Q8ZYX2 (TRPC_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	PAE0570

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	249 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_A
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_A
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 249	249	Indole-3-glycerol phosphate synthase HAMAP MF_00134_A		PRO_0000154298

Sequences

	Sequence		Length	Mass (Da)
	Q8ZYX2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9AFE800555E61B7B	FASTA	249	28,213
	10 20 30 40 50 60 MDFLTEVKRT VELRLATEPP PPARSLPLVD FIKSLGEFGI IAEYKRASPR GVIRLDLPPW 70 80 90 100 110 120 AYFAQVYQYA SAFSVLTEPF WFLGDYRFIP IAKAFKPVLM KDFVIDKRQI EAAYGYGADA 130 140 150 160 170 180 VLIIYRLVER ERAMELAEYA QRLGLTPVVE IDNVQDAKEV ATWGGRLVIG INSRDLKTLE 190 200 210 220 230 240 TNVQRAFEVA KALRGDVEFI IESGLSRPEE VERACSLYAR GVLIGTALMK NPVLVKELRQ VAERCIARR

References

[1]	"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009441 Genomic DNA. Translation: AAL62870.1.
RefSeq	NP_558688.1. NC_003364.1.
3D structure databases
ProteinModelPortal	Q8ZYX2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1465093.
GenomeReviews	Gene locus PAE0570 in contig AE009441_GR.
KEGG	pai:PAE0570.
NMPDR	fig|178306.1.peg.378.
Phylogenomic databases
HOGENOM	HBG540956.
OMA	FFPEQVK.
ProtClustDB	CLSK899510.
Enzyme and pathway databases
BioCyc	PAER178306:PAE0570-MONOMER.
Family and domain databases
HAMAP	MF_00134_A. IGPS_A. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_PYRAE

Accession

Primary (citable) accession number: Q8ZYX2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program