarity

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate; via amide nitrogenBy similarity

GO - Molecular functioni

  1. dUTP diphosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. dUTP metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase (EC:3.6.1.23)
Short name:
dUTPase
Alternative name(s):
dUTP pyrophosphatase
Gene namesi
Name:UL50
OrganismiSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Taxonomic identifieri33703 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Deoxyuridine 5'-triphosphate nucleotidohydrolasePRO_0000182964Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ90030.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni172 – 1743Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the dUTPase family.Curated

Family and domain databases

Gene3Di2.70.40.10. 2 hits.
InterProiIPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 3 hits.

Sequencei

Sequence statusi: Complete.

Q90030-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEESAGATSA QSAATSVSES PAEETILVCA SEPVTVDGGR LLVCRSPGPE
60 70 80 90 100
GFYKVPLGLK VALPTGYAML VAQRGGGRTT NGIVDAGFRG EVQAIVAPGR
110 120 130 140 150
PRAQFYCTPL RLAPGIATDV PFFEVFAPKR DEDAGYDIPC PRELVLPPGG
160 170 180 190 200
AETVTLPVHR TDGRHWAYVF GRSSLNLRGI VVFPTPWESG PCRFRIQNRG
210 220 230 240 250
AHPVTLESGQ RVAQLVLTRE PLGWITGRSP FPATPRAPMQ HRPAWLFARD
260
FVAPSSARGA RGFGSTGL
Length:268
Mass (Da):28,618
Last modified:November 1, 1996 - v1
Checksum:i79D7CFA999204776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38547 Genomic DNA. Translation: AAB02855.1.
X87246 Genomic DNA. Translation: CAA60688.1.
RefSeqiYP_068324.1. NC_006151.1.

Genome annotation databases

GeneIDi2952537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38547 Genomic DNA. Translation: AAB02855.1 .
X87246 Genomic DNA. Translation: CAA60688.1 .
RefSeqi YP_068324.1. NC_006151.1.

3D structure databases

ProteinModelPortali Q90030.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2952537.

Family and domain databases

Gene3Di 2.70.40.10. 2 hits.
InterProi IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view ]
Pfami PF00692. dUTPase. 1 hit.
[Graphical view ]
SUPFAMi SSF51283. SSF51283. 3 hits.
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of pseudorabies virus dUTPase."
    Joens A., Mettenleiter T.C.
    J. Virol. 70:1242-1245(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Pseudorabies virus and equine herpesvirus 1 share a nonessential gene which is absent in other herpesviruses and located adjacent to a highly conserved gene cluster."
    Baumeister J., Klupp B.G., Mettenleiter T.C.
    J. Virol. 69:5560-5567(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 196-268.

Entry informationi

Entry nameiDUT_SUHVK
AccessioniPrimary (citable) accession number: Q90030
Secondary accession number(s): Q85226
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3