Q8ZU12 (Q8ZU12_PYRAE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA topoisomerase (TopA) EMBL AAL64596.1

Gene names

Ordered Locus Names:

PAE2993

Organism

Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) [Reference proteome] [HAMAP] EMBL AAL64596.1

Taxonomic identifier

178306 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Pyrobaculum › Pyrobaculum aerophilum

Protein attributes

Sequence length	602 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the type IA topoisomerase family. RuleBase RU004206

Ontologies

Keywords
Molecular function	Isomerase EMBL AAL64596.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA topological change Inferred from electronic annotation. Source: InterPro
Cellular_component	chromosome Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA topoisomerase type I activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8ZU12 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9BF943C0805536CF	FASTA	602	67,653
	10 20 30 40 50 60 MKLIVAEKRS VAQSIAKFLG RSYKSQKLYG VSVYRFNYGG GEAVAIGLSG HIMDFDFAAR 70 80 90 100 110 120 QNVWTWLPPE ELFNATPILV LRGETLKYVK ALKSLATKAD EVYLALDADV EGEAIAYETA 130 140 150 160 170 180 LVVKMVNPRA RLYRVRFNAV TYKEIVSAFQ KPTYIDLKKV EKVFTRMQVD LTLGAVFTRF 190 200 210 220 230 240 LTLTVRNSLN KGQFLSYGPC QTPVLGIVVT RELQRRNFKP EKYYVIKAVV EIGSSKVEMS 250 260 270 280 290 300 ADAKFKTKGE AEAIAATIKR GVVKIAVYKP HYVEPPEPLE TVELERRASR WLGINSKKTL 310 320 330 340 350 360 DIAEELYRAG YISYPRTETT IYPPTLDLKE VLEELTAGEH GPYALELLRK GFKPTRGDSD 370 380 390 400 410 420 DGAHPPIYPT KGATRAEIFK VFGKAGGHAW AVYDLVVRHF LATLSPPALV EKQKIVVSFG 430 440 450 460 470 480 KIELSAEGQR TIDEGYWRIY PWERQPEKPL PRVAPGEPAR AVEIRVVERE TEPPPQMTES 490 500 510 520 530 540 ELLALMKKYG IGTDATMQDH IYTNIKRGYV KLVKGKCIPT ALGISLATSL FQYAPELIEP 550 560 570 580 590 600 TVRAKIEKSL NSIVKDGVSP AKLIAEIKLE FSKYYQNLKA KREEIKKALE TALYSIQQQS RG

References

[1]

"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum." Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H. Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE009441 Genomic DNA. Translation: AAL64596.1.
RefSeq	NP_560414.1. NC_003364.1.
3D structure databases
HSSP	HSSP built from PDB template 1ECL based on UniProtKB P06612.
ProteinModelPortal	Q8ZU12.
ModBase	Search...
Protein-protein interaction databases
STRING	178306.PAE2993.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL64596; AAL64596; PAE2993.
GeneID	1463761.
KEGG	pai:PAE2993.
Phylogenomic databases
eggNOG	COG0550.
HOGENOM	HOG000184377.
KO	K03168.
OMA	KGKCIPT.
ProtClustDB	CLSK899822.
Family and domain databases
Gene3D	1.10.290.10. 1 hit. 1.10.460.10. 2 hits.
InterPro	IPR000380. Topo_IA. IPR003601. Topo_IA_2. IPR013497. Topo_IA_cen. IPR013824. Topo_IA_cen_sub1. IPR013826. Topo_IA_cen_sub3. IPR023405. Topo_IA_core_domain. IPR003602. Topo_IA_DNA-bd. IPR006171. Toprim_domain. [Graphical view]
PANTHER	PTHR11390. PTHR11390. 1 hit.
Pfam	PF01131. Topoisom_bac. 1 hit. PF01751. Toprim. 1 hit. [Graphical view]
PRINTS	PR00417. PRTPISMRASEI.
SMART	SM00437. TOP1Ac. 1 hit. SM00436. TOP1Bc. 1 hit. SM00493. TOPRIM. 1 hit. [Graphical view]
SUPFAM	SSF56712. Topo_IA_core. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8ZU12_PYRAE

Accession

Primary (citable) accession number: Q8ZU12

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)