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Q8ZXT6

- SYL_PYRAE

UniProt

Q8ZXT6 - SYL_PYRAE

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPAER178306:GCEO-789-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PAE1107
    OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
    Taxonomic identifieri178306 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
    ProteomesiUP000002439: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 945945Leucine--tRNA ligasePRO_0000152138Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi178306.PAE1107.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8ZXT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi43 – 5311"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000216620.
    KOiK01869.
    OMAiIDKWLLH.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_A. Leu_tRNA_synth_A.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8ZXT6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELSSLFIK MAEKWQAKWA EARVYEPEPR PGAAKFFVTA AYPYPNGAIH    50
    IGHGRTYLIA DVLARFHRHM GRVVLFPMGF HYTGTPILTI AEAIASGDAT 100
    VIEEYMAIYG VPKDEIEKMG NPLYLARYFH EQSKRAMQKF GLGIDWTREF 150
    TTIDPEYQRF IQWQFEKLRE RGLIVRGRHP VGWCPRHSMP VGAHDTKDDK 200
    EPEIGQWTLI YFADGEGLVF PAATLRPETV LGVTNMWINP DAEYAVIEHN 250
    GRKMVVSKDA AFRLSFQGDV RILREARGRE FVGRSVQNPV TGEWVPVYEA 300
    KFVDPKVGTG VVMSVPAHAP YDYAALRDLN AVRLIPLIRV EGYGDYPAKE 350
    VVERMGIKSQ TDPALEEATR EVYSAEYTKG VMREDVVGRV GAHLSEPARS 400
    MLRAVFKMYF AGRPVREARE FISKWLVEAG IGGVMYDIMN KPVYCRCGTE 450
    IVVKVLEDQW FINYGEGRWK ELARKLVEEM AIVPPEAKAH FLATIDWLDK 500
    RACARTRGLG TPLPWSDGWV IESLSDSTIY MAFYTVIKRI RQFGIKPEQL 550
    IKEFWDYVFL GVGTPEEVAK RTGVPPEQLK AIREEFDFWY PLDSRNSGKD 600
    LIPNHLTFFI FNHVAIFPRE KWPRQIVANG WVLREGEKMS KSKRNVLPLD 650
    KAVDMYGPDP LRATLAITAE VEQDLDFRHA EAIRNAQQLM SIYSLAQRLA 700
    QTAEDRSPNW LDKWLVSEIA LVLERAREAY EKVRVRQAAV EVLYNAKSVF 750
    DQYLASVERP SKLAVEAARA WAVAMEPIAP HLAEEIWSIL GGEGLVVKAP 800
    WPQLRPDPVA LLAKRYVDMV IDDVKRIPAF GEGVKRVVIY VNPNYAWVKA 850
    ALSGDVKAVI NAGAPPQAAK RVVDIVKTLG DELRGLISAV GKFDEAEALA 900
    SYKNYMEKAL GAPMEIYNAD DPSAPDLGSK KKVALPLRPG IYIEK 945
    Length:945
    Mass (Da):106,850
    Last modified:March 1, 2002 - v1
    Checksum:i2ECDFFE9EE85F243
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009441 Genomic DNA. Translation: AAL63260.1.
    RefSeqiNP_559078.1. NC_003364.1.

    Genome annotation databases

    EnsemblBacteriaiAAL63260; AAL63260; PAE1107.
    GeneIDi1465496.
    KEGGipai:PAE1107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE009441 Genomic DNA. Translation: AAL63260.1 .
    RefSeqi NP_559078.1. NC_003364.1.

    3D structure databases

    ProteinModelPortali Q8ZXT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 178306.PAE1107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL63260 ; AAL63260 ; PAE1107 .
    GeneIDi 1465496.
    KEGGi pai:PAE1107.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000216620.
    KOi K01869.
    OMAi IDKWLLH.

    Enzyme and pathway databases

    BioCyci PAER178306:GCEO-789-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_A. Leu_tRNA_synth_A.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR020791. Leu-tRNA-lgase_arc.
    IPR004493. Leu-tRNA-synth_Ia_arc/euk.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 2 hits.
    TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
      Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
      Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

    Entry informationi

    Entry nameiSYL_PYRAE
    AccessioniPrimary (citable) accession number: Q8ZXT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3