ID   Q8ZYE4_PYRAE            Unreviewed;       369 AA.
AC   Q8ZYE4;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 118.
DE   SubName: Full=Serine/threonine protein kinase, putative {ECO:0000313|EMBL:AAL63049.1};
GN   OrderedLocusNames=PAE0815 {ECO:0000313|EMBL:AAL63049.1};
OS   Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP
OS   104966 / NBRC 100827 / IM2).
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Pyrobaculum.
OX   NCBI_TaxID=178306 {ECO:0000313|EMBL:AAL63049.1, ECO:0000313|Proteomes:UP000002439};
RN   [1] {ECO:0000313|EMBL:AAL63049.1, ECO:0000313|Proteomes:UP000002439}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 /
RC   IM2 {ECO:0000313|Proteomes:UP000002439};
RX   PubMed=11792869; DOI=10.1073/pnas.241636498;
RA   Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I.,
RA   Miller J.H.;
RT   "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum
RT   aerophilum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. NEK Ser/Thr
CC       protein kinase family. NIMA subfamily. {ECO:0000256|ARBA:ARBA00010886}.
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DR   EMBL; AE009441; AAL63049.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8ZYE4; -.
DR   STRING; 178306.PAE0815; -.
DR   EnsemblBacteria; AAL63049; AAL63049; PAE0815.
DR   KEGG; pai:PAE0815; -.
DR   PATRIC; fig|178306.9.peg.598; -.
DR   eggNOG; arCOG03682; Archaea.
DR   HOGENOM; CLU_036686_0_0_2; -.
DR   InParanoid; Q8ZYE4; -.
DR   Proteomes; UP000002439; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR43671:SF13; LD04361P; 1.
DR   PANTHER; PTHR43671; SERINE/THREONINE-PROTEIN KINASE NEK; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Kinase {ECO:0000313|EMBL:AAL63049.1}; Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002439};
KW   Serine/threonine-protein kinase {ECO:0000313|EMBL:AAL63049.1};
KW   Transferase {ECO:0000313|EMBL:AAL63049.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        42..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        67..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          107..369
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   369 AA;  41513 MW;  708EA77F44356B9E CRC64;
     MSLYVFKPPQ LNKSFWLLIP ASAVATTPTV AVSALTGSIA ALLDAPPIVV VAVTAFNLYY
     LSSLGEFVAF LPASVLLLAY FFTHKRVLYL SERLPLGWLY SWLGGRYKVI RLLGVGGFSY
     VLLVRQKGKV YAAKILRYAD DYGVPLASDE NILRLFGYEM NRYLEIKSDY IVKAFEVYLP
     AVGYRDIKQY MKNPPYILLE YMEGGTLRDL LRARKRLPVQ QVIELFKQLA QGLYDIHKHN
     IVHLDIKPEN IMFTRDRKIA KIGDMGIAKV VTGGYVHSSY MSPAYAAPEV KKGLATFSSD
     IYSLGCVIYE ALTGINPNVF VENGYQIPPP SAYVADVPRW IDEIILKMLD LNPNARPNSA
     ELVNYLTRV
//