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Protein

Deoxyuridine 5'-triphosphate nucleotidohydrolase

Gene

DUT

Organism
Suid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in nucleotide metabolism: produces dUMP, the immediate precursor of thymidine nucleotides and decreases the intracellular concentration of dUTP to avoid uracil incorporation into viral DNA.UniRule annotation

Catalytic activityi

dUTP + H2O = dUMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolaseUniRule annotation (EC:3.6.1.23UniRule annotation)
Short name:
dUTPaseUniRule annotation
Alternative name(s):
dUTP pyrophosphataseUniRule annotation
Gene namesi
Name:DUTUniRule annotation
Ordered Locus Names:UL50
OrganismiSuid herpesvirus 1 (strain Kaplan) (SuHV-1) (Pseudorabies virus (strain Kaplan))
Taxonomic identifieri33703 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeVaricellovirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829641 – 268Deoxyuridine 5'-triphosphate nucleotidohydrolaseAdd BLAST268

Proteomic databases

PRIDEiQ90030

Structurei

3D structure databases

ProteinModelPortaliQ90030
SMRiQ90030
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni172 – 174Substrate bindingUniRule annotation3
Regioni263 – 264Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the dUTPase family.UniRule annotation

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 2 hits
HAMAPiMF_04031 HSV_DUT, 1 hit
InterProiView protein in InterPro
IPR029054 dUTPase-like
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
IPR034745 HSV_DUT
PfamiView protein in Pfam
PF00692 dUTPase, 1 hit
SUPFAMiSSF51283 SSF51283, 3 hits

Sequencei

Sequence statusi: Complete.

Q90030-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEESAGATSA QSAATSVSES PAEETILVCA SEPVTVDGGR LLVCRSPGPE
60 70 80 90 100
GFYKVPLGLK VALPTGYAML VAQRGGGRTT NGIVDAGFRG EVQAIVAPGR
110 120 130 140 150
PRAQFYCTPL RLAPGIATDV PFFEVFAPKR DEDAGYDIPC PRELVLPPGG
160 170 180 190 200
AETVTLPVHR TDGRHWAYVF GRSSLNLRGI VVFPTPWESG PCRFRIQNRG
210 220 230 240 250
AHPVTLESGQ RVAQLVLTRE PLGWITGRSP FPATPRAPMQ HRPAWLFARD
260
FVAPSSARGA RGFGSTGL
Length:268
Mass (Da):28,618
Last modified:November 1, 1996 - v1
Checksum:i79D7CFA999204776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38547 Genomic DNA Translation: AAB02855.1
X87246 Genomic DNA Translation: CAA60688.1
RefSeqiYP_068324.1, NC_006151.1

Genome annotation databases

GeneIDi2952537
KEGGivg:2952537

Similar proteinsi

Entry informationi

Entry nameiDUT_SUHVK
AccessioniPrimary (citable) accession number: Q90030
Secondary accession number(s): Q85226
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

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