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Protein
Submitted name:

Pyruvate dehydrogenase E2 (Dihydrolipoamide acetyltransferase)

Gene

PAE2648

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

BioCyciPAER178306:GCEO-1908-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate dehydrogenase E2 (Dihydrolipoamide acetyltransferase)Imported
Gene namesi
Ordered Locus Names:PAE2648Imported
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)Imported
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE2648.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W4INMR-A93-152[»]
1W4JNMR-A93-141[»]
1W4KNMR-A93-141[»]
ProteinModelPortaliQ8ZUR6.
SMRiQ8ZUR6. Positions 93-152.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8ZUR6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 7575Lipoyl-bindingInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiarCOG01706. Archaea.
COG0508. LUCA.
HOGENOMiHOG000281564.
InParanoidiQ8ZUR6.
KOiK00627.
OMAiKHYYNIG.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8ZUR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFKFPDLGE GLVEGEVIKW HVKEGDFVKE GDPLVDVMTE KATVTLPAPT
60 70 80 90 100
TGRVVKILVR EGEVVKVGQT LCVIEPAEGP AAGPQTEAPA RPREVAAMPA
110 120 130 140 150
ARRLAKELGI DLSKVKGTGP GGVITVEDVK RYAEETAKAT APAPAPKAVE
160 170 180 190 200
KAEEAEVVPV RGIRRAVAEK MSKAKRLIPH AYHLEEVDFT ELIKLRERVK
210 220 230 240 250
AEAEKRGIRL TLLPFIAKAV AMALREYPML NSEYDEEKNA IVVKKEVNLG
260 270 280 290 300
IGVDTEQGLV VVVVKNADKK GLLEMAKEIN ELAQKAREGK LELQDVRGST
310 320 330 340 350
FTISNIGAVG GLGGLSILNY PEAGILAVGQ ARKKPWAVGD RIEIRDIALL
360 370 380
AVSFDHRVVD GAYVARFMNR VKELLENPWL LLL
Length:383
Mass (Da):41,689
Last modified:March 1, 2002 - v1
Checksum:i82D446F290120193
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL64340.1.

Genome annotation databases

EnsemblBacteriaiAAL64340; AAL64340; PAE2648.
KEGGipai:PAE2648.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE009441 Genomic DNA. Translation: AAL64340.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1W4INMR-A93-152[»]
1W4JNMR-A93-141[»]
1W4KNMR-A93-141[»]
ProteinModelPortaliQ8ZUR6.
SMRiQ8ZUR6. Positions 93-152.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi178306.PAE2648.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL64340; AAL64340; PAE2648.
KEGGipai:PAE2648.

Phylogenomic databases

eggNOGiarCOG01706. Archaea.
COG0508. LUCA.
HOGENOMiHOG000281564.
InParanoidiQ8ZUR6.
KOiK00627.
OMAiKHYYNIG.

Enzyme and pathway databases

BioCyciPAER178306:GCEO-1908-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8ZUR6.

Family and domain databases

Gene3Di3.30.559.10. 1 hit.
4.10.320.10. 1 hit.
InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR023213. CAT-like_dom.
IPR004167. E3-bd.
IPR011053. Single_hybrid_motif.
[Graphical view]
PfamiPF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
[Graphical view]
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
PROSITEiPS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827Imported.
  2. "Ultra-fast barrier-limited folding in the peripheral subunit-binding domain family."
    Ferguson N., Sharpe T.D., Schartau P.J., Sato S., Allen M.D., Johnson C.M., Rutherford T.J., Fersht A.R.
    J. Mol. Biol. 353:427-446(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 93-152.

Entry informationi

Entry nameiQ8ZUR6_PYRAE
AccessioniPrimary (citable) accession number: Q8ZUR6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.