UniProtKB - Q8ZVM1 (PSA_PYRAE)
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Protein
Proteasome subunit alpha
Gene
psmA
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Functioni
Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation
Catalytic activityi
Cleavage of peptide bonds with very broad specificity.UniRule annotation
Enzyme regulationi
The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation
GO - Molecular functioni
- threonine-type endopeptidase activity Source: UniProtKB-KW
GO - Biological processi
- ubiquitin-dependent protein catabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase, Protease, Threonine protease |
Protein family/group databases
MEROPSi | T01.974. |
Names & Taxonomyi
Protein namesi | Recommended name: Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation)Alternative name(s): 20S proteasome alpha subunitUniRule annotation Proteasome core protein PsmAUniRule annotation |
Gene namesi | Name:psmAUniRule annotation Ordered Locus Names:PAE2215 |
Organismi | Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) |
Taxonomic identifieri | 178306 [NCBI] |
Taxonomic lineagei | Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
- proteasome core complex, alpha-subunit complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, ProteasomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000124182 | 1 – 243 | Proteasome subunit alphaAdd BLAST | 243 |
Interactioni
Subunit structurei
The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation
Protein-protein interaction databases
STRINGi | 178306.PAE2215. |
Structurei
3D structure databases
ProteinModelPortali | Q8ZVM1. |
SMRi | Q8ZVM1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase T1A family.UniRule annotation
Phylogenomic databases
eggNOGi | arCOG00971. Archaea. COG0638. LUCA. |
HOGENOMi | HOG000091085. |
InParanoidi | Q8ZVM1. |
KOi | K03432. |
OMAi | FQVEYAR. |
OrthoDBi | POG093Z086S. |
Family and domain databases
CDDi | cd03756. proteasome_alpha_archeal. 1 hit. |
Gene3Di | 3.60.20.10. 1 hit. |
HAMAPi | MF_00289_A. Proteasome_A_A. 1 hit. |
InterProi | View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b. |
Pfami | View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit. |
SMARTi | View protein in SMART SM00948. Proteasome_A_N. 1 hit. |
SUPFAMi | SSF56235. SSF56235. 1 hit. |
TIGRFAMsi | TIGR03633. arc_protsome_A. 1 hit. |
PROSITEi | View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8ZVM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFPPAMAGYD RAITIFSPEG KIYQVEYAGE AVKRGWPTVG VKCKAGVVLT
60 70 80 90 100
AEKRKISALF DSSSLEKIYL IDEHVAASPS GLLADARILI DYARDVALSH
110 120 130 140 150
RFIYDEPIDV EFLTKAVCNL KQQYTQFGGA RPFGVALLIA GVDRHGARLY
160 170 180 190 200
QTDPSGVYIG YFATAIGAES GTITEFLEKN YKFDMEMGEC IELALKALAS
210 220 230 240
AVEITDSANV EVAYATIEEK KMRKMSQDEV ASLLTKLGLL KKS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE009441 Genomic DNA. Translation: AAL64035.1. |
Genome annotation databases
EnsemblBacteriai | AAL64035; AAL64035; PAE2215. |
KEGGi | pai:PAE2215. |
PATRICi | fig|178306.9.peg.1647. |
Similar proteinsi
Entry informationi
Entry namei | PSA_PYRAE | |
Accessioni | Q8ZVM1Primary (citable) accession number: Q8ZVM1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2002 |
Last sequence update: | March 1, 2002 | |
Last modified: | March 28, 2018 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |