Q8ZYW5 (Q8ZYW5_PYRAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Ordered Locus Names:

PAE0583

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	336 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. PIRSR PIRSR001415-3 RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	202	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	255	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	123	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	125	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	133	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	240	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	212	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	224	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	282	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	321	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q8ZYW5 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 97029669F63E16DA	FASTA	336	37,168
	10 20 30 40 50 60 MRFPVTRPRR LRASKLIREA VAETSLDSSD FIYPIFVKPS GPREPISSMP GQYRWPVGEE 70 80 90 100 110 120 LVKHVEEALS LGVNKVILFG VVPDEVKDAQ GSPGYDPQGV VPKAIRLLKE AFGDKLLIFA 130 140 150 160 170 180 DVCLCEYTEH GHCGVVRERR GRWYVDNDET IKLYAKEAVA YADAGADFVA PSGMMDGQVA 190 200 210 220 230 240 EIRKALDSHG FHDVGIMAYS AKYASAFYGP FRVAAASAPK FGDRRTYQMD PRNAYEAVKE 250 260 270 280 290 300 VMLDLEEGAD IVMVKPALAY LDVIKIVKTH YPWAPLAAYN VSGEYAMVKA AASLGYIDER 310 320 330 VVTLEILTAI KRAGANLILT YHALEAARWL KEGSPF

References

[1]	"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009441 Genomic DNA. Translation: AAL62877.1.
RefSeq	NP_558695.1. NC_003364.1.
3D structure databases
HSSP	HSSP built from PDB template 1PV8 based on UniProtKB P13716.
ProteinModelPortal	Q8ZYW5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1465101.
GenomeReviews	Gene locus PAE0583 in contig AE009441_GR.
KEGG	pai:PAE0583.
NMPDR	fig|178306.1.peg.385.
Phylogenomic databases
HOGENOM	HBG285270.
OMA	ADLCFCE.
ProtClustDB	PRK09283.
Enzyme and pathway databases
BioCyc	PAER178306:PAE0583-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8ZYW5_PYRAE

Accession

Primary (citable) accession number: Q8ZYW5

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)