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Q8ZTZ0

- GLMS_PYRAE

UniProt

Q8ZTZ0 - GLMS_PYRAE

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei597 – 5971For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciPAER178306:GCEO-2194-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:PAE3025
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
ProteomesiUP000002439: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135429Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi178306.PAE3025.

Structurei

3D structure databases

ProteinModelPortaliQ8ZTZ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini284 – 422139SIS 1UniRule annotationAdd
BLAST
Domaini452 – 592141SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
InParanoidiQ8ZTZ0.
KOiK00820.
OMAiHAESYPA.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8ZTZ0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MCGIFGIIFA ERPRRPLGEI LRRGLERLEY RGYDSAGVAV VDRGLVVKKD
60 70 80 90 100
AGKVAEVAQR YGFDSLQGVV GLAHTRWATH GKPDQVNAHP HVDCRGVIAV
110 120 130 140 150
VHNGIIEKYA ELKEELMKRG HVFRSETDTE VIAHLVEEYK KQGLDTFSAF
160 170 180 190 200
KKALSRVRGA YAIALIDAEN PRAIYFARNL SPLIIGVGEG FNIVASDIPT
210 220 230 240 250
VLDHTKRVIA VRDGEYGYIT AGEVYIEADG VPQDVAARIE EIPWSAEMAT
260 270 280 290 300
KGGYPHFMLK EIYEQPESLA STAAGLEPAQ IETVANALLA ARNVYIVGAG
310 320 330 340 350
TSYHAGLTLA FILPRLRITP IPVISSEYAI YEDLYDKDDL AIAISQSGET
360 370 380 390 400
IDTIKAVKAM RERGVKVVAV TNVVGSTLSR ESDVVLYTRA GPEIGVAATK
410 420 430 440 450
TFTTQVLTLA AVYLTALRAL GHDVAEHQRE LKAVPDLARK TIEKTAGTAK
460 470 480 490 500
ELAKRLRQRH SAYYLGRGAA LPVAMEGALK LKEVAYLHAE AYPAGESKHG
510 520 530 540 550
PIALVEEGFP VIFVFSDPNT GEKTLSNVAE MKARGALTIG TVPARSDYAK
560 570 580 590 600
KLDVAIEVPQ TSELFAPILH VIPLQMLAYF TAVERGYDPD KPRNLAKTVT

VE
Length:602
Mass (Da):65,564
Last modified:January 23, 2007 - v3
Checksum:i6863454F9EAC1000
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL64619.1.
RefSeqiNP_560437.1. NC_003364.1.

Genome annotation databases

EnsemblBacteriaiAAL64619; AAL64619; PAE3025.
GeneIDi1463787.
KEGGipai:PAE3025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE009441 Genomic DNA. Translation: AAL64619.1 .
RefSeqi NP_560437.1. NC_003364.1.

3D structure databases

ProteinModelPortali Q8ZTZ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 178306.PAE3025.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL64619 ; AAL64619 ; PAE3025 .
GeneIDi 1463787.
KEGGi pai:PAE3025.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
InParanoidi Q8ZTZ0.
KOi K00820.
OMAi HAESYPA.

Enzyme and pathway databases

BioCyci PAER178306:GCEO-2194-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
    Fitz-Gibbon S.T., Ladner H., Kim U.-J., Stetter K.O., Simon M.I., Miller J.H.
    Proc. Natl. Acad. Sci. U.S.A. 99:984-989(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827.

Entry informationi

Entry nameiGLMS_PYRAE
AccessioniPrimary (citable) accession number: Q8ZTZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3