psmA

Functionⁱ

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.UniRule annotation

Catalytic activityⁱ

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationⁱ

The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.UniRule annotation

GO - Molecular functionⁱ

threonine-type endopeptidase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ubiquitin-dependent protein catabolic process Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, Threonine protease

Molecular function

Hydrolase, Protease, Threonine protease

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	T01.974.

MEROPSⁱ

T01.974.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Proteasome subunit alphaUniRule annotation (EC:3.4.25.1UniRule annotation) Alternative name(s): 20S proteasome alpha subunitUniRule annotation Proteasome core protein PsmAUniRule annotation
Gene namesⁱ	Name:psmAUniRule annotation Ordered Locus Names:PAE2215
Organismⁱ	Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifierⁱ	178306 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Archaea › TACK group › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum › Pyrobaculum aerophilum
Proteomesⁱ	UP000002439 Componentⁱ: Chromosome

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00289

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell
proteasome core complex, alpha-subunit complex Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm, Proteasome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000124182	1 – 243	Proteasome subunit alphaAdd BLAST		243

Interactionⁱ

Subunit structureⁱ

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.UniRule annotation

Protein-protein interaction databases

STRINGⁱ	178306.PAE2215.

STRINGⁱ

178306.PAE2215.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8ZVM1.
SMRⁱ	Q8ZVM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the peptidase T1A family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
InParanoidⁱ	Q8ZVM1.
KEGG Orthology (KO) More...KOⁱ	K03432.
OMAⁱ	FQVEYAR.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z086S.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03756. proteasome_alpha_archeal. 1 hit.
Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit.
SMARTⁱ	View protein in SMART SM00948. Proteasome_A_N. 1 hit.
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8ZVM1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFPPAMAGYD RAITIFSPEG KIYQVEYAGE AVKRGWPTVG VKCKAGVVLT 
        60         70         80         90        100
AEKRKISALF DSSSLEKIYL IDEHVAASPS GLLADARILI DYARDVALSH 
       110        120        130        140        150
RFIYDEPIDV EFLTKAVCNL KQQYTQFGGA RPFGVALLIA GVDRHGARLY 
       160        170        180        190        200
QTDPSGVYIG YFATAIGAES GTITEFLEKN YKFDMEMGEC IELALKALAS 
       210        220        230        240 
AVEITDSANV EVAYATIEEK KMRKMSQDEV ASLLTKLGLL KKS

Length:243

Mass (Da):26,626

Last modified:March 1, 2002 - v1

Checksum:ⁱ53D9907408AA61A9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE009441 Genomic DNA. Translation: AAL64035.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AE009441 Genomic DNA. Translation: AAL64035.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAL64035; AAL64035; PAE2215.
KEGGⁱ	pai:PAE2215.
PATRICⁱ	fig\|178306.9.peg.1647.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8ZVM1	A4WM59 H6Q6B8 G7VGS1	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7) Pyrobaculum ferrireducens	243	UniRef90_Q8ZVM1	Cluster: Proteasome subunit alpha	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8ZVM1	H6Q6B8 A4WM59 G7VGS1 A0A0F7FIG5 B1Y986 A0A101XHG2 A0A0K1E3G6 A0A101WV30 A0A101XG72 UPI0008534D3A	Pyrobaculum oguniense (strain DSM 13380 / JCM 10595 / TE7) Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) Pyrobaculum ferrireducens Thermofilum uzonense Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus) Thermocladium sp. ECH_B Pyrobaculum sp. WP30 Pyrobaculum sp. JCHS_4 Pyrobaculum sp. OCT_11 Vulcanisaeta thermophila	243	UniRef50_Q8ZVM1	Cluster: Proteasome subunit alpha	11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE009441 Genomic DNA. Translation: AAL64035.1.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AE009441 Genomic DNA. Translation: AAL64035.1.

3D structure databases

ProteinModelPortalⁱ	Q8ZVM1.
SMRⁱ	Q8ZVM1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	178306.PAE2215.

STRINGⁱ

178306.PAE2215.

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	T01.974.

MEROPSⁱ

T01.974.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAL64035; AAL64035; PAE2215.
KEGGⁱ	pai:PAE2215.
PATRICⁱ	fig\|178306.9.peg.1647.

Phylogenomic databases

eggNOGⁱ	arCOG00971. Archaea. COG0638. LUCA.
HOGENOMⁱ	HOG000091085.
InParanoidⁱ	Q8ZVM1.
KEGG Orthology (KO) More...KOⁱ	K03432.
OMAⁱ	FQVEYAR.
Database of Orthologous Groups More...OrthoDBⁱ	POG093Z086S.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd03756. proteasome_alpha_archeal. 1 hit.
Gene3Dⁱ	3.60.20.10. 1 hit.
HAMAPⁱ	MF_00289_A. Proteasome_A_A. 1 hit.
InterProⁱ	View protein in InterPro IPR029055. Ntn_hydrolases_N. IPR023332. Proteasome_alpha-type. IPR019982. Proteasome_asu_arc. IPR000426. Proteasome_asu_N. IPR001353. Proteasome_sua/b.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00227. Proteasome. 1 hit. PF10584. Proteasome_A_N. 1 hit.
SMARTⁱ	View protein in SMART SM00948. Proteasome_A_N. 1 hit.
SUPFAMⁱ	SSF56235. SSF56235. 1 hit.
TIGRFAMsⁱ	TIGR03633. arc_protsome_A. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00388. PROTEASOME_ALPHA_1. 1 hit. PS51475. PROTEASOME_ALPHA_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PSA_PYRAE
Accessionⁱ	Q8ZVM1Primary (citable) accession number: Q8ZVM1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2002
	Last sequence update:	March 1, 2002
	Last modified:	March 28, 2018
	This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8ZVM1 (PSA_PYRAE)

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Proteasome subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Enzyme regulationⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ