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Q8ZWK6 (PGK_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:PAE1742
OrganismPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) [Reference proteome] [HAMAP]
Taxonomic identifier178306 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146065

Regions

Nucleotide binding358 – 3614ATP By similarity
Region28 – 303Substrate binding By similarity
Region66 – 694Substrate binding By similarity

Sites

Binding site431Substrate By similarity
Binding site1231Substrate By similarity
Binding site1631Substrate By similarity
Binding site3341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8ZWK6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 4EB2A817FA2D1218

FASTA40844,692
        10         20         30         40         50         60 
MLLNEIIDLI PNINKCLKKG KTLIIRIDIN SPIVNGKIID DFRIRAHSYT LRLASDAGAR 

        70         80         90        100        110        120 
AVVLAHQGRP GQDDFTSLEI HKPYIEKYLE RPIKFVDDII GPEARRQIKE LKDGEILLLE 

       130        140        150        160        170        180 
NVRILSEEVI EKVPEAQAET LLVRKLAPLA DYYVFDGFAV AHRSQPSVVG FPIVLPSCAG 

       190        200        210        220        230        240 
PVFERELRAL GAVFEKRGRG VTLIAGGAKM PDTLKAVEQL LKNGFVEKVA VGGLVGFVFA 

       250        260        270        280        290        300 
LGKYGVLNSA LKQEVEKGGF LPYIERARQL LAKYGAQIYT PVDFAVNQNG RLDVDIYSLA 

       310        320        330        340        350        360 
QPPLDIGRST TIAFKEVIEQ SEIVIFSGPM GYIEDERFAT GTIELLKAAS NRRLILGGGH 

       370        380        390        400 
TIMAAEKAGV LDKAYHVSTG GRAFIQTIGG EEMPAVKALL TSAKKFSL 

« Hide

References

[1]"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE009441 Genomic DNA. Translation: AAL63696.1.
RefSeqNP_559514.1. NC_003364.1.

3D structure databases

ProteinModelPortalQ8ZWK6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING178306.PAE1742.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL63696; AAL63696; PAE1742.
GeneID1465946.
KEGGpai:PAE1742.

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227108.
KOK00927.
OMADMIFDIG.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycPAER178306:GCEO-1238-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_PYRAE
AccessionPrimary (citable) accession number: Q8ZWK6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways