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Q8ZY17

- HISX_PYRAE

UniProt

Q8ZY17 - HISX_PYRAE

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei197 – 1971SubstrateUniRule annotation
Metal bindingi218 – 2181ZincUniRule annotation
Binding sitei218 – 2181SubstrateUniRule annotation
Metal bindingi221 – 2211ZincUniRule annotation
Binding sitei221 – 2211SubstrateUniRule annotation
Active sitei276 – 2761Proton acceptorUniRule annotation
Active sitei277 – 2771Proton acceptorUniRule annotation
Binding sitei277 – 2771SubstrateUniRule annotation
Metal bindingi306 – 3061ZincUniRule annotation
Binding sitei306 – 3061SubstrateUniRule annotation
Binding sitei358 – 3581SubstrateUniRule annotation
Metal bindingi363 – 3631ZincUniRule annotation
Binding sitei363 – 3631SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPAER178306:GCEO-707-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PAE0988
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Histidinol dehydrogenasePRO_0000135902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE0988.

Structurei

3D structure databases

ProteinModelPortaliQ8ZY17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
InParanoidiQ8ZY17.
KOiK00013.
OMAiNAMSILL.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZY17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRGFPREVLE SVWKIVDDVQ SGGLKAALEY SKRLDGVAPE PHLVTPRQGG
60 70 80 90 100
DPEVVSAALA AAKSLEALYS RISPPAAVDF YGGILRQILW KPVRRAALYV
110 120 130 140 150
PARYISTLVM LAVPARLAGV EEVYVVTPPR GVSEELLAVA KELGVKAVLA
160 170 180 190 200
LGGPHGLAYA VFHMGVDVVA GPGGLYVQAA KYILSQYVGI DGIEGPTELV
210 220 230 240 250
IYAEGVPPEV AVRGALAQLE HGPTSFAYLL SPDGELLKKA EELYVRERTS
260 270 280 290 300
SMGPLKVKKV GGIDEAVSFI DEIAPEHLEV WGRREVAYRV RNVGAVSVNM
310 320 330 340 350
PSPYLDYVAG ISHVLPTGGT ARWRGVITPL AFMKPIGIAE AVGELTLREA
360
ARKLAEYEGF KYHGEALR
Length:368
Mass (Da):39,541
Last modified:March 1, 2002 - v1
Checksum:i7346BE8A2B0333EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63179.1.
RefSeqiNP_558997.1. NC_003364.1.
WP_011007651.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL63179; AAL63179; PAE0988.
GeneIDi1465414.
KEGGipai:PAE0988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63179.1 .
RefSeqi NP_558997.1. NC_003364.1.
WP_011007651.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZY17.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE0988.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL63179 ; AAL63179 ; PAE0988 .
GeneIDi 1465414.
KEGGi pai:PAE0988.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
InParanoidi Q8ZY17.
KOi K00013.
OMAi NAMSILL.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PAER178306:GCEO-707-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiHISX_PYRAE
AccessioniPrimary (citable) accession number: Q8ZY17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3