Q8ZU95 (ARLY_PYRAE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	PAE2887

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum

Protein attributes

Sequence length	429 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 429	429	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137867

Sequences

	Sequence		Length	Mass (Da)
	Q8ZU95 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 294D51EFB2BCA578	FASTA	429	47,472
	10 20 30 40 50 60 MSFYRSWIGG TGDLVKKYTS SIKDDVELAE EVVRVMKGHV AHLVEIGSIP KEAGERIIKA 70 80 90 100 110 120 LEEVDASELL KEEFEDVHEA LEKWLIDKLG EEIGGWVGLG RSRNDHVAAA IRLAALRKTE 130 140 150 160 170 180 RLKEEACRLR CALAKRALEY ADCPMPSFTH FQPAQVITFG HYLLAIDELL AEFLHILRGV 190 200 210 220 230 240 EDLLNRSPLG AGPAGGVRTP LDRRRLAELV GFKEVVENAL YASGSRFFAL ALASAVVSFL 250 260 270 280 290 300 AELSRAVDDF IRWNSPVVGY VNSPDSHVST SSIMPHKRNL VTLEVLRARI AEALGHFAAM 310 320 330 340 350 360 SALVMKVGMG YSLDLQEATR HLWAVLNIAT EGMAVFRDFI ENMAFNCEKS RKDAEAYFTT 370 380 390 400 410 420 SSDTAEDEAL KGVPFRKAYF QLASAIKAGT ARLLTINEAL KRPVYGSANT EEVKRAASRR LALCRPKPL

References

[1]

"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed: 11792869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009441 Genomic DNA. Translation: AAL64513.1.
RefSeq	NP_560331.1. NC_003364.1.
3D structure databases
ProteinModelPortal	Q8ZU95.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1463675.
GenomeReviews	Gene locus PAE2887 in contig AE009441_GR.
KEGG	pai:PAE2887.
NMPDR	fig|178306.1.peg.2021.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	PAER178306:PAE2887-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_PYRAE

Accession

Primary (citable) accession number: Q8ZU95

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program