Q8ZXK7 (DEOC_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	deoC
Ordered Locus Names:	PAE1231

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity. HAMAP MF_00114
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity HAMAP MF_00114.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 226

226

Deoxyribose-phosphate aldolase HAMAP MF_00114

PRO_0000057290

Sites

Active site

146

1

Schiff-base intermediate with acetaldehyde By similarity

Active site

188

1

By similarity

Secondary structure

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226

Helix Strand Turn

Details...

Helix

2 – 4

3

Beta strand

5 – 8

4

Helix

16 – 29

14

Beta strand

32 – 36

5

Helix

38 – 40

3

Helix

41 – 44

4

Helix

45 – 47

3

Beta strand

49 – 58

10

Turn

59 – 61

3

Helix

66 – 76

11

Turn

77 – 79

3

Beta strand

81 – 86

6

Helix

89 – 93

5

Helix

97 – 110

14

Turn

111 – 113

3

Beta strand

114 – 119

6

Helix

122 – 124

3

Helix

127 – 140

14

Beta strand

143 – 146

4

Helix

154 – 159

6

Helix

168 – 181

14

Beta strand

186 – 192

7

Helix

196 – 206

11

Turn

212 – 214

3

Beta strand

215 – 220

6

Helix

222 – 225

4

Sequences

	Sequence		Length	Mass (Da)
	Q8ZXK7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 3ECD181C7C3391C4	FASTA	226	24,539
	10 20 30 40 50 60 MIHLVDYALL KPYLTVDEAV AGARKAEELG VAAYCVNPIY APVVRPLLRK VKLCVVADFP 70 80 90 100 110 120 FGALPTASRI ALVSRLAEVA DEIDVVAPIG LVKSRRWAEV RRDLISVVGA AGGRVVKVIT 130 140 150 160 170 180 EEPYLRDEER YTLYDIIAEA GAHFIKSSTG FAEEAYAARQ GNPVHSTPER AAAIARYIKE 190 200 210 220 KGYRLGVKMA GGIRTREQAK AIVDAIGWGE DPARVRLGTS TPEALL

References

[1]	"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE009441 Genomic DNA. Translation: AAL63340.1.

RefSeq

NP_559158.1. NC_003364.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1VCV	X-ray	2.00	A/B	1-226	[»]

ProteinModelPortal

Q8ZXK7.

SMR

Q8ZXK7. Positions 1-226.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

1465578.

GenomeReviews

Gene locus PAE1231 in contig AE009441_GR.

KEGG

pai:PAE1231.

NMPDR

fig|178306.1.peg.848.

Phylogenomic databases

HOGENOM

HBG636421.

OMA

CLEAREN.

ProtClustDB

PRK00507.

Enzyme and pathway databases

BioCyc

PAER178306:PAE1231-MONOMER.

Family and domain databases

HAMAP

MF_00114. DeoC_type1.
[Tree]

InterPro

IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/AroFGH_arch.
IPR022979. Deoxyribose_phosphate_aldo_1.
[Graphical view]

Gene3D

G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.

KO

K01619.

PANTHER

PTHR10889. DeoC. 1 hit.

Pfam

PF01791. DeoC. 1 hit.
[Graphical view]

PIRSF

PIRSF001357. DeoC. 1 hit.

ProtoNet

Search...

Entry information

Entry name

DEOC_PYRAE

Accession

Primary (citable) accession number: Q8ZXK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2002
Last modified:	December 14, 2011
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program