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Q8ZVB2

- MDH_PYRAE

UniProt

Q8ZVB2 - MDH_PYRAE

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADUniRule annotation
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei93 – 931NADUniRule annotation
Binding sitei118 – 1181SubstrateUniRule annotation
Binding sitei149 – 1491SubstrateUniRule annotation
Active sitei173 – 1731Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi6 – 116NADUniRule annotation
Nucleotide bindingi116 – 1183NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciPAER178306:GCEO-1707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PAE2370
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Malate dehydrogenasePRO_0000113491Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE2370.

Structurei

3D structure databases

ProteinModelPortaliQ8ZVB2.
SMRiQ8ZVB2. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
InParanoidiQ8ZVB2.
KOiK00024.
OMAiLDLMEAQ.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8ZVB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITIIGSGRV GTAAAVIMGL MKLDNKILLI DIVKGLPQGE ALDMNHMSSI
60 70 80 90 100
LGLDVEYVGS NEYKDIEGSD LIIVTAGLPR KPGMTREQLL EANAKIVAEI
110 120 130 140 150
GREIKKYAPD SIVILTTNPL DAMTYVMWKA TGFPRERVIG FSGVLDAGRL
160 170 180 190 200
AFYAAKKLGI SPASILPIVL GQHGESMFPV PSKSYVHGVP LSKLLTEEQL
210 220 230 240 250
KEVVEETVKA GARITELRGF SSNWGPGAGL AIMAEAVKRD AKRALIASVV
260 270 280 290 300
LQGEYGVRDV PVEVPIILGR SGVVKVLEVE LTEEERQKFM QSVEAVKKLV

ASVPPSYLQ
Length:309
Mass (Da):33,319
Last modified:March 1, 2002 - v1
Checksum:i55DB470B06779583
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL64144.1.
RefSeqiNP_559962.1. NC_003364.1.
WP_011008612.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL64144; AAL64144; PAE2370.
GeneIDi1464480.
KEGGipai:PAE2370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL64144.1 .
RefSeqi NP_559962.1. NC_003364.1.
WP_011008612.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZVB2.
SMRi Q8ZVB2. Positions 1-307.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE2370.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL64144 ; AAL64144 ; PAE2370 .
GeneIDi 1464480.
KEGGi pai:PAE2370.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
InParanoidi Q8ZVB2.
KOi K00024.
OMAi LDLMEAQ.

Enzyme and pathway databases

BioCyci PAER178306:GCEO-1707-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiMDH_PYRAE
AccessioniPrimary (citable) accession number: Q8ZVB2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3