Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei146Schiff-base intermediate with acetaldehydeBy similarity1
Active sitei188By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:deoC
Ordered Locus Names:PAE1231
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572901 – 226Deoxyribose-phosphate aldolaseAdd BLAST226

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE1231.

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi5 – 8Combined sources4
Helixi16 – 29Combined sources14
Beta strandi32 – 36Combined sources5
Helixi38 – 40Combined sources3
Helixi41 – 44Combined sources4
Helixi45 – 47Combined sources3
Beta strandi49 – 58Combined sources10
Turni59 – 61Combined sources3
Helixi66 – 76Combined sources11
Turni77 – 79Combined sources3
Beta strandi81 – 86Combined sources6
Helixi89 – 93Combined sources5
Helixi97 – 110Combined sources14
Turni111 – 113Combined sources3
Beta strandi114 – 119Combined sources6
Helixi122 – 124Combined sources3
Helixi127 – 140Combined sources14
Beta strandi143 – 146Combined sources4
Helixi154 – 159Combined sources6
Helixi168 – 181Combined sources14
Beta strandi186 – 192Combined sources7
Helixi196 – 206Combined sources11
Turni212 – 214Combined sources3
Beta strandi215 – 220Combined sources6
Helixi222 – 225Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCVX-ray2.00A/B1-226[»]
ProteinModelPortaliQ8ZXK7.
SMRiQ8ZXK7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZXK7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG04320. Archaea.
COG0274. LUCA.
HOGENOMiHOG000241645.
InParanoidiQ8ZXK7.
KOiK01619.
OMAiGGDWDYV.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZXK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHLVDYALL KPYLTVDEAV AGARKAEELG VAAYCVNPIY APVVRPLLRK
60 70 80 90 100
VKLCVVADFP FGALPTASRI ALVSRLAEVA DEIDVVAPIG LVKSRRWAEV
110 120 130 140 150
RRDLISVVGA AGGRVVKVIT EEPYLRDEER YTLYDIIAEA GAHFIKSSTG
160 170 180 190 200
FAEEAYAARQ GNPVHSTPER AAAIARYIKE KGYRLGVKMA GGIRTREQAK
210 220
AIVDAIGWGE DPARVRLGTS TPEALL
Length:226
Mass (Da):24,539
Last modified:March 1, 2002 - v1
Checksum:i3ECD181C7C3391C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL63340.1.

Genome annotation databases

EnsemblBacteriaiAAL63340; AAL63340; PAE1231.
KEGGipai:PAE1231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL63340.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VCVX-ray2.00A/B1-226[»]
ProteinModelPortaliQ8ZXK7.
SMRiQ8ZXK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi178306.PAE1231.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL63340; AAL63340; PAE1231.
KEGGipai:PAE1231.

Phylogenomic databases

eggNOGiarCOG04320. Archaea.
COG0274. LUCA.
HOGENOMiHOG000241645.
InParanoidiQ8ZXK7.
KOiK01619.
OMAiGGDWDYV.

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468.

Miscellaneous databases

EvolutionaryTraceiQ8ZXK7.

Family and domain databases

CDDicd00959. DeoC. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00114. DeoC_type1. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR028581. DeoC_typeI.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEOC_PYRAE
AccessioniPrimary (citable) accession number: Q8ZXK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.