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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431SubstrateUniRule annotation
Binding sitei123 – 1231SubstrateUniRule annotation
Binding sitei163 – 1631SubstrateUniRule annotation
Binding sitei334 – 3341ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi358 – 3614ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPAER178306:GCEO-1238-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:PAE1742
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Phosphoglycerate kinasePRO_0000146065Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE1742.

Structurei

3D structure databases

ProteinModelPortaliQ8ZWK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni28 – 303Substrate bindingUniRule annotation
Regioni66 – 694Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
InParanoidiQ8ZWK6.
KOiK00927.
OMAiDAFGTCH.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZWK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLNEIIDLI PNINKCLKKG KTLIIRIDIN SPIVNGKIID DFRIRAHSYT
60 70 80 90 100
LRLASDAGAR AVVLAHQGRP GQDDFTSLEI HKPYIEKYLE RPIKFVDDII
110 120 130 140 150
GPEARRQIKE LKDGEILLLE NVRILSEEVI EKVPEAQAET LLVRKLAPLA
160 170 180 190 200
DYYVFDGFAV AHRSQPSVVG FPIVLPSCAG PVFERELRAL GAVFEKRGRG
210 220 230 240 250
VTLIAGGAKM PDTLKAVEQL LKNGFVEKVA VGGLVGFVFA LGKYGVLNSA
260 270 280 290 300
LKQEVEKGGF LPYIERARQL LAKYGAQIYT PVDFAVNQNG RLDVDIYSLA
310 320 330 340 350
QPPLDIGRST TIAFKEVIEQ SEIVIFSGPM GYIEDERFAT GTIELLKAAS
360 370 380 390 400
NRRLILGGGH TIMAAEKAGV LDKAYHVSTG GRAFIQTIGG EEMPAVKALL

TSAKKFSL
Length:408
Mass (Da):44,692
Last modified:February 28, 2002 - v1
Checksum:i4EB2A817FA2D1218
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL63696.1.
RefSeqiNP_559514.1. NC_003364.1.
WP_011008167.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL63696; AAL63696; PAE1742.
GeneIDi1465946.
KEGGipai:PAE1742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL63696.1.
RefSeqiNP_559514.1. NC_003364.1.
WP_011008167.1. NC_003364.1.

3D structure databases

ProteinModelPortaliQ8ZWK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi178306.PAE1742.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL63696; AAL63696; PAE1742.
GeneIDi1465946.
KEGGipai:PAE1742.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
InParanoidiQ8ZWK6.
KOiK00927.
OMAiDAFGTCH.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciPAER178306:GCEO-1238-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiPGK_PYRAE
AccessioniPrimary (citable) accession number: Q8ZWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2002
Last sequence update: February 28, 2002
Last modified: March 3, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.