Q8ZW90 (AROC_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	PAE1912

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	368 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 368	368	Chorismate synthase HAMAP MF_00300		PRO_0000140695

Sequences

	Sequence		Length	Mass (Da)
	Q8ZW90 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 25C99718A1CDD1C4	FASTA	368	40,007
	10 20 30 40 50 60 MNTFGREFRI TTFGESHGKA VGVVIDGVPA GLPLSEEDIK RELERRMFCH IHWLNPRCEP 70 80 90 100 110 120 EEFEILSGVK NGHTQGTPIA IVIWNKRAIS SYYDELWMKP RPGHADLAYY LKYGKFYDHR 130 140 150 160 170 180 GGGRASGRTT AAIVAAGAVA KKLLSQLGVD VCGHIIELGG IEVRRSYTFE EVKSSWAKPL 190 200 210 220 230 240 PVVDDEALAA MLETLRKNAA EGDSVGGGVE IWAVGVPPGL GEPHFGKIKA ELAMAAFSIP 250 260 270 280 290 300 AVVALDWGAG RALAKMRGSE ANDPIIIKSG RPALESNKIG GVLGGITVGE PIYFRVWFKP 310 320 330 340 350 360 TPSVRKPQRT VDLAKMEPAV LEFKGRYDVS VVPKALVALE AMTAITLADH ALRAGLVRRD RPLRDPVV

References

[1]

"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009441 Genomic DNA. Translation: AAL63812.1.
RefSeq	NP_559630.1. NC_003364.1.
3D structure databases
ProteinModelPortal	Q8ZW90.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1464135.
GenomeReviews	Gene locus PAE1912 in contig AE009441_GR.
KEGG	pai:PAE1912.
NMPDR	fig|178306.1.peg.1320.
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	PAER178306:PAE1912-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_PYRAE

Accession

Primary (citable) accession number: Q8ZW90

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2002
Last modified:	December 14, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program