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Q8ZXT6

- SYL_PYRAE

UniProt

Q8ZXT6 - SYL_PYRAE

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER178306:GCEO-789-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PAE1107
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 945945Leucine--tRNA ligasePRO_0000152138Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE1107.

Structurei

3D structure databases

ProteinModelPortaliQ8ZXT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi43 – 5311"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000216620.
InParanoidiQ8ZXT6.
KOiK01869.
OMAiIDKWLLH.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZXT6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELSSLFIK MAEKWQAKWA EARVYEPEPR PGAAKFFVTA AYPYPNGAIH
60 70 80 90 100
IGHGRTYLIA DVLARFHRHM GRVVLFPMGF HYTGTPILTI AEAIASGDAT
110 120 130 140 150
VIEEYMAIYG VPKDEIEKMG NPLYLARYFH EQSKRAMQKF GLGIDWTREF
160 170 180 190 200
TTIDPEYQRF IQWQFEKLRE RGLIVRGRHP VGWCPRHSMP VGAHDTKDDK
210 220 230 240 250
EPEIGQWTLI YFADGEGLVF PAATLRPETV LGVTNMWINP DAEYAVIEHN
260 270 280 290 300
GRKMVVSKDA AFRLSFQGDV RILREARGRE FVGRSVQNPV TGEWVPVYEA
310 320 330 340 350
KFVDPKVGTG VVMSVPAHAP YDYAALRDLN AVRLIPLIRV EGYGDYPAKE
360 370 380 390 400
VVERMGIKSQ TDPALEEATR EVYSAEYTKG VMREDVVGRV GAHLSEPARS
410 420 430 440 450
MLRAVFKMYF AGRPVREARE FISKWLVEAG IGGVMYDIMN KPVYCRCGTE
460 470 480 490 500
IVVKVLEDQW FINYGEGRWK ELARKLVEEM AIVPPEAKAH FLATIDWLDK
510 520 530 540 550
RACARTRGLG TPLPWSDGWV IESLSDSTIY MAFYTVIKRI RQFGIKPEQL
560 570 580 590 600
IKEFWDYVFL GVGTPEEVAK RTGVPPEQLK AIREEFDFWY PLDSRNSGKD
610 620 630 640 650
LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD
660 670 680 690 700
KAVDMYGPDP LRATLAITAE VEQDLDFRHA EAIRNAQQLM SIYSLAQRLA
710 720 730 740 750
QTAEDRSPNW LDKWLVSEIA LVLERAREAY EKVRVRQAAV EVLYNAKSVF
760 770 780 790 800
DQYLASVERP SKLAVEAARA WAVAMEPIAP HLAEEIWSIL GGEGLVVKAP
810 820 830 840 850
WPQLRPDPVA LLAKRYVDMV IDDVKRIPAF GEGVKRVVIY VNPNYAWVKA
860 870 880 890 900
ALSGDVKAVI NAGAPPQAAK RVVDIVKTLG DELRGLISAV GKFDEAEALA
910 920 930 940
SYKNYMEKAL GAPMEIYNAD DPSAPDLGSK KKVALPLRPG IYIEK
Length:945
Mass (Da):106,850
Last modified:March 1, 2002 - v1
Checksum:i2ECDFFE9EE85F243
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63260.1.
RefSeqiNP_559078.1. NC_003364.1.
WP_011007732.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL63260; AAL63260; PAE1107.
GeneIDi1465496.
KEGGipai:PAE1107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63260.1 .
RefSeqi NP_559078.1. NC_003364.1.
WP_011007732.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZXT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE1107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL63260 ; AAL63260 ; PAE1107 .
GeneIDi 1465496.
KEGGi pai:PAE1107.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000216620.
InParanoidi Q8ZXT6.
KOi K01869.
OMAi IDKWLLH.

Enzyme and pathway databases

BioCyci PAER178306:GCEO-789-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiSYL_PYRAE
AccessioniPrimary (citable) accession number: Q8ZXT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3