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Q8ZWK6

- PGK_PYRAE

UniProt

Q8ZWK6 - PGK_PYRAE

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431SubstrateUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Binding sitei334 – 3341ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi358 – 3614ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER178306:GCEO-1238-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:PAE1742
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Phosphoglycerate kinasePRO_0000146065Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE1742.

Structurei

3D structure databases

ProteinModelPortaliQ8ZWK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 303Substrate bindingUniRule annotation
Regioni66 – 694Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
InParanoidiQ8ZWK6.
KOiK00927.
OMAiTEYHANT.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZWK6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLNEIIDLI PNINKCLKKG KTLIIRIDIN SPIVNGKIID DFRIRAHSYT
60 70 80 90 100
LRLASDAGAR AVVLAHQGRP GQDDFTSLEI HKPYIEKYLE RPIKFVDDII
110 120 130 140 150
GPEARRQIKE LKDGEILLLE NVRILSEEVI EKVPEAQAET LLVRKLAPLA
160 170 180 190 200
DYYVFDGFAV AHRSQPSVVG FPIVLPSCAG PVFERELRAL GAVFEKRGRG
210 220 230 240 250
VTLIAGGAKM PDTLKAVEQL LKNGFVEKVA VGGLVGFVFA LGKYGVLNSA
260 270 280 290 300
LKQEVEKGGF LPYIERARQL LAKYGAQIYT PVDFAVNQNG RLDVDIYSLA
310 320 330 340 350
QPPLDIGRST TIAFKEVIEQ SEIVIFSGPM GYIEDERFAT GTIELLKAAS
360 370 380 390 400
NRRLILGGGH TIMAAEKAGV LDKAYHVSTG GRAFIQTIGG EEMPAVKALL

TSAKKFSL
Length:408
Mass (Da):44,692
Last modified:March 1, 2002 - v1
Checksum:i4EB2A817FA2D1218
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63696.1.
RefSeqiNP_559514.1. NC_003364.1.
WP_011008167.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL63696; AAL63696; PAE1742.
GeneIDi1465946.
KEGGipai:PAE1742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL63696.1 .
RefSeqi NP_559514.1. NC_003364.1.
WP_011008167.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZWK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE1742.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL63696 ; AAL63696 ; PAE1742 .
GeneIDi 1465946.
KEGGi pai:PAE1742.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
InParanoidi Q8ZWK6.
KOi K00927.
OMAi TEYHANT.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci PAER178306:GCEO-1238-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiPGK_PYRAE
AccessioniPrimary (citable) accession number: Q8ZWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3