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Q8ZTZ0

- GLMS_PYRAE

UniProt

Q8ZTZ0 - GLMS_PYRAE

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, PAE3025
Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei597 – 5971For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPAER178306:GCEO-2194-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:PAE3025
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135429Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE3025.

Structurei

3D structure databases

ProteinModelPortaliQ8ZTZ0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221Glutamine amidotransferase type-2
Add
BLAST
Domaini284 – 422139SIS 1
Add
BLAST
Domaini452 – 592141SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiHAESYPA.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZTZ0-1 [UniParc]FASTAAdd to Basket

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MCGIFGIIFA ERPRRPLGEI LRRGLERLEY RGYDSAGVAV VDRGLVVKKD    50
AGKVAEVAQR YGFDSLQGVV GLAHTRWATH GKPDQVNAHP HVDCRGVIAV 100
VHNGIIEKYA ELKEELMKRG HVFRSETDTE VIAHLVEEYK KQGLDTFSAF 150
KKALSRVRGA YAIALIDAEN PRAIYFARNL SPLIIGVGEG FNIVASDIPT 200
VLDHTKRVIA VRDGEYGYIT AGEVYIEADG VPQDVAARIE EIPWSAEMAT 250
KGGYPHFMLK EIYEQPESLA STAAGLEPAQ IETVANALLA ARNVYIVGAG 300
TSYHAGLTLA FILPRLRITP IPVISSEYAI YEDLYDKDDL AIAISQSGET 350
IDTIKAVKAM RERGVKVVAV TNVVGSTLSR ESDVVLYTRA GPEIGVAATK 400
TFTTQVLTLA AVYLTALRAL GHDVAEHQRE LKAVPDLARK TIEKTAGTAK 450
ELAKRLRQRH SAYYLGRGAA LPVAMEGALK LKEVAYLHAE AYPAGESKHG 500
PIALVEEGFP VIFVFSDPNT GEKTLSNVAE MKARGALTIG TVPARSDYAK 550
KLDVAIEVPQ TSELFAPILH VIPLQMLAYF TAVERGYDPD KPRNLAKTVT 600
VE 602
Length:602
Mass (Da):65,564
Last modified:January 23, 2007 - v3
Checksum:i6863454F9EAC1000
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL64619.1.
RefSeqiNP_560437.1. NC_003364.1.
WP_011009087.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL64619; AAL64619; PAE3025.
GeneIDi1463787.
KEGGipai:PAE3025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL64619.1 .
RefSeqi NP_560437.1. NC_003364.1.
WP_011009087.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZTZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE3025.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL64619 ; AAL64619 ; PAE3025 .
GeneIDi 1463787.
KEGGi pai:PAE3025.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi HAESYPA.

Enzyme and pathway databases

BioCyci PAER178306:GCEO-2194-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiGLMS_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 75 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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